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HEMOCIDAL PROPERTIES OF THE BLOOD SERUM: WITH SPECIAL REFERENCE TO PERNICIOUS ANEMIA

HEMOCIDAL PROPERTIES OF THE BLOOD SERUM: WITH SPECIAL REFERENCE TO PERNICIOUS ANEMIA Abstract Notwithstanding the fact that increased destruction of blood in pernicious anemia was demonstrated over thirty years ago by Hunter,1 it would appear from a careful search of the literature that a direct destructive action of the blood serum on the red corpuscles in this disease has not been demonstrated. The bulk of the research on the mechanism of erythrocyte destruction in pernicious anemia appears to have been directed toward the demonstration of a localization of the process in certain organs, especially in the bone marrow, spleen, hemolymph nodes and liver. The investigations have been carried out principally along three different lines of pursuit: (1) histologic studies of the phagocytic activity of the cells of the different organs, (2) the quantitative determination of the iron content of these organs, and (3) the isolation of hemolytic substances from these organs. Hunter found excessive deposits of pigment in the cells of the livers References 1. Hunter, William: Pernicious Anemia , Charles Griffin & Company, 1901, p. 77 2. Severest Anemias , London, 1909, p. 110 3. Brit. M. J. 2:81, 1890Crossref 4. Lancet 1: 287, 1890 5. 1:283, 1903. 6. Dickson: The Bone Marrow , New York, Longmans, Green and Company, 1908, p. 73. 7. Schneider, J. P.: The Splenic Pathology of Pernicious Anemia and Allied Conditions , Arch. Int. Med. 17:32 ( (Jan.) ) 1916Crossref 8. Journal-Lancet 37:105, 1917. 9. Warthin, A. S.: Am. J. M. Sc. 124:674, 1902Crossref 10. J. M. Research 7:435, 1902. 11. Queincke: Deutsches Arch. f. klin. Med. 27:193, 1880. 12. Muir and Dunn, Shaw: J. Path. & Bact. 20:41, 1915 13. 21:417, 1917. 14. Ryffel, J. H.: J. Path. & Bact. 14:411, 1909. 15. Robertson, O. H.: A Study of Hemolytic Activity of the Spleen in Pernicious Anemia , Arch. Int. Med. 16:652 ( (Oct.) ) 1915 16. Urobilin in the Stool— Urobilin in the Stool in Pernicious Anemia as Influenced by Splenectomy, Transfusion and Salvarsan , Robertson Arch. Int. Med. 16:429 ( (Sept.) ) 1915 17. An Index to Blood Destruction, 15:1072 (Dec.) 1915 18. Robertson and Rous: J. Exper. Med. 25:665 and 651, 1917. 19. Nolf, P.: Compt. rend. Soc. de biol. 72:121, 1912. 20. Banti: Semaine méd. 32:265, 1912 21. 32:313, 1913. 22. Pearce, Krumbhaar and Frazier: Spleen and Anemia , Philadelphia, Lippencott & Company, 1918. 23. Wells: Chemical Pathology , Philadelphia, W. B. Saunders Company. 24. Bottazzi: Lo Sperimentale 68:433, 1894. 25. Butler: Quart. J. Med. 6:145, 1912. 26. Bigland: Quart. J. Med. 7:370, 1913. 27. Rous, P.: J. Exper. Med. 11:763, 1909. 28. Pepper, O. H. P., and Peet, N. M.: The Resistance of Reticulated Erythrocytes , Arch. Int. Med. 12:81 ( (July) ) 1913. 29. Minot and Lee: Boston M. & S. J. 177:761, 1917. 30. Minot, G. R.: Oxford Medicine , vol. 2, p. 589. 31. Lee, R. I., and Minot, G. R.: Cleveland M. J. 16:65, 1917. 32. Minot, G. R.: Boston M. & J. 174:667, 1916. 33. Lee, R. I.; Minot, G. R., and Vincent, B.: Splenectomy in Pernicious Anemia; Studies in Bone Marrow Stimulation , J. A. M. A. 67:719 ( (Sept. 2) ) 1916. 34. Minot, G. R.: Bull. Johns Hopkins Hosp. 25:338, 1914. 35. Eppinger: Berl. klin. Wchnschr. 50:1509, 1572 and 2409, 1913. 36. Wilber and Aldis: Urobilin: Its Clinical Significance , Arch. Int. Med. 13:235 ( (Feb.) ) 1914. 37. Pearce, R. M., and others: J. Exper. Med. 16:363 and 780, 1912. 38. Hirschfield: Ztschr. f. klin. Med. 87:165, 1919. 39. Joannovics, G., and Pick, E. P.: Ztschr. f. exper. Path. u. Therap. 7:185, 1910. 40. King, J. H.: Studies in the Pathology of the Spleen , Arch. Int. Med. 14: 145 ( (Aug.) ) 1914. 41. McPhedran: J. Exper. Med. 27:527, 1913. 42. Cederberg: Berl. klin. Wchnschr. 51:585, 1914. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

HEMOCIDAL PROPERTIES OF THE BLOOD SERUM: WITH SPECIAL REFERENCE TO PERNICIOUS ANEMIA

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Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1928.00130160032003
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Abstract

Abstract Notwithstanding the fact that increased destruction of blood in pernicious anemia was demonstrated over thirty years ago by Hunter,1 it would appear from a careful search of the literature that a direct destructive action of the blood serum on the red corpuscles in this disease has not been demonstrated. The bulk of the research on the mechanism of erythrocyte destruction in pernicious anemia appears to have been directed toward the demonstration of a localization of the process in certain organs, especially in the bone marrow, spleen, hemolymph nodes and liver. The investigations have been carried out principally along three different lines of pursuit: (1) histologic studies of the phagocytic activity of the cells of the different organs, (2) the quantitative determination of the iron content of these organs, and (3) the isolation of hemolytic substances from these organs. Hunter found excessive deposits of pigment in the cells of the livers References 1. Hunter, William: Pernicious Anemia , Charles Griffin & Company, 1901, p. 77 2. Severest Anemias , London, 1909, p. 110 3. Brit. M. J. 2:81, 1890Crossref 4. Lancet 1: 287, 1890 5. 1:283, 1903. 6. Dickson: The Bone Marrow , New York, Longmans, Green and Company, 1908, p. 73. 7. Schneider, J. P.: The Splenic Pathology of Pernicious Anemia and Allied Conditions , Arch. Int. Med. 17:32 ( (Jan.) ) 1916Crossref 8. Journal-Lancet 37:105, 1917. 9. Warthin, A. S.: Am. J. M. Sc. 124:674, 1902Crossref 10. J. M. Research 7:435, 1902. 11. Queincke: Deutsches Arch. f. klin. Med. 27:193, 1880. 12. Muir and Dunn, Shaw: J. Path. & Bact. 20:41, 1915 13. 21:417, 1917. 14. Ryffel, J. H.: J. Path. & Bact. 14:411, 1909. 15. Robertson, O. H.: A Study of Hemolytic Activity of the Spleen in Pernicious Anemia , Arch. Int. Med. 16:652 ( (Oct.) ) 1915 16. Urobilin in the Stool— Urobilin in the Stool in Pernicious Anemia as Influenced by Splenectomy, Transfusion and Salvarsan , Robertson Arch. Int. Med. 16:429 ( (Sept.) ) 1915 17. An Index to Blood Destruction, 15:1072 (Dec.) 1915 18. Robertson and Rous: J. Exper. Med. 25:665 and 651, 1917. 19. Nolf, P.: Compt. rend. Soc. de biol. 72:121, 1912. 20. Banti: Semaine méd. 32:265, 1912 21. 32:313, 1913. 22. Pearce, Krumbhaar and Frazier: Spleen and Anemia , Philadelphia, Lippencott & Company, 1918. 23. Wells: Chemical Pathology , Philadelphia, W. B. Saunders Company. 24. Bottazzi: Lo Sperimentale 68:433, 1894. 25. Butler: Quart. J. Med. 6:145, 1912. 26. Bigland: Quart. J. Med. 7:370, 1913. 27. Rous, P.: J. Exper. Med. 11:763, 1909. 28. Pepper, O. H. P., and Peet, N. M.: The Resistance of Reticulated Erythrocytes , Arch. Int. Med. 12:81 ( (July) ) 1913. 29. Minot and Lee: Boston M. & S. J. 177:761, 1917. 30. Minot, G. R.: Oxford Medicine , vol. 2, p. 589. 31. Lee, R. I., and Minot, G. R.: Cleveland M. J. 16:65, 1917. 32. Minot, G. R.: Boston M. & J. 174:667, 1916. 33. Lee, R. I.; Minot, G. R., and Vincent, B.: Splenectomy in Pernicious Anemia; Studies in Bone Marrow Stimulation , J. A. M. A. 67:719 ( (Sept. 2) ) 1916. 34. Minot, G. R.: Bull. Johns Hopkins Hosp. 25:338, 1914. 35. Eppinger: Berl. klin. Wchnschr. 50:1509, 1572 and 2409, 1913. 36. Wilber and Aldis: Urobilin: Its Clinical Significance , Arch. Int. Med. 13:235 ( (Feb.) ) 1914. 37. Pearce, R. M., and others: J. Exper. Med. 16:363 and 780, 1912. 38. Hirschfield: Ztschr. f. klin. Med. 87:165, 1919. 39. Joannovics, G., and Pick, E. P.: Ztschr. f. exper. Path. u. Therap. 7:185, 1910. 40. King, J. H.: Studies in the Pathology of the Spleen , Arch. Int. Med. 14: 145 ( (Aug.) ) 1914. 41. McPhedran: J. Exper. Med. 27:527, 1913. 42. Cederberg: Berl. klin. Wchnschr. 51:585, 1914.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 1, 1928

References