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Hemochromatosis and the Skin

Hemochromatosis and the Skin Abstract Hemochromatosis, a remarkable disease from several standpoints, is associated with pigmentary changes of the skin in a high percentage of patients who have the disorder. For many years it was thought that this discoloration was caused by two pigments, hemosiderin and melanin. More References 1. Von Recklinghausen, quoted by Heilmeyer, L.: Pathogenesis of Hemochromatosis , Medicine 26:209-215 ( (March) ) 1967. 2. Sheldon, J.H.: Hemochromatosis , London: Oxford University Press, 1935. 3. Idiopathic Hemochromatosis: I. Etiology and Pathogenesis , editorial, Canad Med Assoc 96:1582-1583 ( (June 17) ) 1967. 4. MacDonald, R.A.: Primary Hemochromatosis: Inherited or Acquired? Progr Hema 5:324-353, 1966. 5. Crosby, W.H., and MacDonald, R.A.: Controversy in Internal Medicine , Philadelphia: W. B. Saunders Company, 1966, pp 261-286. 6. Bothwell, T.H., and Finch, C.A.: Iron Metabolism , Boston: Little, Brown & Company, 1962. 7. Heilmeyer, L.: Pathogenesis of Hemochromatosis , Medicine 26:209-215 ( (March) ) 1967.Crossref 8. Finch, S.C., and Finch, C.A.: Idiopathic Hemochromatosis, an Iron Storage Disease , Medicine 34:381-430 ( (Dec) ) 1955.Crossref 9. Danehower, C.: Hemochromatosis , Bull Assoc Military Dermatologists 16:12-16 ( (Aug) ) 1967. 10. Richter, G.W.: The Nature of Hemosiderin Granules in Idiopathic Hemochromatosis: Electron Microscopy, Chemical and Serologic Studies , Amer J Path 35:690-691 ( (May) -June) 1959. 11. Richter, G.W.: The Nature of Storage Iron in Idiopathic Hemochromatosis and in Hemosiderosis: Electron Optical, Chemical and Serologic Studies on Isolated Hemosiderin Granules , J Exp Med 112:551-567 ( (Oct) ) 1960.Crossref 12. Blanc, B., and Vannotti, A.: Transferrin Behaviour in Haemochromatosis , Nature 212:480-481 ( (Oct 29) ) 1966.Crossref 13. Mazur, A., and Sackler, M.: Haemochromatosis and Hepatic Xanthine Oxidase , Lancet 1:254-255 ( (Feb 4) ) 1967.Crossref 14. Davis, P.S.; Luke, C.G.; and Deller, D.J.: Reduction of Gastric Iron-Binding Protein in Haemochromatosis , Lancet 2:1431-1433 ( (Dec 31) ) 1966.Crossref 15. Smith, P.M.; Studley, F.; and Williams, R.: Assessment of Body-Iron Stores in Cirrhosis and Haemochromatosis With the Differential Ferrioxamine Test , Lancet 1:133-136 ( (Jan 21) ) 1967.Crossref 16. Lillie, R.D.: Histopathologic Technic and Practical Histochemistry , New York: The Blakiston Company, Inc., 1954. 17. Spellberg, M.A.: Diseases of the Liver , New York: Grune & Stratton, Inc., 1954. 18. Gillman, J., and Gillman, T.: The Pathogenesis of Cytosiderosis (Hemochromatosis) as Evidenced in Malnourished Africans , Gastroenterology 8:19-23 ( (Jan) ) 1947. 19. Perdrup, A., and Poulsen, H.: Hemochromatosis and Vitiligo , Arch Derm 90:34-37 ( (July) ) 1964.Crossref 20. Hellier, F.F.: The Nature and Causation of the Skin Pigmentation in Haemochromatosis , Brit J Derm Syph 47:1-12 ( (Jan) ) 1935.Crossref 21. Lever, W.F.: Histopathology of the Skin , Philadelphia: J. B. Lippincott Company, 1967. 22. Robert, Von P., and Zürcher, H.: Pigmentstudien , Dermatologica 100:217-241, 1950.Crossref 23. Althausen, T.L., et al: Hemochromatosis , Arch Intern Med 88:553-570 ( (Nov) ) 1951.Crossref 24. Lerner, A.B., and Case, J.D.: Pigment Cell Regulatory Factors , J Invest Derm 32:211-221 ( (Feb) ) 1959.Crossref 25. Weintraub, L., et al: Iron Excretion by the Skin: Selective Localization of Iron59 in Epithelial Cells , Amer J Path 46:121-126 ( (Jan) ) 1965. 26. Magnuson, H.J., and Raulston, B.O.: The Iron Content of the Skin in Hemochromatosis , Ann Intern Med 16:687-693 ( (April) ) 1942.Crossref 27. Szabo, G., quoted in an editorial on Malignant Melanoma , Lancet 1:76-77 ( (Jan 13) ) 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1969.01610250007001
Publisher site
See Article on Publisher Site

Abstract

Abstract Hemochromatosis, a remarkable disease from several standpoints, is associated with pigmentary changes of the skin in a high percentage of patients who have the disorder. For many years it was thought that this discoloration was caused by two pigments, hemosiderin and melanin. More References 1. Von Recklinghausen, quoted by Heilmeyer, L.: Pathogenesis of Hemochromatosis , Medicine 26:209-215 ( (March) ) 1967. 2. Sheldon, J.H.: Hemochromatosis , London: Oxford University Press, 1935. 3. Idiopathic Hemochromatosis: I. Etiology and Pathogenesis , editorial, Canad Med Assoc 96:1582-1583 ( (June 17) ) 1967. 4. MacDonald, R.A.: Primary Hemochromatosis: Inherited or Acquired? Progr Hema 5:324-353, 1966. 5. Crosby, W.H., and MacDonald, R.A.: Controversy in Internal Medicine , Philadelphia: W. B. Saunders Company, 1966, pp 261-286. 6. Bothwell, T.H., and Finch, C.A.: Iron Metabolism , Boston: Little, Brown & Company, 1962. 7. Heilmeyer, L.: Pathogenesis of Hemochromatosis , Medicine 26:209-215 ( (March) ) 1967.Crossref 8. Finch, S.C., and Finch, C.A.: Idiopathic Hemochromatosis, an Iron Storage Disease , Medicine 34:381-430 ( (Dec) ) 1955.Crossref 9. Danehower, C.: Hemochromatosis , Bull Assoc Military Dermatologists 16:12-16 ( (Aug) ) 1967. 10. Richter, G.W.: The Nature of Hemosiderin Granules in Idiopathic Hemochromatosis: Electron Microscopy, Chemical and Serologic Studies , Amer J Path 35:690-691 ( (May) -June) 1959. 11. Richter, G.W.: The Nature of Storage Iron in Idiopathic Hemochromatosis and in Hemosiderosis: Electron Optical, Chemical and Serologic Studies on Isolated Hemosiderin Granules , J Exp Med 112:551-567 ( (Oct) ) 1960.Crossref 12. Blanc, B., and Vannotti, A.: Transferrin Behaviour in Haemochromatosis , Nature 212:480-481 ( (Oct 29) ) 1966.Crossref 13. Mazur, A., and Sackler, M.: Haemochromatosis and Hepatic Xanthine Oxidase , Lancet 1:254-255 ( (Feb 4) ) 1967.Crossref 14. Davis, P.S.; Luke, C.G.; and Deller, D.J.: Reduction of Gastric Iron-Binding Protein in Haemochromatosis , Lancet 2:1431-1433 ( (Dec 31) ) 1966.Crossref 15. Smith, P.M.; Studley, F.; and Williams, R.: Assessment of Body-Iron Stores in Cirrhosis and Haemochromatosis With the Differential Ferrioxamine Test , Lancet 1:133-136 ( (Jan 21) ) 1967.Crossref 16. Lillie, R.D.: Histopathologic Technic and Practical Histochemistry , New York: The Blakiston Company, Inc., 1954. 17. Spellberg, M.A.: Diseases of the Liver , New York: Grune & Stratton, Inc., 1954. 18. Gillman, J., and Gillman, T.: The Pathogenesis of Cytosiderosis (Hemochromatosis) as Evidenced in Malnourished Africans , Gastroenterology 8:19-23 ( (Jan) ) 1947. 19. Perdrup, A., and Poulsen, H.: Hemochromatosis and Vitiligo , Arch Derm 90:34-37 ( (July) ) 1964.Crossref 20. Hellier, F.F.: The Nature and Causation of the Skin Pigmentation in Haemochromatosis , Brit J Derm Syph 47:1-12 ( (Jan) ) 1935.Crossref 21. Lever, W.F.: Histopathology of the Skin , Philadelphia: J. B. Lippincott Company, 1967. 22. Robert, Von P., and Zürcher, H.: Pigmentstudien , Dermatologica 100:217-241, 1950.Crossref 23. Althausen, T.L., et al: Hemochromatosis , Arch Intern Med 88:553-570 ( (Nov) ) 1951.Crossref 24. Lerner, A.B., and Case, J.D.: Pigment Cell Regulatory Factors , J Invest Derm 32:211-221 ( (Feb) ) 1959.Crossref 25. Weintraub, L., et al: Iron Excretion by the Skin: Selective Localization of Iron59 in Epithelial Cells , Amer J Path 46:121-126 ( (Jan) ) 1965. 26. Magnuson, H.J., and Raulston, B.O.: The Iron Content of the Skin in Hemochromatosis , Ann Intern Med 16:687-693 ( (April) ) 1942.Crossref 27. Szabo, G., quoted in an editorial on Malignant Melanoma , Lancet 1:76-77 ( (Jan 13) ) 1968.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1969

References