Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Heavy Chain Disease

Heavy Chain Disease Abstract To the Editor. —We read with interest the paper in the September issue1 on αheavy chain disease in which the pathological immunoglobulin disappeared with chemotherapy. The authors state that up to the time of acceptance of their paper all cases of so-called Mediterranean lymphoma and α-chain disease have occurred either in Arabs or oriental Jews in the Mediterranean basin. We have since then2 described 23 cases of abdominal lymphoma presenting with malabsorption and have subsequently had a further four cases in two of whom an α-heavy chain was demonstrated on immunological testing of the serum by B. Ramot in Tel Aviv. In one of these the pathological immunoglobulin disappeared on therapy.The patient, a 29-year-old mulatto man presented with a nine month history of steatorrhoea and abdominal pain. Investigations confirmed severe intestinal malab-sorption and a peroral jejunal biopsy showed villous atrophy with marked infiltration of the lamina propria by References 1. Zlotnick A, Levy M: α-Heavy chain disease: A variant of Mediterranean Lymphoma. Arch Intern Med 128:432-436,1971.Crossref 2. Novis BH, Bank S, Marks IN, et al: Abdominal lymphoma presenting with malabsorption. Quart J Med 40:521-540, 1971. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Loading next page...
 
/lp/american-medical-association/heavy-chain-disease-IKr4OE76PF
Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1972.00320050160024
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —We read with interest the paper in the September issue1 on αheavy chain disease in which the pathological immunoglobulin disappeared with chemotherapy. The authors state that up to the time of acceptance of their paper all cases of so-called Mediterranean lymphoma and α-chain disease have occurred either in Arabs or oriental Jews in the Mediterranean basin. We have since then2 described 23 cases of abdominal lymphoma presenting with malabsorption and have subsequently had a further four cases in two of whom an α-heavy chain was demonstrated on immunological testing of the serum by B. Ramot in Tel Aviv. In one of these the pathological immunoglobulin disappeared on therapy.The patient, a 29-year-old mulatto man presented with a nine month history of steatorrhoea and abdominal pain. Investigations confirmed severe intestinal malab-sorption and a peroral jejunal biopsy showed villous atrophy with marked infiltration of the lamina propria by References 1. Zlotnick A, Levy M: α-Heavy chain disease: A variant of Mediterranean Lymphoma. Arch Intern Med 128:432-436,1971.Crossref 2. Novis BH, Bank S, Marks IN, et al: Abdominal lymphoma presenting with malabsorption. Quart J Med 40:521-540, 1971.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1972

References