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HEMOLYTIC ANEMIA IN INFANCY

HEMOLYTIC ANEMIA IN INFANCY Recently a case of recurrent acute hemolytic anemia in a 4½ month old infant was observed in the pediatric service of Vanderbilt University Hospital.1 During a hemolytic crisis it was possible to demonstrate hemolytic activity of the patient's serum against his own red blood cells as well as against those of another patient of the same blood group. After splenectomy the patient made a complete recovery. This was associated with disappearance of the hemolytic activity of his blood serum. During infancy recurrent hemolytic anemia, accompanied by slight icterus and enlargement of the spleen, is uncommon. In pediatric literature this condition has been classified as a form of the disease which is variously referred to ascongenital hemolytic icterus, congenital hemolytic anemia and familial spherocytosis. However, the usual criteria by which a diagnosis of congenital hemolytic anemia is established may not all be present in the infant. In addition, the clinical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1944 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1944.02020110028006
Publisher site
See Article on Publisher Site

Abstract

Recently a case of recurrent acute hemolytic anemia in a 4½ month old infant was observed in the pediatric service of Vanderbilt University Hospital.1 During a hemolytic crisis it was possible to demonstrate hemolytic activity of the patient's serum against his own red blood cells as well as against those of another patient of the same blood group. After splenectomy the patient made a complete recovery. This was associated with disappearance of the hemolytic activity of his blood serum. During infancy recurrent hemolytic anemia, accompanied by slight icterus and enlargement of the spleen, is uncommon. In pediatric literature this condition has been classified as a form of the disease which is variously referred to ascongenital hemolytic icterus, congenital hemolytic anemia and familial spherocytosis. However, the usual criteria by which a diagnosis of congenital hemolytic anemia is established may not all be present in the infant. In addition, the clinical

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Nov 1, 1944

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