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Hemagglutination Inhibition Antibodies in Congenital Rubella Syndrome: A 17-Year Follow-up in the Ryukyu Islands

Hemagglutination Inhibition Antibodies in Congenital Rubella Syndrome: A 17-Year Follow-up in the... Abstract • We studied long-term rubella hemagglutination inhibition (HI) antibody titers in 381 children born between 1965 and 1966 with congenital rubella syndrome and in 344 of their mothers, who had had postnatally acquired rubella infection. Serum specimens were obtained 12 times during a 17-year period. The initial geometric mean titer of the rubella HI antibody was higher in the children than in their mothers, but the titer declined more rapidly in the children. After 17 years it was 25,4 in the children and 26,9 in the mothers. In 13 (3.4%) of the children, the rubella HI antibody titer reverted to negativity after three to 17 years. None of the mothers showed a reversion. (AJDC 1987;141:211-212) References 1. Ueda K, Nishida Y, Oshima K, et al: Seven-year follow-up study of rubella syndrome in Ryukyu with special reference to persistence of rubella hemagglutination inhibition antibodies . Jpn J Microbiol 1975;19:181-185.Crossref 2. Cooper LZ: Congenital rubella in the United States , in Krugman S, Gershon AA (eds): Infection of the Fetus and the Newborn Infant . New York, Alan R Liss Inc, 1975, pp 15-17. 3. Cooper LZ, Florman AL, Ziring PR, et al: Loss of rubella hemagglutination inhibition antibody in congenital rubella: Failure of seronegative children with congenital rubella respond to HPV-77 rubella vaccine . AJDC 1971; 122:397-403. 4. Hardy JP, Sever JL, Gilkeson MR: Declining antibody titers in children with congenital rubella . J Pediatr 1969;75:213-220.Crossref 5. Ueda K, Nishida Y, Oshima K, et al: An explanation for the high incidence of CRS in Ryukyu . Am J Epidemiol 1978;107:344-351. 6. Alford CA: Immunology of rubella , in Friedman H, Prier JE (eds): Rubella . Springfield, Ill, Charles C Thomas Publisher, 1973, pp 94-103. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Hemagglutination Inhibition Antibodies in Congenital Rubella Syndrome: A 17-Year Follow-up in the Ryukyu Islands

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460020101038
Publisher site
See Article on Publisher Site

Abstract

Abstract • We studied long-term rubella hemagglutination inhibition (HI) antibody titers in 381 children born between 1965 and 1966 with congenital rubella syndrome and in 344 of their mothers, who had had postnatally acquired rubella infection. Serum specimens were obtained 12 times during a 17-year period. The initial geometric mean titer of the rubella HI antibody was higher in the children than in their mothers, but the titer declined more rapidly in the children. After 17 years it was 25,4 in the children and 26,9 in the mothers. In 13 (3.4%) of the children, the rubella HI antibody titer reverted to negativity after three to 17 years. None of the mothers showed a reversion. (AJDC 1987;141:211-212) References 1. Ueda K, Nishida Y, Oshima K, et al: Seven-year follow-up study of rubella syndrome in Ryukyu with special reference to persistence of rubella hemagglutination inhibition antibodies . Jpn J Microbiol 1975;19:181-185.Crossref 2. Cooper LZ: Congenital rubella in the United States , in Krugman S, Gershon AA (eds): Infection of the Fetus and the Newborn Infant . New York, Alan R Liss Inc, 1975, pp 15-17. 3. Cooper LZ, Florman AL, Ziring PR, et al: Loss of rubella hemagglutination inhibition antibody in congenital rubella: Failure of seronegative children with congenital rubella respond to HPV-77 rubella vaccine . AJDC 1971; 122:397-403. 4. Hardy JP, Sever JL, Gilkeson MR: Declining antibody titers in children with congenital rubella . J Pediatr 1969;75:213-220.Crossref 5. Ueda K, Nishida Y, Oshima K, et al: An explanation for the high incidence of CRS in Ryukyu . Am J Epidemiol 1978;107:344-351. 6. Alford CA: Immunology of rubella , in Friedman H, Prier JE (eds): Rubella . Springfield, Ill, Charles C Thomas Publisher, 1973, pp 94-103.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1987

References