Abstract A SURVEY of the literature shows hemangioendotheliosarcomas to be extremely rare tumors. They are especially rare when studies are confined to their occurrence in the larynx. This is a report of a case with wildly malignant disease and rapidly fatal outcome. Review of Literature Due to the irregular terminology and classification of these tumors in the literature, a systematic listing and analysis of the previously reported cases seems impossible. Therefore, certain highlights only will be noted.In 1892 Bosworth1 reviewed 46 cases of sarcoma of the larynx. The accuracy of the diagnosis is questionable in many instances.In 1908 Mallory2 first used the term hemangioendothelioma to describe a malignant vascular tumor placing responsibility for the aggressive growth on the endothelial cell.In 1924 Yankauer3 reported an angiosarcoma growing as a pedunculated lesion on one vocal cord.In 1929 Jackson reported 643 tumors of the larynx with no References 1. Bosworth, F.H.: " Sarcoma of the Larynx ," Diseases of the Nose and Throat , New York: William Wood & Co., 2:742, 1892. 2. Mallory, F.B.: The Results of the Application of Special Histological Methods to the Study of Tumors , J Exp Med 10:575-593, 1908.Crossref 3. Yankauer, S.: Angiosarcoma of the Larynx Removed by Indirect Laryngoscopy , Laryngoscope 34:488, 1924. 4. Havens, F.Z., and Parkhill, E.M.: Tumors of the Larynx Other Than Squamous Cell Epithelioma , Arch Otolaryng 34:1113-1122, 1941.Crossref 5. Stout, A.P.: Hemangio-endothelioma: Tumor of Blood Vessels Featuring Vascular Endothelial Cells , Ann Surg 118:445-464, ( (Sept) ) 1943.Crossref 6. Drucker, V.: Hemangioendothelioma: A Rare Malignant Tumor , Radiology 49:231-237, 1947.Crossref 7. McCarthy, W.D., and Pack, G.T.: Malignant Blood Vessel Tumors: A Report of 56 Cases of Angiosarcoma and Kaposi's Sarcoma , Surg Gynec Obstet 91:456-482, 1950. 8. Fink, H.E., and Oberman, H.A.: Hemangioendothelial Cell Sarcoma and Hemangiopericytoma , Amer J Roentgen 89:155-165 ( (Jan) ) 1963. 9. Broyles, E.N.: Presentation of Cases, Transactions of the 45th annual meeting of the American Broncho-Esophagological Association, p 46. 10. White, J., and Stewart, H.L.: Intestinal Adenocarcinoma and Intra-abdominal Hemangio-Endothelioma in Mice Ingesting Methylcholanthrene , J Natl Cancer Inst 3:331-347, 1942.
Archives of Otolaryngology – American Medical Association
Published: May 1, 1968
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