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Hematoporphyrin Photoradiation Therapy for Intraocular and Orbital Malignant Melanoma

Hematoporphyrin Photoradiation Therapy for Intraocular and Orbital Malignant Melanoma Abstract • Photoradiation therapy (PRT) is a new technique that is currently under investigation for the treatment of a variety of solid malignant tumors. The technique involves systemic administration of hematoporphyrin derivative (HpD), a photosensitizing compound that is preferentially retained by malignant cells and photoactivation of the neoplasm with red light (630 nm) to achieve selective destruction of cancer cells. We used HpD PRT for seven patients with malignant melanoma of the uvea and conclude that initial results of HpD PRT for uveal malignant melanoma are encouraging and justify further investigation. References 1. Dougherty TJ: Activated dyes as anti-tumor agents . JNCI 1974;51:1333-1338. 2. Dougherty TJ, Kaufman JE, Goldfarb A, et al: Photoradiation therapy for the treatment of malignant tumors . Cancer Res 1978;38:2628-2635. 3. Weishaupt KR, Gomer CJ, Dougherty TJ: Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor . Cancer Res 1976;36:2316-2329. 4. Buettner GR, Oberley LW: The apparent production of superoxide and hydroxyl radicals by hematoporphyrin and light as seen by spintrapping . FEBS Lett 1980;121:161-164.Crossref 5. Doubleman TMAW, De Goeij AFPM, Van Steveninck J: Photodynamic effects of protoporphyrin on human erythrocytes . Biochim Biophys Acta 1978;511:141-151.Crossref 6. Girotti AW: Protoporphyrin-sensitized photodamage in isolated membranes of human erythrocytes . Biochem J 1979;18:4403-4411.Crossref 7. Goldstein BD, Harber LC: Erythropioetic protoporphyria: Lipid peroxidation and red cell membrane damage associated with photohemolysis . J Clin Invest 1972;51:892-902.Crossref 8. Kessel D: Effects of photoactivated prophyrins at the cell surface of leukemia L-1210 cells . Biochem J 1977;16:3443-3449.Crossref 9. Dougherty TJ, Lawrence G, Kaufman JE, et al: Photoradiation in the treatment of recurrent breast carcinoma . JNCI 1979;62:231-237. 10. Henderson BW, Dougherty TJ: Studies on the mechanism of tumor destruction by photoradiation therapy (PRT). Abstracts of the Clayton Foundation Symposium on Porphyrin Localization and Treatment of Tumors, Santa Barbara, Calif, April, 24-28, 1983. 11. Liu LHS, Ni C: Hematoporphyrin phototherapy for experimental intraocular malignant melanoma . Arch Ophthalmol 1983;101:901-903.Crossref 12. Dougherty TJ, Grindey GB, Fiel R, et al: Photoradiation therapy: II. Cure of animal tumors with hematoporphyrin and light . JNCI 1975;55:115-121. 13. Kelly JF, Snell ME: Hematoporphyrin derivative: A possible aid in the diagnosis and therapy of carcinoma of the bladder . J Urol 1976;115:150-151. 14. Forbes IJ, Cowled PA, Leong ASY, et al: Phototherapy of human tumors using hematoporphyrin derivative . Med J Aust 1980;2:489-493. 15. Laws ER Jr, Cortese DA, Kinsey JH, et al: Photoradiation therapy in the treatment of malignant brain tumors: a phase I (feasibility) study . Neurosurgery 1981;9:672-678.Crossref 16. Ward BG, Forbes IJ, Cowled PA, et al: The treatment of vaginal recurrences of gynecologic malignancy with phototherapy following hematoporphyrin derivative pretreatment . Am J Obstet Gynecol 1982;142:356-357. 17. Cortese DA, Kinsey JH: Endoscopic management of lung cancer with hematoporphyrin derivative phototherapy . Mayo Clin Proc 1982; 57:543-547. 18. Soma H, Akiya K, Nutahara S, et al: Treatment of vaginal carcinoma with laser photoradiation following administration of hematoporphyrin derivative . Ann Chir Gynaecol 1982; 71:133-136. 19. Dahlman A, Wile AG, Burns RG, et al: Laser photoradiation therapy of cancer . Cancer Res 1983;43:430-434. 20. Sery TW: Photodynamic killing of retinoblastoma cells with hematoporphyrin and light . Cancer Res 1979;39:96-100. 21. Benedict WF, Lingua RW, Doiron DR, et al: Tumor regression of human retinoblastoma in the nude mouse following photoradiation therapy: A preliminary report . Med Pediatr Oncol 1980;8:397.Crossref 22. Gomer CJ, Rucker N, Mark C, et al: Tissue distribution of 3H-hematoporphyrin derivative in athymic 'nude' mice heterotransplanted with human retinoblastoma . Invest Ophthalmol Vis Sci 1982;22:118-120. 23. Gomer CJ, Doiron DR, Jester JV, et al: Hematoporphyrin derivative photoradiation therapy for the treatment of intraocular tumors: Examination of acute normal ocular tissue toxicity . Cancer Res 1983;43:721-727. 24. Cunningham RD, Henderson JW: Experimental evaluation of hematoporphyrin in the detection and management of intraocular tumors . Am J Ophthalmol 1966;61:36-44. 25. Krohn DL, Jacobs R, Morris DA: Diagnosis of model choroidal malignant melanoma by hematoporphyrin fluorescence in rabbits . Invest Ophthalmol Vis Sci 1974;13:244-255. 26. Geeraets WJ, Williams RC, Ham GC Jr, et al: The relative absorption of thermal energy in retina and choroid . Invest Ophthalmol Vis Sci 1962;1:340-347. 27. Geeraets WJ, Berry ER: Ocular spectral characteristics as related to hazards from lasers and other light sources . Am J Ophthalmol 1968; 66:15-20. 28. Lewis RA, Tse DT, Phelps CD, et al: Neovascular glaucoma after photoradiation therapy for uveal melanoma . Arch Ophthalmol 1984; 102:839-842.Crossref 29. Bruce RA Jr: Evaluation of hematoporphyrin derivative to treat choroidal malignant melanoma. Read before the Fifth International Congress for Lasers in Medicine and Surgery, Oct 8, 1983, Detroit. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Hematoporphyrin Photoradiation Therapy for Intraocular and Orbital Malignant Melanoma

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030653011
Publisher site
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Abstract

Abstract • Photoradiation therapy (PRT) is a new technique that is currently under investigation for the treatment of a variety of solid malignant tumors. The technique involves systemic administration of hematoporphyrin derivative (HpD), a photosensitizing compound that is preferentially retained by malignant cells and photoactivation of the neoplasm with red light (630 nm) to achieve selective destruction of cancer cells. We used HpD PRT for seven patients with malignant melanoma of the uvea and conclude that initial results of HpD PRT for uveal malignant melanoma are encouraging and justify further investigation. References 1. Dougherty TJ: Activated dyes as anti-tumor agents . JNCI 1974;51:1333-1338. 2. Dougherty TJ, Kaufman JE, Goldfarb A, et al: Photoradiation therapy for the treatment of malignant tumors . Cancer Res 1978;38:2628-2635. 3. Weishaupt KR, Gomer CJ, Dougherty TJ: Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor . Cancer Res 1976;36:2316-2329. 4. Buettner GR, Oberley LW: The apparent production of superoxide and hydroxyl radicals by hematoporphyrin and light as seen by spintrapping . FEBS Lett 1980;121:161-164.Crossref 5. Doubleman TMAW, De Goeij AFPM, Van Steveninck J: Photodynamic effects of protoporphyrin on human erythrocytes . Biochim Biophys Acta 1978;511:141-151.Crossref 6. Girotti AW: Protoporphyrin-sensitized photodamage in isolated membranes of human erythrocytes . Biochem J 1979;18:4403-4411.Crossref 7. Goldstein BD, Harber LC: Erythropioetic protoporphyria: Lipid peroxidation and red cell membrane damage associated with photohemolysis . J Clin Invest 1972;51:892-902.Crossref 8. Kessel D: Effects of photoactivated prophyrins at the cell surface of leukemia L-1210 cells . Biochem J 1977;16:3443-3449.Crossref 9. Dougherty TJ, Lawrence G, Kaufman JE, et al: Photoradiation in the treatment of recurrent breast carcinoma . JNCI 1979;62:231-237. 10. Henderson BW, Dougherty TJ: Studies on the mechanism of tumor destruction by photoradiation therapy (PRT). Abstracts of the Clayton Foundation Symposium on Porphyrin Localization and Treatment of Tumors, Santa Barbara, Calif, April, 24-28, 1983. 11. Liu LHS, Ni C: Hematoporphyrin phototherapy for experimental intraocular malignant melanoma . Arch Ophthalmol 1983;101:901-903.Crossref 12. Dougherty TJ, Grindey GB, Fiel R, et al: Photoradiation therapy: II. Cure of animal tumors with hematoporphyrin and light . JNCI 1975;55:115-121. 13. Kelly JF, Snell ME: Hematoporphyrin derivative: A possible aid in the diagnosis and therapy of carcinoma of the bladder . J Urol 1976;115:150-151. 14. Forbes IJ, Cowled PA, Leong ASY, et al: Phototherapy of human tumors using hematoporphyrin derivative . Med J Aust 1980;2:489-493. 15. Laws ER Jr, Cortese DA, Kinsey JH, et al: Photoradiation therapy in the treatment of malignant brain tumors: a phase I (feasibility) study . Neurosurgery 1981;9:672-678.Crossref 16. Ward BG, Forbes IJ, Cowled PA, et al: The treatment of vaginal recurrences of gynecologic malignancy with phototherapy following hematoporphyrin derivative pretreatment . Am J Obstet Gynecol 1982;142:356-357. 17. Cortese DA, Kinsey JH: Endoscopic management of lung cancer with hematoporphyrin derivative phototherapy . Mayo Clin Proc 1982; 57:543-547. 18. Soma H, Akiya K, Nutahara S, et al: Treatment of vaginal carcinoma with laser photoradiation following administration of hematoporphyrin derivative . Ann Chir Gynaecol 1982; 71:133-136. 19. Dahlman A, Wile AG, Burns RG, et al: Laser photoradiation therapy of cancer . Cancer Res 1983;43:430-434. 20. Sery TW: Photodynamic killing of retinoblastoma cells with hematoporphyrin and light . Cancer Res 1979;39:96-100. 21. Benedict WF, Lingua RW, Doiron DR, et al: Tumor regression of human retinoblastoma in the nude mouse following photoradiation therapy: A preliminary report . Med Pediatr Oncol 1980;8:397.Crossref 22. Gomer CJ, Rucker N, Mark C, et al: Tissue distribution of 3H-hematoporphyrin derivative in athymic 'nude' mice heterotransplanted with human retinoblastoma . Invest Ophthalmol Vis Sci 1982;22:118-120. 23. Gomer CJ, Doiron DR, Jester JV, et al: Hematoporphyrin derivative photoradiation therapy for the treatment of intraocular tumors: Examination of acute normal ocular tissue toxicity . Cancer Res 1983;43:721-727. 24. Cunningham RD, Henderson JW: Experimental evaluation of hematoporphyrin in the detection and management of intraocular tumors . Am J Ophthalmol 1966;61:36-44. 25. Krohn DL, Jacobs R, Morris DA: Diagnosis of model choroidal malignant melanoma by hematoporphyrin fluorescence in rabbits . Invest Ophthalmol Vis Sci 1974;13:244-255. 26. Geeraets WJ, Williams RC, Ham GC Jr, et al: The relative absorption of thermal energy in retina and choroid . Invest Ophthalmol Vis Sci 1962;1:340-347. 27. Geeraets WJ, Berry ER: Ocular spectral characteristics as related to hazards from lasers and other light sources . Am J Ophthalmol 1968; 66:15-20. 28. Lewis RA, Tse DT, Phelps CD, et al: Neovascular glaucoma after photoradiation therapy for uveal melanoma . Arch Ophthalmol 1984; 102:839-842.Crossref 29. Bruce RA Jr: Evaluation of hematoporphyrin derivative to treat choroidal malignant melanoma. Read before the Fifth International Congress for Lasers in Medicine and Surgery, Oct 8, 1983, Detroit.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jun 1, 1984

References