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Healing of Anorectal Wounds with Reference to Rectal Medication

Healing of Anorectal Wounds with Reference to Rectal Medication Abstract Under the impact of modern chemotherapy it became abundantly clear that potent therapeutic agents, such as the steroid hormones, when applied to the anogenital area in a vanishing type base (cream) exert a profound local pharmacologic effect, e. g., in pruritus. In numerous instances, when these same drugs are applied in an oleagenous ointment or grease base they are ineffective, and vice versa. These observations as well as subsequent studies led to our almost complete discontinuance of the topical application to the anogenital skin of drugs in oleagenous ointment, a vehicle which one of us had employed in the past.* In line with the foregoing and other observations, we instituted an investigation of the effects of various therapeutic agents in ointments and creams on the healing process of the anorectal wounds; to some of these agents healing-promoting qualities had been attributed by authors or in the promotion of marketed preparations. References 1. References 1 and 2. 2. References 3 and 5. 3. References 10 and 11. 4. Ginzburg, L.; Lyons, A. S.; Lesnick, G. J., and Maynard, A. de L.: Personal communications to the authors. 5. Stormont, R. T.: Personal communication to R. T., Dec. 23, 1952. 6. Turell, R.: Treatment in Proctology , Baltimore, Williams & Wilkins Company, 1949. 7. Turell, R.: Cod Liver Oil Ointment Therapy in Proctologic Disorders , New York J. Med. 50:2282 ( (Oct. 1) ) 1950. 8. Turell, R.: Hemorrhoidectomy with Special Reference to Open Versus Closed Technics , S. Clin. North America 32:677 ( (April) ) 1952. 9. Dann, L.; Glüchsmann, A., and Tansley, K.: Experimental Wounds Treated with Cod Liver Oil and Related Substances , Lancet 1:95, ( (Jan. 24) ) 1942.Crossref 10. Turell, R.: Surgical Treatment of Chronic Anal Fissure , Surg. Gynec. & Obst. 86:434 ( (April) ) 1948. 11. Turell, R.: Adenomas and Hemorrhoids: Problems of Rectal Bleeding , Wisconsin M. J. 54:413 ( (Sept.) ) 1955. 12. Boyd, W.: Pathology for the Surgeon , Ed. 7, Philadelphia, W. B. Saunders Company, 1955. 13. Turell, R.: Postoperative Anal Stenosis , Surg. Gynec. & Obst. 90:231 ( (Feb.) ) 1950. 14. Rosenberg, I.: Use of Hydrocortisone After Anorectal Surgery , A. M. A. Arch. Surg. 72:514 ( (March) ) 1956. 15. Lane, C. G., and Luikart, R. H. II: Dermatitis from Local Anesthetics, with Review of 107 Cases from Literature , J. A. M. A. 155:1046 ( (July 17) ) 1954. 16. Leifer, W.: Pruritus Ani , S. Clin. North America , 35:1479 ( (Oct.) ) 1955. 17. Turell, R.: Hydrocortisone Therapy in Control of Anogenital Pruritus , J. A. M. A. 158:173 ( (May 21) ) 1955. 18. Lenson, N.: Wound Healing: Role of Cod Liver Oil as a Tissue Stimulant , Am. J. Surg. 91:86 ( (Jan.) ) 1956. 19. Marks, M. M.: Cod Liver Oil in Proctologic Practice , Missouri Med. 52:187 ( (March) ) 1955. 20. Susnow, D. A.: Oleogranulomas of the Rectum Following Rectal Instillation of Petrolatum or Ointments Containing Petrolatum , Am. J. Surg. 83:496 ( (April) ) 1952. 21. Flesch, P.: Inhibition of Keratin Formation with Unsaturated Compounds , J. Invest. Dermat. 19:353 ( (Nov.) ) 1952. 22. Thimann, K. V.: Chlorophyll as Deodorant , J. A. M. A. 152:869 ( (June 27) ) 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

Healing of Anorectal Wounds with Reference to Rectal Medication

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1956.01280050138025
Publisher site
See Article on Publisher Site

Abstract

Abstract Under the impact of modern chemotherapy it became abundantly clear that potent therapeutic agents, such as the steroid hormones, when applied to the anogenital area in a vanishing type base (cream) exert a profound local pharmacologic effect, e. g., in pruritus. In numerous instances, when these same drugs are applied in an oleagenous ointment or grease base they are ineffective, and vice versa. These observations as well as subsequent studies led to our almost complete discontinuance of the topical application to the anogenital skin of drugs in oleagenous ointment, a vehicle which one of us had employed in the past.* In line with the foregoing and other observations, we instituted an investigation of the effects of various therapeutic agents in ointments and creams on the healing process of the anorectal wounds; to some of these agents healing-promoting qualities had been attributed by authors or in the promotion of marketed preparations. References 1. References 1 and 2. 2. References 3 and 5. 3. References 10 and 11. 4. Ginzburg, L.; Lyons, A. S.; Lesnick, G. J., and Maynard, A. de L.: Personal communications to the authors. 5. Stormont, R. T.: Personal communication to R. T., Dec. 23, 1952. 6. Turell, R.: Treatment in Proctology , Baltimore, Williams & Wilkins Company, 1949. 7. Turell, R.: Cod Liver Oil Ointment Therapy in Proctologic Disorders , New York J. Med. 50:2282 ( (Oct. 1) ) 1950. 8. Turell, R.: Hemorrhoidectomy with Special Reference to Open Versus Closed Technics , S. Clin. North America 32:677 ( (April) ) 1952. 9. Dann, L.; Glüchsmann, A., and Tansley, K.: Experimental Wounds Treated with Cod Liver Oil and Related Substances , Lancet 1:95, ( (Jan. 24) ) 1942.Crossref 10. Turell, R.: Surgical Treatment of Chronic Anal Fissure , Surg. Gynec. & Obst. 86:434 ( (April) ) 1948. 11. Turell, R.: Adenomas and Hemorrhoids: Problems of Rectal Bleeding , Wisconsin M. J. 54:413 ( (Sept.) ) 1955. 12. Boyd, W.: Pathology for the Surgeon , Ed. 7, Philadelphia, W. B. Saunders Company, 1955. 13. Turell, R.: Postoperative Anal Stenosis , Surg. Gynec. & Obst. 90:231 ( (Feb.) ) 1950. 14. Rosenberg, I.: Use of Hydrocortisone After Anorectal Surgery , A. M. A. Arch. Surg. 72:514 ( (March) ) 1956. 15. Lane, C. G., and Luikart, R. H. II: Dermatitis from Local Anesthetics, with Review of 107 Cases from Literature , J. A. M. A. 155:1046 ( (July 17) ) 1954. 16. Leifer, W.: Pruritus Ani , S. Clin. North America , 35:1479 ( (Oct.) ) 1955. 17. Turell, R.: Hydrocortisone Therapy in Control of Anogenital Pruritus , J. A. M. A. 158:173 ( (May 21) ) 1955. 18. Lenson, N.: Wound Healing: Role of Cod Liver Oil as a Tissue Stimulant , Am. J. Surg. 91:86 ( (Jan.) ) 1956. 19. Marks, M. M.: Cod Liver Oil in Proctologic Practice , Missouri Med. 52:187 ( (March) ) 1955. 20. Susnow, D. A.: Oleogranulomas of the Rectum Following Rectal Instillation of Petrolatum or Ointments Containing Petrolatum , Am. J. Surg. 83:496 ( (April) ) 1952. 21. Flesch, P.: Inhibition of Keratin Formation with Unsaturated Compounds , J. Invest. Dermat. 19:353 ( (Nov.) ) 1952. 22. Thimann, K. V.: Chlorophyll as Deodorant , J. A. M. A. 152:869 ( (June 27) ) 1953.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Nov 1, 1956

References

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