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Health Hazards of Formaldehyde

Health Hazards of Formaldehyde To the Editor.— The rapid growth of formaldehyde use has resulted in renewed interest in the health hazards of this compound. Two recent publications1 (1981;246:1677) discuss the consequences of formaldehyde toxicity. The incidence of squamous cell carcinoma in the nasal turbinates of rats and mice exposed to formaldehyde fumes and the incidence of small cell carcinoma of the lung among workers exposed to bischloromethyl ether, a combination of formaldehyde and hydrogen chloride, are of serious concern. Formaldehyde is beginning to be recognized as having mutagenic properties and as posing a carcinogenic risk to humans. We had an opportunity to study bone marrow chromosomal patterns from 40 patients who were undergoing maintenance hemodialysis. In this study we found marked chromosomal abnormalities, among them aneuploidies, chromosomal structural abnormalities, and chromosomal breaks.2 These abnormalities were seen in the metaphases from direct bone marrow preparations without prior culturing that suggests that the abnormalities http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Health Hazards of Formaldehyde

Goh, Kong-oo; Cestero, Rafael V. M.
JAMA , Volume 247 (20) – May 28, 1982
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Health Hazards of Formaldehyde

Abstract



To the Editor.—
The rapid growth of formaldehyde use has resulted in renewed interest in the health hazards of this compound. Two recent publications1 (1981;246:1677) discuss the consequences of formaldehyde toxicity. The incidence of squamous cell carcinoma in the nasal turbinates of rats and mice exposed to formaldehyde fumes and the incidence of small cell carcinoma of the lung among workers exposed to bischloromethyl ether, a combination of formaldehyde and hydrogen chloride, are...
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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1982.03320450016009
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— The rapid growth of formaldehyde use has resulted in renewed interest in the health hazards of this compound. Two recent publications1 (1981;246:1677) discuss the consequences of formaldehyde toxicity. The incidence of squamous cell carcinoma in the nasal turbinates of rats and mice exposed to formaldehyde fumes and the incidence of small cell carcinoma of the lung among workers exposed to bischloromethyl ether, a combination of formaldehyde and hydrogen chloride, are of serious concern. Formaldehyde is beginning to be recognized as having mutagenic properties and as posing a carcinogenic risk to humans. We had an opportunity to study bone marrow chromosomal patterns from 40 patients who were undergoing maintenance hemodialysis. In this study we found marked chromosomal abnormalities, among them aneuploidies, chromosomal structural abnormalities, and chromosomal breaks.2 These abnormalities were seen in the metaphases from direct bone marrow preparations without prior culturing that suggests that the abnormalities

Journal

JAMA – American Medical Association

Published: May 28, 1982

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