Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Hashimoto Encephalopathy

Hashimoto Encephalopathy BackgroundHashimoto encephalopathy has been described as a syndrome of encephalopathy and high serum antithyroid antibody concentrations that is responsive to glucocorticoid therapy, but these could be chance associations.ObjectiveTo study a patient with Hashimoto encephalopathy and to review the literature to determine whether Hashimoto encephalopathy is an identifiable syndrome.Data Sources and ExtractionWe searched the MEDLINE database to June 2002 for "Hashimoto" or "autoimmune thyroiditis" and "encephalopathy" and examined all identified articles and articles referenced therein, including all languages. We included all patients with noninfectious encephalopathy (clouding of consciousness and impaired cognitive function) and high serum antithyroid antibody concentrations. We excluded patients if they did not meet these inclusion criteria or if their symptoms could be explained by another neurologic disorder. We recorded clinical features and the results of imaging, electroencephalographic, thyroid function, and cerebrospinal fluid studies.Data SynthesisWe identified 85 patients (69 women and 16 men; mean age, 44 years) with encephalopathy and high serum antithyroid antibody concentrations. Among these patients, 23 (27%) had strokelike signs, 56 (66%) had seizures, 32 (38%) had psychosis, 66 (78%) had a high cerebrospinal fluid protein concentration, and 80 (98%) of 82 had abnormal electroencephalographic findings. Thyroid function varied from overt hypothyroidism to overt hyperthyroidism; the most common abnormality was subclinical hypothyroidism (30 patients [35%]). Among patients treated with glucocorticoids, 66 (96%) improved.ConclusionsThe combination of encephalopathy, high serum antithyroid antibody concentrations, and responsiveness to glucocorticoid therapy seems unlikely to be due to chance. However, there is no evidence of a pathogenic role for the antibodies, which are probably markers of some other autoimmune disorder affecting the brain.IN 1966, Brain and coworkersdescribed a patient with "Hashimoto's disease and encephalopathy." The patient was a 49-year-old man with hypothyroidism being treated with levothyroxine. He had slowly progressive impairment of consciousness interspersed with episodes of confusion or coma, often preceded by agitation, hallucinations, tremor, and cognitive loss. He also had recurrent strokelike episodes involving different vascular beds. Serum antithyroid microsomal and antithyroglobulin antibody concentrations were high, and he had histologically confirmed Hashimoto thyroiditis. Treatment with prednisone and an anticoagulant for 3 months was ineffective. Subsequently, his neurologic symptoms remitted while he was taking only levothyroxine. Brain et al(p514) concluded, "Antibody studies in future cases of unexplained encephalopathy should show whether we have described a syndrome or a coincidence."In the intervening 35 years, at least 105 patients have been reported as having Hashimoto encephalopathy.The clinical findings have varied, and some clinicians have proposed 2 subtypes of the disorder—a vasculitic type, characterized by multiple strokelike episodes, and a diffuse progressive type, characterized by dementia and psychiatric symptoms.Both forms may be accompanied by stupor or coma, tremor, seizures, or myoclonus.The etiology, pathogenesis, histopathologic characteristics, and range of clinical features, however, are unclear. Furthermore, the diagnosis, as described by Brain et al,depends on the presence of a high serum concentration of thyroid antibodies, but whether either the antibodies or concomitant thyroid dysfunction contributes to the pathogenesis of the neurologic disorder is not known. Indeed, the existence of the disorder itself has been questionedbecause of the high frequency of high serum antithyroid antibody concentrations in asymptomatic people and because there is no evidence of a causal link between the antibodies and encephalopathy.We describe a patient with encephalopathy and high serum antithyroid antibody concentrations. We also review all reported cases to determine whether the disorder is a definable entity.REPORT OF A PATIENTIn 1996, a 63-year-old woman had an episode of presumed viral encephalitis with subacute onset of impaired memory, ataxia, and headache. She had no focal motor, sensory, cranial nerve, or cerebellar abnormalities. Magnetic resonance images of the brain were normal. Results of cerebrospinal fluid (CSF) studies for viral and bacterial infection were negative. She was treated with acyclovir, intravenously, for possible herpes simplex encephalitis, and she improved.A few months later she developed tremor and cognitive dysfunction, which subsequently subsided. In 1999, cognitive dysfunction gradually recurred, she became increasingly confused, and she had a generalized seizure. Brain magnetic resonance images were normal. After a second seizure, she was given phosphenytoin, acyclovir, and ceftriaxone and was transferred to the Columbia-Presbyterian Medical Center, New York.On hospital admission, she was comatose. Brainstem reflexes were present, and painful stimuli resulted in extensor posturing of all limbs. Brain magnetic resonance images revealed diffuse, nonenhancing white matter hyperintensity, sparing the posterior fossa and deep gray nuclei (Figure 1). Treatment with intravenous valproic acid, phosphenytoin, mannitol, and methylprednisolone resulted in rapid improvement. She became oriented to place and time but was inattentive. Cranial nerve function was normal except for bilateral sixth nerve palsy. Tendon reflexes were brisk, but there were no upper or lower motor neuron signs, and sensation was normal.Baseline and follow-up axial T2-weighted magnetic resonance images of the brain of a woman with Hashimoto encephalopathy. A, The initial images show diffuse confluent hyperintense signal in the subcortical and periventricular deep white matter. The basal ganglia and thalami are uninvolved. B, The images 2 years later show complete resolution of the white matter abnormality.Hospital admission laboratory studies revealed a normal erythrocyte sedimentation rate; normal serum concentrations of lactate, angiotensin-converting enzyme, and complement; and negative test results for antinuclear, anti-DNA, antineutrophilic cytoplasmic, antimyelin-associated glycoprotein, anti-Yo, and anti-Hu antibodies. The CSF leukocyte count was 26 × 103/µL, the protein concentration was 0.098 g/dL, and viral and bacterial culture findings were negative. Serum thyrotropin and thyroxine concentrations were normal on hospital admission, but 2 weeks later her serum thyrotropin concentration was 5.6 mIU/L (reference range, 0.3-4.2 mIU/L) and her serum thyroxine concentration was 5.4 µg/dL (69 nmol/L) (reference range, 5.4-11.7 µg/dL [69-151 nmol/L]). She was not given levothyroxine. Serum antithyroglobulin antibodies were undetectable; serum antithyroid microsomal antibody concentrations were 400 and 1600 U/mL (reference, <1 U/mL). Brain biopsy findings revealed no evidence of infection, demyelination, or tumor; the only abnormality was small perivascular cuffs of lymphocytic cells. No perivascular demyelination was seen, and axonal staining was normal.With glucocorticoid therapy, she gradually improved; 15 months later, while taking prednisone (15 mg every other day), she was asymptomatic, and cognitive function was normal. Administration of the same dose of prednisone was continued, and she remained well at last evaluation (early 2002).LITERATURE REVIEWWe conducted a MEDLINE search using the words "Hashimoto" or "autoimmune thyroiditis" and "encephalopathy." We retrieved articles in all languages, and we reviewed references cited in these articles. We did not consider patients described in abstracts.We diagnosed Hashimoto encephalopathy if patients had the following 3 findings: clouding of consciousness with reduced wakefulness, attention, or cognitive function; no CSF evidence of bacterial or viral infection, as determined by culture or molecular analysis; and positive test results for or a high serum concentration (or titer) of antithyroid microsomal, antithyroid peroxidase, or antithyroglobulin antibodies. Patients with strokelike or postictal focal signs, seizures, dementia, or psychiatric symptoms were included if consciousness was depressed. Any CSF abnormality was acceptable as long as viral or bacterial infection was excluded. Any abnormalities in thyroid function and any thyroid or antithyroid therapy were acceptable as long as there was a high serum concentration (or titer) of antithyroid antibody. Patients were excluded if the case report did not contain adequate information to determine whether the illness met the inclusion criteria or if symptoms could be explained by brain tumor or stroke, as detected by imaging.We found studies of 105 patients with brain dysfunction associated with possible Hashimoto thyroiditis. We excluded 3 patients who did not have encephalopathy and in whom CSF was not analyzed; 1 patient lacking examination of the CSF; 13 who had no encephalopathy,including 6 patients with a purely cerebellar syndrome; and 2 in whom serum antithyroid antibodies were not measured.Two patients were described twice but are included only as single cases.Patients who met our criteria for the disorder were divided into subcategories based on the results of thyroid function tests (Table 1).Table 1. Categories of Thyroid Dysfunction in 85 Patients With Hashimoto EncephalopathyCategorySerum Thyrotropin LevelSerum Thyroxine LevelPatients, No. (%)Euthyroid, not taking thyroxineNormalNormal19 (22)Euthyroid, taking thyroxineNormalNormal7 (8)Subclinical hypothyroidismHighNormal30 (35)Overt hypothyroidismHighLow17 (20)Subclinical hyperthyroidismLowNormal2 (2)Overt hyperthyroidismLowHigh4 (5)Nonthyroidal illnessNormalLow1 (1)Thyroid function not reported. . .. . .5 (6)RESULTSWe identified 85 patients who met the inclusion criteria, including the patient described herein (Table 2). Their mean age at onset was 44 years (range, 9-78 years); 19 were boys or girls 18 years or younger. Among the adults, there were 53 women and 13 men.Table 2. Clinical Features of Patients With Hashimoto Encephalopathy*FeatureNormal Thyroid Function (n = 19)Normal Thyroid Function With Levothyroxine Sodium Therapy (n = 7)Subclinical Hypothyroidism (n = 30)Overt Hypothyroidism (n = 17)All† (n = 85)Female12 (63)7 (100)25 (83)15 (88)69 (81)Age, mean (range), y45 (14-73)30 (12-70)48 (12-78)41 (12-76)44 (9-78)Focal deficit7 (37)3 (43)6 (20)4 (24)23 (27)Seizures10 (53)6 (86)21 (70)12 (71)56 (66)Myoclonus6 (32)4 (57)15 (50)3 (18)32 (38)Psychosis8 (42)2 (29)12 (40)4 (24)31 (36)Relapsing-remitting course12 (63)6 (86)14 (47)11 (65)51 (60)High CSF protein concentration13 (68)4 (57)25 (83)14 (82)66 (78)Abnormal imaging findings9 (47)3 (43)17 (57)8 (47)40/82 (49)Abnormal EEG findings17/18 (94)7 (100)28 (93)16/16 (100)80/82 (98)Response to glucocorticoid therapy16/18 (89) (1 not treated)7 (100)22/23 (96) (7 not treated)12/12 (100) (5 not treated)67/70 (96) (15 not treated)Goiter4/8 (50)6/6 (100)4/5 (80)3/5 (60)24/39 (62)Serum anti-M present13/14 (93)5/5 (100)18/19 (95)10/10 (100)55/58 (95)Serum anti-TPO present4/4 (100)3/3 (100)10/10 (100)7/7 (100)26/26 (100)Serum anti-Tg present8/14 (57)4/4 (100)17/21 (81)8/13 (62)45/62 (73)Abbreviations: Anti-M, anti−thyroid microsomal antibody; anti-TPO, anti−thyroid peroxidase antibody; anti-Tg, antithyroglobulin antibody; CSF, cerebrospinal fluid; EEG, electroencephalographic.*Data are given as number (percentage) except where indicated otherwise.†Including all thyroid abnormalities or unknown thyroid status.NEUROLOGIC FEATURESAll patients had encephalopathy, as required. Additional findings were strokelike signs in 23 patients (27%) and seizures in 56 patients (66%) (Table 2), including status epilepticus (10 patients [12%]). The seizures were of all types—focal motor, tonic, generalized tonic-clonic, and myoclonic. Myoclonus was present in 32 patients (38%). Visual hallucinations or paranoid ideations were prominent in 31 patients (36%). The course was relapsing and remitting in 51 patients (60%). The findings were similar in patients of all ages.THYROID STATUSThyroid status varied greatly (Table 1). Neurologic symptoms and signs were similar in patients with normal serum thyroxine and thyrotropin concentrations (excluding patients taking levothyroxine); those being treated with levothyroxine on hospital admission and who therefore had been hypothyroid in the past; those with subclinical hypothyroidism and overt hypothyroidism on admission; and all patients (Table 2).The serum concentrations of thyroid antibodies also varied widely. Multiple antibodies were measured in 60 patients (71%); the value for 1 antibody was normal in 20 patients (24%). There was no relationship between the neurologic symptoms and signs and the type or serum concentration of antithyroid antibodies.NEUROLOGIC STUDIESIn 65 patients (76%), the CSF contained 0 to 3 nucleated cells/mm3; in 3 patients (4%), it contained more than 100 cells/mm3. The CSF protein concentration was high in 66 patients (78%), exceeding 0.01 g/dL in 18 patients (21%).Brain computed tomography or magnetic resonance imaging was performed in 82 patients (96%), of whom 40 (49%) had some abnormality: 11 had cerebral atrophy, 13 had nonspecific subcortical focal white matter abnormality, 8 had diffuse subcortical abnormality, 7 had focal cortical abnormality, and 1 had transient bilateral narrowing of a middle cerebral artery. Single-photon emission computed tomography findings were normal in 2 patients and showed focally decreased uptake in 8 and global hypoperfusion in 1.Electroencephalography was performed in 82 patients; 80 (98%) had some abnormality, most commonly diffuse slowing.OTHER AUTOIMMUNE DISEASEFew patients were tested for autoantibodies other than thyroid antibodies. Fourteen patients (16%) had nonspecific abnormalities: a high erythrocyte sedimentation rate, a high serum C-reactive protein concentration, or a high serum antinuclear antibody concentration. One patient had psoriatic arthritis and sicca syndrome,and 1 had sarcoidosis.PATHOLOGIC FINDINGSTwo patients underwent autopsy examination. The patient described by Brain et alwas autopsied 10 years after the original study, but brain findings were not mentioned.Autopsy in the other patient revealed lymphocytic infiltration of the veins of the brainstem.Two patients underwent a brain biopsy; 1 had lymphocytic infiltration of the walls of many small arterioles and venulesand the other (our patient) had perivascular cuffs of lymphocytic cells.CLINICAL COURSEThree patients died. The patient described by Brain et al had no neurologic symptoms at the time of death; the 2 other patients died while being treated with glucocorticoids.Of 85 patients, 45 were treated with glucocorticoids (some were already taking levothyroxine), and 44 (98%) improved. Twenty-four patients were treated with glucocorticoids and levothyroxine, of whom 22 (92%) improved. Twelve patients were treated with levothyroxine alone; 8 (67%) improved. The clinical characteristics of the patients who improved in response to treatment with glucocorticoids, glucocorticoids and levothyroxine, and levothyroxine were similar (Table 3). One patient was treated with glucocorticoids and carbimazole, 1 with anticonvulsant drugs, and 1 with plasma exchange (after failing glucocorticoid therapy); all 3 improved. Eight treated patients did not improve: 1 patient treated with glucocorticoids, 2 treated with glucocorticoids and levothyroxine, 4 treated with levothyroxine, and 1 treated with intravenous immunoglobulins. One patient received no treatment and did not improve.Table 3. Response of Patients With Hashimoto Encephalopathy to Therapy With Glucocorticoids, Glucocorticoids and Levothyroxine, and Levothyroxine*VariableImproved With Glucocorticoid TherapyImproved With Glucocorticoid and Levothyroxine Sodium TherapyImproved With Levothyroxine TherapyPatients treated, No.452412Patients improved, No.44228Female39 (89)16 (73)6 (75)Age, mean (range), y50 (12-78)41 (14-76)34 (12-59)Focal deficit15 (34)3 (14)1 (12)Seizures29 (66)15 (68)5 (62)Myoclonus21 (48)4 (18)5 (62)Psychosis19 (43)5 (23)4 (50)Relapsing-remitting course25 (57)16 (73)2 (25)High CSF protein concentration34 (77)18 (82)6 (75)Abnormal imaging findings20/43 (47)14/21 (67)2 (25)Abnormal EEG findings42/43 (98)21/21 (100)8 (100)Goiter13/20 (65)5/12 (42)1/3 (33)Euthyroid15 (34)1 (5)0Euthyroid with thyroid therapy7 (16)00Subclinical hypothyroidism12 (27)10 (45)5 (62)Overt hypothyroidism3 (7)9 (41)3 (38)Subclinical hyperthyroidism2 (5)00Overt hyperthyroidism3 (7)00Nonthyroidal illness01 (5)0Unclear thyroid status2 (5)1 (5)0Inflammatory marker5 (11)5 (23)0Abbreviations: CSF, cerebrospinal fluid; EEG, electroencephalographic.*Data are given as number (percentage) except where noted otherwise. Percentages are based on patients who responded to treatment.COMMENTThe term "Hashimoto encephalopathy" is used by neurologists to describe a syndrome of cerebral symptoms in patients with serologic evidence of autoimmune thyroid disease. It is clear from our survey that the neurologic and thyroid abnormalities are diverse, so much so that some researchershave questioned whether the patients all have the same disorder.In selecting case reports for review, we used simple criteria for diagnosis: encephalopathy and a high serum concentration of 1 antithyroid antibody, with no evidence of an infectious or other well-defined cerebral disorder. In patients who met these criteria, we then attempted to determine the variation in neurologic findings and whether these findings were related to different abnormalities of thyroid function.The authors of most case reports included "Hashimoto encephalopathy" in the titles of their articles, but approximately 20% of the patients did not meet our diagnostic criteria. Either the patient did not have an encephalopathy or thyroid antibodies were not reported. On the other hand, the 85 cases are a minimum number because we did not search for the key word "encephalopathy" alone and therefore we could have missed cases if the researchers considered a high serum concentration of antithyroid antibodies to be an incidental finding in a patient with encephalopathy and therefore did not diagnose Hashimoto encephalopathy. Moreover, we do not know the number of patients with encephalopathy and normal serum concentrations of antithyroid antibodies, which would be the ideal comparison group.ENCEPHALOPATHY AND THYROID DISEASEIs Hashimoto encephalopathy a distinct entity or an idiopathic encephalopathy in a patient who has a high serum concentration of antithyroid antibodies? Could the encephalopathy be caused by hypothyroidism, which is common in patients with high serum antithyroid antibody concentrations? Overt hypothyroidism can cause cerebral dysfunction, including decreases in alertness, mood, and cognition, and even psychosis ("myxedema madness") and coma.It can also cause low-amplitude electroencephalographic changes and high CSF protein concentrations. All these changes improve with levothyroxine therapy.Subclinical hypothyroidism has less, if any, effect on cerebral function, the electroencephalogram, and CSF protein content,and whether levothyroxine therapy is beneficial in patients with subclinical hypothyroidism is uncertain.Among the 85 patients who met our inclusion criteria, 47 (55%) had subclinical or overt hypothyroidism; 8 (17%) of these 47 patients improved in response to levothyroxine therapy, and 19 (40%) improved in response to levothyroxine and glucocorticoid therapy. However, some patients with hypothyroidism did not respond to levothyroxine therapy. Furthermore, the neurologic findings were similar in patients who were euthyroid, with or without continuing levothyroxine therapy, and those with subclinical or overt hypothyroidism (Table 2). In addition, 6 patients with encephalopathy had overt or subclinical hyperthyroidism. Considering the inconsistency of thyroid function, hypothyroidism alone cannot account for the encephalopathy.ENCEPHALOPATHY AND THYROID ANTIBODIESWhat is the relationship between high serum concentrations of antithyroid antibodies and encephalopathy? Hashimoto thyroiditis (Hashimoto disease) was first described as struma lymphomatosa (lymphomatous goiter) in 1912; it is now defined clinically by the presence of high serum concentrations of antithyroid antibodies and pathologically by lymphocytic infiltration, lymphoid germinal centers, and fibrosis in the thyroid gland. Goiter is an integral part of Hashimoto thyroiditis, but many clinicians use the term without reference to thyroid size; the generic term that includes goitrous and atrophic forms is "chronic autoimmune thyroiditis."Thyroid function may be normal, but it is often decreased, and, rarely, it is transiently increased.The hypothyroidism is thought to be caused primarily by T-cell cytotoxicity, but antibodies that block the action of thyrotropin are important in some patients. The commonly measured antibodies—antithyroid peroxidase antibodies (formerly called "antithyroid microsomal antibodies") and antithyroglobulin antibodies—have no biological activity. Both are usually present in high concentration, but a high concentration of either alone suffices for diagnosis of Hashimoto thyroiditis, and virtually all patients with high concentrations have pathologic evidence of thyroiditis.Some thyroglobulin is present in serum, but otherwise it and thyroid peroxidase are found only in thyroid tissue. There is no evidence that any antithyroid antibody reacts with brain tissue or affects nerve function.In population studies, the prevalence of high serum antithyroid antibody concentrations or pathologic evidence of thyroiditis ranges from 2% to 10% in young adults and 5% to 20% in older adults, especially women; it is even higher in people with subclinical hypothyroidism.High serum antithyroid antibody concentrations have been linked not only to encephalopathy but also to neuropathy and myopathy,depression,bipolar disease,and dementia.However, the high prevalence rates in healthy people and patients with subclinical hypothyroidism make it difficult to consider a high serum antithyroid antibody concentration as a defining feature of any disorder other than chronic autoimmune thyroiditis.Might the high serum antithyroid antibody concentrations be a response to exposure to proteins (viral, bacterial, or toxic) that injured the brain or to brain antigens released by injury that are structurally similar to thyroid peroxidase or thyroglobulin (molecular mimicry)? This possibility cannot be excluded, but there are no known exogenous or endogenous proteins that are structurally similar to the 2 thyroid proteins.ENCEPHALOPATHY AND GLUCOCORTICOID THERAPYMost patients with Hashimoto encephalopathy improved in association with, but not necessarily because of, glucocorticoid treatment. The patients who responded had no distinguishing clinical characteristics, but too few were treated in other ways for meaningful comparison. We believe that it is generally unwise to define a condition by response to a particular therapy, especially if the treatment is not a replacement for a specific deficit or directed against a specific target, although other researchershave included a beneficial response to glucocorticoid therapy as a criterion for the diagnosis of Hashimoto encephalopathy.ENCEPHALOPATHY AND OTHER AUTOIMMUNE DISORDERSMany patients who have autoimmune diseases have high serum concentrations of 1 or more antibodies directed against tissues not affected by the particular autoimmune disease. For example, patients with myasthenia gravis may have high serum antithyroid antibody concentrations.The presence of high serum antithyroid antibody concentrations in patients with Hashimoto encephalopathy could be another example of the same phenomenon, rather than indicating that the antibodies have any direct relationship to the cerebral disease. Also, patients with one autoimmune disease are at risk for 1 or more other autoimmune diseases.Several researchers have described patients with encephalopathy clinically similar to Hashimoto encephalopathy and high serum concentrations of antibodies to other self-antigens. One patient with myasthenia gravis had 2 episodes of unexplained encephalopathy.Five patients had an encephalopathy that improved with glucocorticoid therapy,but 1 of those patients had high serum antithyroid antibody concentrations compatible with Hashimoto encephalopathy; antithyroid antibodies were not mentioned in the other case reports. Four of the 5 patients had serologic evidence of another autoimmune disease, including high serum concentrations of rheumatoid factor, antinuclear antibodies, anti-RNA antibodies (SSA and SSB), or cardiolipin antibodies. Brain biopsy findings revealed only perivascular lymphocytic infiltration. The researchers postulated a syndrome of "nonvasculitic autoimmune inflammatory meningoencephalitis" associated with autoimmune diseases such as Sjögren syndrome and systemic lupus erythematosus.CONCLUSIONSBased on this review of cases of Hashimoto encephalopathy, we believe that the constellation of clinical manifestations constitutes a clinical syndrome. High serum antithyroid antibody concentrations are unlikely to be a chance association. Although there is no evidence that high antithyroid antibody concentrations have a role in pathogenesis, they could be a marker of some other autoimmune disorder. Given the lack of a comprehensible pathophysiologic link between antithyroid antibodies or Hashimoto thyroiditis and the cerebral syndrome, "Hashimoto encephalopathy" could be a misleading term, the disorder being one of a larger group of autoimmune encephalopathies. However, until the pathogenesis is understood, the eponym seems to be the most appropriate name for the condition because it links the only known identifier, a high serum concentration of antithyroid antibodies, to the encephalopathy.LBrainEHJellinekKBallHashimoto's disease and encephalopathy.Lancet.1966;2:512-514.SAlegreSARubioRRuiberrez de TorresEZamoraHashimoto encephalopathy [in Spanish].Med Clin (Barc).1998;10:437-438.AArainBAbou-KhalilHMosesHashimoto's encephalopathy: documentation of mesial temporal seizure origin by ictal EEG.Seizure.2001;10:438-441.FArchambeaudSGalinatYRegoubyHashimoto's encephalopathy: report of four cases.Rev Med Interne.2001;22:653-659.TAzumaTUemiciMFunauchiSDoiTMatsubaraMyelopathy associated with Hashimoto's disease.J Neurol Neurosurg Psychiatry.2000;68:679-683.PBalestriSGrossoGGaribaldiAlternating hemiplegia of childhood or Hashimoto's encephalopathy?J Neurol Neurosurg Psychiatry.1999;66:548-549.RBarkerJZajicekIWilkinsonThyrotoxic Hashimoto's encephalopathy [letter].J Neurol Neurosurg Psychiatry.1996;60:234.PMBoersJGColebatchHashimoto's encephalopathy responding to plasmapheresis [letter].J Neurol Neurosurg Psychiatry.2001;70:132.NIBohnenKJParnellCMHarperReversible MRI findings in a patient with Hashimoto's encephalopathy.Neurology.1997;49:246-247.SBostantjoboulousDZafiriouZKatsarouAKazisHashimoto's encephalopathy: clinical and laboratory findings.Funct Neurol.1996;11:247-251.OCByrneSMZuberiCAMadiganMDKingHashimoto's thyroiditis: a rare but treatable cause of encephalopathy in children.Eur J Paediatr Neurol.2000;4:279-282.ACantonOde FabregasMTintoreJMesaACodinaRSimoEncephalopathy associated to autoimmune thyroid disease: a more appropriate term for an underestimated condition?J Neurol Sci.2000;176:65-69.HCChenUMarsharaniHashimoto's encephalopathy.South Med J.2000;93:504-506.CClaussmannCOffnerYChevalierFSellalMCollardEncephalopathy and Hashimoto thyroiditis.Rev Neurol.1994;150:166-168.LCohenSMoulyPTassanCPierrot-DeseillignyA woman with a relapsing psychosis who got better with prednisone.Lancet.1996;347:1228.SCrozierPVerstichelCMassonPMNysMMassonCortico-dependent Hashimoto encephalitis.Presse Med.1994;23:1400-1401.JDesaiNWadiaHashimoto's encephalopathy.J Neurol Sci.1999;163:202-204.CMForchettiGKatsamakisDCGarronAutoimmune thyroiditis and a rapidly progressive dementia: global hypoperfusion on SPECT scanning suggests a possible mechanism.Neurology.1997;49:623-626.PGarrardJRHodgesPJDe VriesHashimoto's encephalopathy presenting as "myxodematous madness."J Neurol Neurosurg Psychiatry.2000;68:102-103.FGhawcheRBordetADesteeHashimoto's encephalopathy: toxic or autoimmune mechanism?Rev Neurol.1992;148:371-373.FGhika-SchmidJGhikaFRegliHashimoto's myoclonic encephalopathy: an underdiagnosed treatable condition?Mov Disord.1996;11:555-562.KGucuyenerASerdarogluABideciYYazmanASSoysalPCinazTremor and myoclonus heralding Hashimoto's encephalopathy.J Pediatr Endocrinol Metab.2000;13:1137-1141.MHartmannBSchanerKScheglmannABuckingRPfisterHashimoto encephalopathy: steroid-sensitive encephalopathy in Hashimoto thyroiditis.Nervenarzt.2000;71:489-494.RHencheyJCibulaWHelvestonJMaloneRLGilmoreElectroencephalographic findings in Hashimoto's encephalopathy.Neurology.1995;45:977-981.LEHernandez EchebarriaASaizFGrausDetection of 14-3-3 protein in the CSF of a patient with Hashimoto's encephalopathy.Neurology.2000;54:1539-1540.KIshiiAHayashiATamoakaHMisusawaSShojiA case of Hashimoto's encephalopathy with a relapsing course related to menstrual cycle.Rinsho Shinkeigaku.1993;33:995-997.KIshiiAHayashiATamoakaSUsukiHMizusawaSShojiCase report: thyrotropin-releasing hormone-induced myoclonus and tremor in a patient with Hashimoto's encephalopathy.Am J Med Sci.1995;310:202-205.UIsikRecurrent encephalopathy and seizures in an adolescent girl.Clin Pediatr.2001;40:273-275.EHJellinekKBallHashimoto's disease, encephalopathy, and splenic atrophy [letter].Lancet.1976;1:1248.IKothbauer-MargreiterMSturzeneggerJKomorRBaumgartnerCWHessEncephalopathy associated with Hashimoto thyroiditis: diagnosis and treatment.J Neurol.1996;243:585-593.DLatinvilleOBernardiJPCougouleHashimoto's thyroiditis and myoclonic encephalopathy: pathogenic hypothesis.Rev Neurol.1985;141:55-58.MMantoSGoldmanHBodurCerebellar syndrome associated with Hashimoto's encephalopathy.Rev Neurol.1996;152:202-204.DJMcCabeTBurkeSConnollyMHutchinsonAmnesic syndrome with bilateral mesial temporal lobe involvement in Hashimoto's encephalopathy.Neurology.2000;54:737-739.JMcGinleyDJMcCabeAFraserECaseyTRyanRMurphyHashimoto's encephalopathy: an unusual cause of status epilepticus.Ir Med J.2000;93:118.KWNolteAUnbehaunHSiekerTMKlossWPaulusHashimoto encephalopathy: a brainstem vasculitis?Neurology.2000;54:769-770.PPapathanasopoulosKMalliorisPKaranasiosDDimopoulosTPapapetropoulosFebrile Hashimoto's encephalopathy [letter].J Neurol Neurosurg Psychiatry.2000;68:795.RPeschen-RosinMSchabetJDichgansManifestation of Hashimoto's encephalopathy years before onset of thyroid disease.Eur Neurol.1999;41:79-84.MRQuerol PascualJJAguirre SanchezMRVelicia MataCGahete JimenezMCDuran HerreraFGonzalez DorregoHashimoto's encephalitis: a new case with spontaneous remission.Neurologia.2000;15:313-316.RQuilichiniAMateoMRobionFMazzerboDBaumeSBurteyHashimoto's encephalopathy: a new case [in French; letter].Presse Med.1996;25:687.ASawkaVFatourechiBBoeveBMokriRarity of encephalopathy associated with autoimmune thyroiditis: a case series from Mayo Clinic from 1950 to 1996.Thyroid.2002;12:393-398.MSeipeltIZerrRNauHashimoto's encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease.J Neurol Neurosurg Psychiatry.1999;66:172-176.MSelimDADrachmanAtaxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis.J Neurol Neurosurg Psychiatry.2001;71:81-87.PJShawTJWallsPKNewmanPGClelandNECartlidgeHashimoto's encephalopathy: a steroid-responsive disorder associated with high anti-thyroid antibody titers: report of 5 cases.Neurology.1991;41:228-233.MSheinAApterZDickermanSTyanoNGadothEncephalopathy in compensated Hashimoto thyroiditis: a clinical expression of autoimmune cerebral vasculitis.Brain Dev.1986;8:60-64.NShibataYYamamotoNSunamiMSugaYYamashitaIsolated angiitis of the CNS associated with Hashimoto's disease.Rinsho Shinkeigaku.1992;32:191-198.SSkoddaMKrausHDurwenWGehlenHashimoto's encephalopathy associated with isolated ACTH deficiency and hyponatremia: a case report.J Neurol.1999;246:970-971.CMSueJGMorrisAnother case of Hashimoto's encephalopathy.Mov Disord.1997;12:471-472.NSuzukiRMitamuraHOhmiHashimoto thyroiditis, distal renal tubular acidosis, pernicious anaemia and encephalopathy: a rare combination of auto-immune disorders in a 12-year-old girl.Eur J Pediatr.1994;153:78-79.CASybesmaEPinxteren-NaglerLGSinnigeJCvan OostromTWde VriesHashimoto encephalopathy in a 12-year-old girl.Eur J Pediatr.1999;158:867-868.STakahashiRMitamuraYItohNSuzukiAOkunoHashimoto encephalopathy: etiologic considerations.Pediatr Neurol.1994;11:328-331.DCThrushHGBoddieEpisodic encephalopathy associated with thyroid disorders.J Neurol Neurosurg Psychiatry.1974;37:696-700.JCvan OostromASchaafsmaRHaaxmaVariable manifestations of Hashimoto's encephalopathy.Ned Tijdschr Geneeskd.1999;143:1319-1322.EVasconcellosJEPina-GarzaTFakhouryGMFenichelPediatric manifestations of Hashimoto's encephalopathy.Pediatr Neurol.1999;20:394-398.AFVranckenKPBraunHWde ValkGJRinkelEpilepsy, disturbances of behavior and consciousness in the presence of normal thyroxine levels: still, consider the thyroid gland.Ned Tijdschr Geneesk.2000;144:5-8.NWatembergDWillisJMPellockEncephalopathy as the presenting symptom of Hashimoto's thyroiditis.J Child Neurol.2000;15:66-69.CWilhelm-GosslingKWeckbeckerEGBrabantRDenglerAutoimmune encephalopathy in Hashimoto's thyroiditis: a differential diagnosis in progressive dementia syndrome.Dtsch Med Wochenschr.1998;123:279-284.BVMaydellGKoppAKomorowskiHashimoto encephalopathy: is it underdiagnosed in pediatric patients?Neuropediatrics.2002;33:86-89.GSSunilCMariashHashimoto's encephalitis [letter].J Clin Endocrinol Metab.2001;86:947.LMHendersonPOBehanJAarliDHadleyITDraperHashimoto's encephalopathy: a new neuroimmunological syndrome.Ann Neurol.1987;22:140-141.PRCastilloBFBoeveRJCaselliSteroid responsive encephalopathy associated with thyroid autoimmunity: clinical and laboratory findings [abstract].Neurology.2002;58(suppl 3):A248.PCWhybrowBehavioral and psychiatric aspects of hypothyroidism.In: Braverman LE, Utiger RD, eds. The Thyroid: A Fundamental and Clinical Text.8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:837-842.ENystromAHambergerGLindstedtCLundquistCWikkelsoCerebrospinal fluid proteins in subclinical and overt hypothyroidism.Acta Neurol Scand.1997;95:311-314.DSRossSubclinical hypothyroidism.In: Braverman LE, Utiger RD, eds. The Thyroid: A Fundamental and Clinical Text.8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:1001-1006.HHashimotoZur Kenntniss der lymphomatosen Veranderung der Schilddruse (Struma lymphomatosa).Arch Klin Chir.1912;97:219-248.APWeetmanChronic autoimmune thyroiditis.In: Braverman LE, Utiger RD, eds. The Thyroid: A Fundamental and Clinical Text.8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:721-732.BBakerHGharibHMarkowitzCorrelation of thyroid antibodies and cytologic features in suspected autoimmune thyroid disease.Am J Med.1983;74:941-944.CSawinSTBigosSLandPBacharachRelationship between elevated serum thyrotropin level and thyroid antibodies in elderly patients.Am J Med.1985;79:591-595.MPVanderpumpWMTunbridgeJMFrenchThe incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey.Clin Endocrinol (Oxf).1995;43:55-68.YBaiNeuropathy and myopathy in patients with chronic lymphocytic thyroiditis.Acta Acad Med Sinicae.1990;12:296-299.CBNemeroffJSSimonJJHaggertyDLEvansAntithyroid antibodies in depressed patients.Am J Psychiatry.1985;142:840-843.JJHaggertySGSilvaMMarquardtPrevalence of antithyroid antibodies in mood disorders.Depress Anxiety.1997;5:91-96.OLopezBRabinJHuffDRezekOReinmuthSerum autoantibodies in patients with Alzheimer's disease and vascular dementia and in nondemented control subjects.Stroke.1992;23:1078-1083.SThorlaciusJAAarliTRiiseRMatreHJJohnsenAssociated disorders in myasthenia gravis: autoimmune diseases and their relation to thymectomy.Acta Neurol Scand.1989;80:290-295.DPyneDAIsenbergAutoimmune thyroid disease in systemic lupus erythematosus.Ann Rheum Dis.2002;61:70-72.DMaherVFritzAutoimmune encephalopathy after treatment of thymoma-associated myasthenia gravis.Br J Clin Pract.1996;50:406-407.RJCaselliBWScheithauerJDO'DuffyGCPetersonBFWestmorelandPADavenportChronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease.Mayo Clin Proc.1993;68:846-853.RJCaselliBFBoeveBWScheithauerJDO'DuffyGGHunderNonvasculitic autoimmune inflammatory meningoencephalitis (NAIM): a reversible form of encephalopathy.Neurology.1999;53:1579-1581.Corresponding author and reprints: Lewis P. Rowland, MD, Neurological Institute, Box 147, 710 W 168th St, New York, NY 10032 (e-mail: lpr1@columbia.edu).Accepted for publication July 12, 2002.Author contributions:Study concept and design (Drs Chong, Rowland, and Utiger);acquisition of data (Drs Chong, Rowland, and Utiger);analysis and interpretation of data (Drs Chong, Rowland, and Utiger);drafting of the manuscript (Dr Chong);critical revision of the manuscript for important intellectual content (Drs Rowland and Utiger);study supervision (Drs Rowland and Utiger).We thank Robert Barrett, MD, for caring for the patient described herein; Alex Khandji, MD, for interpreting the magnetic resonance images; and Alex Dranovsky, MD, PhD, Yutaka Nishigaki, Juan Pascual, MD, PhD, and H. Christian Schumacher, MD, PhD, for translations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Loading next page...
 
/lp/american-medical-association/hashimoto-encephalopathy-V3iDEnL6b0
Publisher
American Medical Association
Copyright
Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.60.2.164
Publisher site
See Article on Publisher Site

Abstract

BackgroundHashimoto encephalopathy has been described as a syndrome of encephalopathy and high serum antithyroid antibody concentrations that is responsive to glucocorticoid therapy, but these could be chance associations.ObjectiveTo study a patient with Hashimoto encephalopathy and to review the literature to determine whether Hashimoto encephalopathy is an identifiable syndrome.Data Sources and ExtractionWe searched the MEDLINE database to June 2002 for "Hashimoto" or "autoimmune thyroiditis" and "encephalopathy" and examined all identified articles and articles referenced therein, including all languages. We included all patients with noninfectious encephalopathy (clouding of consciousness and impaired cognitive function) and high serum antithyroid antibody concentrations. We excluded patients if they did not meet these inclusion criteria or if their symptoms could be explained by another neurologic disorder. We recorded clinical features and the results of imaging, electroencephalographic, thyroid function, and cerebrospinal fluid studies.Data SynthesisWe identified 85 patients (69 women and 16 men; mean age, 44 years) with encephalopathy and high serum antithyroid antibody concentrations. Among these patients, 23 (27%) had strokelike signs, 56 (66%) had seizures, 32 (38%) had psychosis, 66 (78%) had a high cerebrospinal fluid protein concentration, and 80 (98%) of 82 had abnormal electroencephalographic findings. Thyroid function varied from overt hypothyroidism to overt hyperthyroidism; the most common abnormality was subclinical hypothyroidism (30 patients [35%]). Among patients treated with glucocorticoids, 66 (96%) improved.ConclusionsThe combination of encephalopathy, high serum antithyroid antibody concentrations, and responsiveness to glucocorticoid therapy seems unlikely to be due to chance. However, there is no evidence of a pathogenic role for the antibodies, which are probably markers of some other autoimmune disorder affecting the brain.IN 1966, Brain and coworkersdescribed a patient with "Hashimoto's disease and encephalopathy." The patient was a 49-year-old man with hypothyroidism being treated with levothyroxine. He had slowly progressive impairment of consciousness interspersed with episodes of confusion or coma, often preceded by agitation, hallucinations, tremor, and cognitive loss. He also had recurrent strokelike episodes involving different vascular beds. Serum antithyroid microsomal and antithyroglobulin antibody concentrations were high, and he had histologically confirmed Hashimoto thyroiditis. Treatment with prednisone and an anticoagulant for 3 months was ineffective. Subsequently, his neurologic symptoms remitted while he was taking only levothyroxine. Brain et al(p514) concluded, "Antibody studies in future cases of unexplained encephalopathy should show whether we have described a syndrome or a coincidence."In the intervening 35 years, at least 105 patients have been reported as having Hashimoto encephalopathy.The clinical findings have varied, and some clinicians have proposed 2 subtypes of the disorder—a vasculitic type, characterized by multiple strokelike episodes, and a diffuse progressive type, characterized by dementia and psychiatric symptoms.Both forms may be accompanied by stupor or coma, tremor, seizures, or myoclonus.The etiology, pathogenesis, histopathologic characteristics, and range of clinical features, however, are unclear. Furthermore, the diagnosis, as described by Brain et al,depends on the presence of a high serum concentration of thyroid antibodies, but whether either the antibodies or concomitant thyroid dysfunction contributes to the pathogenesis of the neurologic disorder is not known. Indeed, the existence of the disorder itself has been questionedbecause of the high frequency of high serum antithyroid antibody concentrations in asymptomatic people and because there is no evidence of a causal link between the antibodies and encephalopathy.We describe a patient with encephalopathy and high serum antithyroid antibody concentrations. We also review all reported cases to determine whether the disorder is a definable entity.REPORT OF A PATIENTIn 1996, a 63-year-old woman had an episode of presumed viral encephalitis with subacute onset of impaired memory, ataxia, and headache. She had no focal motor, sensory, cranial nerve, or cerebellar abnormalities. Magnetic resonance images of the brain were normal. Results of cerebrospinal fluid (CSF) studies for viral and bacterial infection were negative. She was treated with acyclovir, intravenously, for possible herpes simplex encephalitis, and she improved.A few months later she developed tremor and cognitive dysfunction, which subsequently subsided. In 1999, cognitive dysfunction gradually recurred, she became increasingly confused, and she had a generalized seizure. Brain magnetic resonance images were normal. After a second seizure, she was given phosphenytoin, acyclovir, and ceftriaxone and was transferred to the Columbia-Presbyterian Medical Center, New York.On hospital admission, she was comatose. Brainstem reflexes were present, and painful stimuli resulted in extensor posturing of all limbs. Brain magnetic resonance images revealed diffuse, nonenhancing white matter hyperintensity, sparing the posterior fossa and deep gray nuclei (Figure 1). Treatment with intravenous valproic acid, phosphenytoin, mannitol, and methylprednisolone resulted in rapid improvement. She became oriented to place and time but was inattentive. Cranial nerve function was normal except for bilateral sixth nerve palsy. Tendon reflexes were brisk, but there were no upper or lower motor neuron signs, and sensation was normal.Baseline and follow-up axial T2-weighted magnetic resonance images of the brain of a woman with Hashimoto encephalopathy. A, The initial images show diffuse confluent hyperintense signal in the subcortical and periventricular deep white matter. The basal ganglia and thalami are uninvolved. B, The images 2 years later show complete resolution of the white matter abnormality.Hospital admission laboratory studies revealed a normal erythrocyte sedimentation rate; normal serum concentrations of lactate, angiotensin-converting enzyme, and complement; and negative test results for antinuclear, anti-DNA, antineutrophilic cytoplasmic, antimyelin-associated glycoprotein, anti-Yo, and anti-Hu antibodies. The CSF leukocyte count was 26 × 103/µL, the protein concentration was 0.098 g/dL, and viral and bacterial culture findings were negative. Serum thyrotropin and thyroxine concentrations were normal on hospital admission, but 2 weeks later her serum thyrotropin concentration was 5.6 mIU/L (reference range, 0.3-4.2 mIU/L) and her serum thyroxine concentration was 5.4 µg/dL (69 nmol/L) (reference range, 5.4-11.7 µg/dL [69-151 nmol/L]). She was not given levothyroxine. Serum antithyroglobulin antibodies were undetectable; serum antithyroid microsomal antibody concentrations were 400 and 1600 U/mL (reference, <1 U/mL). Brain biopsy findings revealed no evidence of infection, demyelination, or tumor; the only abnormality was small perivascular cuffs of lymphocytic cells. No perivascular demyelination was seen, and axonal staining was normal.With glucocorticoid therapy, she gradually improved; 15 months later, while taking prednisone (15 mg every other day), she was asymptomatic, and cognitive function was normal. Administration of the same dose of prednisone was continued, and she remained well at last evaluation (early 2002).LITERATURE REVIEWWe conducted a MEDLINE search using the words "Hashimoto" or "autoimmune thyroiditis" and "encephalopathy." We retrieved articles in all languages, and we reviewed references cited in these articles. We did not consider patients described in abstracts.We diagnosed Hashimoto encephalopathy if patients had the following 3 findings: clouding of consciousness with reduced wakefulness, attention, or cognitive function; no CSF evidence of bacterial or viral infection, as determined by culture or molecular analysis; and positive test results for or a high serum concentration (or titer) of antithyroid microsomal, antithyroid peroxidase, or antithyroglobulin antibodies. Patients with strokelike or postictal focal signs, seizures, dementia, or psychiatric symptoms were included if consciousness was depressed. Any CSF abnormality was acceptable as long as viral or bacterial infection was excluded. Any abnormalities in thyroid function and any thyroid or antithyroid therapy were acceptable as long as there was a high serum concentration (or titer) of antithyroid antibody. Patients were excluded if the case report did not contain adequate information to determine whether the illness met the inclusion criteria or if symptoms could be explained by brain tumor or stroke, as detected by imaging.We found studies of 105 patients with brain dysfunction associated with possible Hashimoto thyroiditis. We excluded 3 patients who did not have encephalopathy and in whom CSF was not analyzed; 1 patient lacking examination of the CSF; 13 who had no encephalopathy,including 6 patients with a purely cerebellar syndrome; and 2 in whom serum antithyroid antibodies were not measured.Two patients were described twice but are included only as single cases.Patients who met our criteria for the disorder were divided into subcategories based on the results of thyroid function tests (Table 1).Table 1. Categories of Thyroid Dysfunction in 85 Patients With Hashimoto EncephalopathyCategorySerum Thyrotropin LevelSerum Thyroxine LevelPatients, No. (%)Euthyroid, not taking thyroxineNormalNormal19 (22)Euthyroid, taking thyroxineNormalNormal7 (8)Subclinical hypothyroidismHighNormal30 (35)Overt hypothyroidismHighLow17 (20)Subclinical hyperthyroidismLowNormal2 (2)Overt hyperthyroidismLowHigh4 (5)Nonthyroidal illnessNormalLow1 (1)Thyroid function not reported. . .. . .5 (6)RESULTSWe identified 85 patients who met the inclusion criteria, including the patient described herein (Table 2). Their mean age at onset was 44 years (range, 9-78 years); 19 were boys or girls 18 years or younger. Among the adults, there were 53 women and 13 men.Table 2. Clinical Features of Patients With Hashimoto Encephalopathy*FeatureNormal Thyroid Function (n = 19)Normal Thyroid Function With Levothyroxine Sodium Therapy (n = 7)Subclinical Hypothyroidism (n = 30)Overt Hypothyroidism (n = 17)All† (n = 85)Female12 (63)7 (100)25 (83)15 (88)69 (81)Age, mean (range), y45 (14-73)30 (12-70)48 (12-78)41 (12-76)44 (9-78)Focal deficit7 (37)3 (43)6 (20)4 (24)23 (27)Seizures10 (53)6 (86)21 (70)12 (71)56 (66)Myoclonus6 (32)4 (57)15 (50)3 (18)32 (38)Psychosis8 (42)2 (29)12 (40)4 (24)31 (36)Relapsing-remitting course12 (63)6 (86)14 (47)11 (65)51 (60)High CSF protein concentration13 (68)4 (57)25 (83)14 (82)66 (78)Abnormal imaging findings9 (47)3 (43)17 (57)8 (47)40/82 (49)Abnormal EEG findings17/18 (94)7 (100)28 (93)16/16 (100)80/82 (98)Response to glucocorticoid therapy16/18 (89) (1 not treated)7 (100)22/23 (96) (7 not treated)12/12 (100) (5 not treated)67/70 (96) (15 not treated)Goiter4/8 (50)6/6 (100)4/5 (80)3/5 (60)24/39 (62)Serum anti-M present13/14 (93)5/5 (100)18/19 (95)10/10 (100)55/58 (95)Serum anti-TPO present4/4 (100)3/3 (100)10/10 (100)7/7 (100)26/26 (100)Serum anti-Tg present8/14 (57)4/4 (100)17/21 (81)8/13 (62)45/62 (73)Abbreviations: Anti-M, anti−thyroid microsomal antibody; anti-TPO, anti−thyroid peroxidase antibody; anti-Tg, antithyroglobulin antibody; CSF, cerebrospinal fluid; EEG, electroencephalographic.*Data are given as number (percentage) except where indicated otherwise.†Including all thyroid abnormalities or unknown thyroid status.NEUROLOGIC FEATURESAll patients had encephalopathy, as required. Additional findings were strokelike signs in 23 patients (27%) and seizures in 56 patients (66%) (Table 2), including status epilepticus (10 patients [12%]). The seizures were of all types—focal motor, tonic, generalized tonic-clonic, and myoclonic. Myoclonus was present in 32 patients (38%). Visual hallucinations or paranoid ideations were prominent in 31 patients (36%). The course was relapsing and remitting in 51 patients (60%). The findings were similar in patients of all ages.THYROID STATUSThyroid status varied greatly (Table 1). Neurologic symptoms and signs were similar in patients with normal serum thyroxine and thyrotropin concentrations (excluding patients taking levothyroxine); those being treated with levothyroxine on hospital admission and who therefore had been hypothyroid in the past; those with subclinical hypothyroidism and overt hypothyroidism on admission; and all patients (Table 2).The serum concentrations of thyroid antibodies also varied widely. Multiple antibodies were measured in 60 patients (71%); the value for 1 antibody was normal in 20 patients (24%). There was no relationship between the neurologic symptoms and signs and the type or serum concentration of antithyroid antibodies.NEUROLOGIC STUDIESIn 65 patients (76%), the CSF contained 0 to 3 nucleated cells/mm3; in 3 patients (4%), it contained more than 100 cells/mm3. The CSF protein concentration was high in 66 patients (78%), exceeding 0.01 g/dL in 18 patients (21%).Brain computed tomography or magnetic resonance imaging was performed in 82 patients (96%), of whom 40 (49%) had some abnormality: 11 had cerebral atrophy, 13 had nonspecific subcortical focal white matter abnormality, 8 had diffuse subcortical abnormality, 7 had focal cortical abnormality, and 1 had transient bilateral narrowing of a middle cerebral artery. Single-photon emission computed tomography findings were normal in 2 patients and showed focally decreased uptake in 8 and global hypoperfusion in 1.Electroencephalography was performed in 82 patients; 80 (98%) had some abnormality, most commonly diffuse slowing.OTHER AUTOIMMUNE DISEASEFew patients were tested for autoantibodies other than thyroid antibodies. Fourteen patients (16%) had nonspecific abnormalities: a high erythrocyte sedimentation rate, a high serum C-reactive protein concentration, or a high serum antinuclear antibody concentration. One patient had psoriatic arthritis and sicca syndrome,and 1 had sarcoidosis.PATHOLOGIC FINDINGSTwo patients underwent autopsy examination. The patient described by Brain et alwas autopsied 10 years after the original study, but brain findings were not mentioned.Autopsy in the other patient revealed lymphocytic infiltration of the veins of the brainstem.Two patients underwent a brain biopsy; 1 had lymphocytic infiltration of the walls of many small arterioles and venulesand the other (our patient) had perivascular cuffs of lymphocytic cells.CLINICAL COURSEThree patients died. The patient described by Brain et al had no neurologic symptoms at the time of death; the 2 other patients died while being treated with glucocorticoids.Of 85 patients, 45 were treated with glucocorticoids (some were already taking levothyroxine), and 44 (98%) improved. Twenty-four patients were treated with glucocorticoids and levothyroxine, of whom 22 (92%) improved. Twelve patients were treated with levothyroxine alone; 8 (67%) improved. The clinical characteristics of the patients who improved in response to treatment with glucocorticoids, glucocorticoids and levothyroxine, and levothyroxine were similar (Table 3). One patient was treated with glucocorticoids and carbimazole, 1 with anticonvulsant drugs, and 1 with plasma exchange (after failing glucocorticoid therapy); all 3 improved. Eight treated patients did not improve: 1 patient treated with glucocorticoids, 2 treated with glucocorticoids and levothyroxine, 4 treated with levothyroxine, and 1 treated with intravenous immunoglobulins. One patient received no treatment and did not improve.Table 3. Response of Patients With Hashimoto Encephalopathy to Therapy With Glucocorticoids, Glucocorticoids and Levothyroxine, and Levothyroxine*VariableImproved With Glucocorticoid TherapyImproved With Glucocorticoid and Levothyroxine Sodium TherapyImproved With Levothyroxine TherapyPatients treated, No.452412Patients improved, No.44228Female39 (89)16 (73)6 (75)Age, mean (range), y50 (12-78)41 (14-76)34 (12-59)Focal deficit15 (34)3 (14)1 (12)Seizures29 (66)15 (68)5 (62)Myoclonus21 (48)4 (18)5 (62)Psychosis19 (43)5 (23)4 (50)Relapsing-remitting course25 (57)16 (73)2 (25)High CSF protein concentration34 (77)18 (82)6 (75)Abnormal imaging findings20/43 (47)14/21 (67)2 (25)Abnormal EEG findings42/43 (98)21/21 (100)8 (100)Goiter13/20 (65)5/12 (42)1/3 (33)Euthyroid15 (34)1 (5)0Euthyroid with thyroid therapy7 (16)00Subclinical hypothyroidism12 (27)10 (45)5 (62)Overt hypothyroidism3 (7)9 (41)3 (38)Subclinical hyperthyroidism2 (5)00Overt hyperthyroidism3 (7)00Nonthyroidal illness01 (5)0Unclear thyroid status2 (5)1 (5)0Inflammatory marker5 (11)5 (23)0Abbreviations: CSF, cerebrospinal fluid; EEG, electroencephalographic.*Data are given as number (percentage) except where noted otherwise. Percentages are based on patients who responded to treatment.COMMENTThe term "Hashimoto encephalopathy" is used by neurologists to describe a syndrome of cerebral symptoms in patients with serologic evidence of autoimmune thyroid disease. It is clear from our survey that the neurologic and thyroid abnormalities are diverse, so much so that some researchershave questioned whether the patients all have the same disorder.In selecting case reports for review, we used simple criteria for diagnosis: encephalopathy and a high serum concentration of 1 antithyroid antibody, with no evidence of an infectious or other well-defined cerebral disorder. In patients who met these criteria, we then attempted to determine the variation in neurologic findings and whether these findings were related to different abnormalities of thyroid function.The authors of most case reports included "Hashimoto encephalopathy" in the titles of their articles, but approximately 20% of the patients did not meet our diagnostic criteria. Either the patient did not have an encephalopathy or thyroid antibodies were not reported. On the other hand, the 85 cases are a minimum number because we did not search for the key word "encephalopathy" alone and therefore we could have missed cases if the researchers considered a high serum concentration of antithyroid antibodies to be an incidental finding in a patient with encephalopathy and therefore did not diagnose Hashimoto encephalopathy. Moreover, we do not know the number of patients with encephalopathy and normal serum concentrations of antithyroid antibodies, which would be the ideal comparison group.ENCEPHALOPATHY AND THYROID DISEASEIs Hashimoto encephalopathy a distinct entity or an idiopathic encephalopathy in a patient who has a high serum concentration of antithyroid antibodies? Could the encephalopathy be caused by hypothyroidism, which is common in patients with high serum antithyroid antibody concentrations? Overt hypothyroidism can cause cerebral dysfunction, including decreases in alertness, mood, and cognition, and even psychosis ("myxedema madness") and coma.It can also cause low-amplitude electroencephalographic changes and high CSF protein concentrations. All these changes improve with levothyroxine therapy.Subclinical hypothyroidism has less, if any, effect on cerebral function, the electroencephalogram, and CSF protein content,and whether levothyroxine therapy is beneficial in patients with subclinical hypothyroidism is uncertain.Among the 85 patients who met our inclusion criteria, 47 (55%) had subclinical or overt hypothyroidism; 8 (17%) of these 47 patients improved in response to levothyroxine therapy, and 19 (40%) improved in response to levothyroxine and glucocorticoid therapy. However, some patients with hypothyroidism did not respond to levothyroxine therapy. Furthermore, the neurologic findings were similar in patients who were euthyroid, with or without continuing levothyroxine therapy, and those with subclinical or overt hypothyroidism (Table 2). In addition, 6 patients with encephalopathy had overt or subclinical hyperthyroidism. Considering the inconsistency of thyroid function, hypothyroidism alone cannot account for the encephalopathy.ENCEPHALOPATHY AND THYROID ANTIBODIESWhat is the relationship between high serum concentrations of antithyroid antibodies and encephalopathy? Hashimoto thyroiditis (Hashimoto disease) was first described as struma lymphomatosa (lymphomatous goiter) in 1912; it is now defined clinically by the presence of high serum concentrations of antithyroid antibodies and pathologically by lymphocytic infiltration, lymphoid germinal centers, and fibrosis in the thyroid gland. Goiter is an integral part of Hashimoto thyroiditis, but many clinicians use the term without reference to thyroid size; the generic term that includes goitrous and atrophic forms is "chronic autoimmune thyroiditis."Thyroid function may be normal, but it is often decreased, and, rarely, it is transiently increased.The hypothyroidism is thought to be caused primarily by T-cell cytotoxicity, but antibodies that block the action of thyrotropin are important in some patients. The commonly measured antibodies—antithyroid peroxidase antibodies (formerly called "antithyroid microsomal antibodies") and antithyroglobulin antibodies—have no biological activity. Both are usually present in high concentration, but a high concentration of either alone suffices for diagnosis of Hashimoto thyroiditis, and virtually all patients with high concentrations have pathologic evidence of thyroiditis.Some thyroglobulin is present in serum, but otherwise it and thyroid peroxidase are found only in thyroid tissue. There is no evidence that any antithyroid antibody reacts with brain tissue or affects nerve function.In population studies, the prevalence of high serum antithyroid antibody concentrations or pathologic evidence of thyroiditis ranges from 2% to 10% in young adults and 5% to 20% in older adults, especially women; it is even higher in people with subclinical hypothyroidism.High serum antithyroid antibody concentrations have been linked not only to encephalopathy but also to neuropathy and myopathy,depression,bipolar disease,and dementia.However, the high prevalence rates in healthy people and patients with subclinical hypothyroidism make it difficult to consider a high serum antithyroid antibody concentration as a defining feature of any disorder other than chronic autoimmune thyroiditis.Might the high serum antithyroid antibody concentrations be a response to exposure to proteins (viral, bacterial, or toxic) that injured the brain or to brain antigens released by injury that are structurally similar to thyroid peroxidase or thyroglobulin (molecular mimicry)? This possibility cannot be excluded, but there are no known exogenous or endogenous proteins that are structurally similar to the 2 thyroid proteins.ENCEPHALOPATHY AND GLUCOCORTICOID THERAPYMost patients with Hashimoto encephalopathy improved in association with, but not necessarily because of, glucocorticoid treatment. The patients who responded had no distinguishing clinical characteristics, but too few were treated in other ways for meaningful comparison. We believe that it is generally unwise to define a condition by response to a particular therapy, especially if the treatment is not a replacement for a specific deficit or directed against a specific target, although other researchershave included a beneficial response to glucocorticoid therapy as a criterion for the diagnosis of Hashimoto encephalopathy.ENCEPHALOPATHY AND OTHER AUTOIMMUNE DISORDERSMany patients who have autoimmune diseases have high serum concentrations of 1 or more antibodies directed against tissues not affected by the particular autoimmune disease. For example, patients with myasthenia gravis may have high serum antithyroid antibody concentrations.The presence of high serum antithyroid antibody concentrations in patients with Hashimoto encephalopathy could be another example of the same phenomenon, rather than indicating that the antibodies have any direct relationship to the cerebral disease. Also, patients with one autoimmune disease are at risk for 1 or more other autoimmune diseases.Several researchers have described patients with encephalopathy clinically similar to Hashimoto encephalopathy and high serum concentrations of antibodies to other self-antigens. One patient with myasthenia gravis had 2 episodes of unexplained encephalopathy.Five patients had an encephalopathy that improved with glucocorticoid therapy,but 1 of those patients had high serum antithyroid antibody concentrations compatible with Hashimoto encephalopathy; antithyroid antibodies were not mentioned in the other case reports. Four of the 5 patients had serologic evidence of another autoimmune disease, including high serum concentrations of rheumatoid factor, antinuclear antibodies, anti-RNA antibodies (SSA and SSB), or cardiolipin antibodies. Brain biopsy findings revealed only perivascular lymphocytic infiltration. The researchers postulated a syndrome of "nonvasculitic autoimmune inflammatory meningoencephalitis" associated with autoimmune diseases such as Sjögren syndrome and systemic lupus erythematosus.CONCLUSIONSBased on this review of cases of Hashimoto encephalopathy, we believe that the constellation of clinical manifestations constitutes a clinical syndrome. High serum antithyroid antibody concentrations are unlikely to be a chance association. Although there is no evidence that high antithyroid antibody concentrations have a role in pathogenesis, they could be a marker of some other autoimmune disorder. Given the lack of a comprehensible pathophysiologic link between antithyroid antibodies or Hashimoto thyroiditis and the cerebral syndrome, "Hashimoto encephalopathy" could be a misleading term, the disorder being one of a larger group of autoimmune encephalopathies. However, until the pathogenesis is understood, the eponym seems to be the most appropriate name for the condition because it links the only known identifier, a high serum concentration of antithyroid antibodies, to the encephalopathy.LBrainEHJellinekKBallHashimoto's disease and encephalopathy.Lancet.1966;2:512-514.SAlegreSARubioRRuiberrez de TorresEZamoraHashimoto encephalopathy [in Spanish].Med Clin (Barc).1998;10:437-438.AArainBAbou-KhalilHMosesHashimoto's encephalopathy: documentation of mesial temporal seizure origin by ictal EEG.Seizure.2001;10:438-441.FArchambeaudSGalinatYRegoubyHashimoto's encephalopathy: report of four cases.Rev Med Interne.2001;22:653-659.TAzumaTUemiciMFunauchiSDoiTMatsubaraMyelopathy associated with Hashimoto's disease.J Neurol Neurosurg Psychiatry.2000;68:679-683.PBalestriSGrossoGGaribaldiAlternating hemiplegia of childhood or Hashimoto's encephalopathy?J Neurol Neurosurg Psychiatry.1999;66:548-549.RBarkerJZajicekIWilkinsonThyrotoxic Hashimoto's encephalopathy [letter].J Neurol Neurosurg Psychiatry.1996;60:234.PMBoersJGColebatchHashimoto's encephalopathy responding to plasmapheresis [letter].J Neurol Neurosurg Psychiatry.2001;70:132.NIBohnenKJParnellCMHarperReversible MRI findings in a patient with Hashimoto's encephalopathy.Neurology.1997;49:246-247.SBostantjoboulousDZafiriouZKatsarouAKazisHashimoto's encephalopathy: clinical and laboratory findings.Funct Neurol.1996;11:247-251.OCByrneSMZuberiCAMadiganMDKingHashimoto's thyroiditis: a rare but treatable cause of encephalopathy in children.Eur J Paediatr Neurol.2000;4:279-282.ACantonOde FabregasMTintoreJMesaACodinaRSimoEncephalopathy associated to autoimmune thyroid disease: a more appropriate term for an underestimated condition?J Neurol Sci.2000;176:65-69.HCChenUMarsharaniHashimoto's encephalopathy.South Med J.2000;93:504-506.CClaussmannCOffnerYChevalierFSellalMCollardEncephalopathy and Hashimoto thyroiditis.Rev Neurol.1994;150:166-168.LCohenSMoulyPTassanCPierrot-DeseillignyA woman with a relapsing psychosis who got better with prednisone.Lancet.1996;347:1228.SCrozierPVerstichelCMassonPMNysMMassonCortico-dependent Hashimoto encephalitis.Presse Med.1994;23:1400-1401.JDesaiNWadiaHashimoto's encephalopathy.J Neurol Sci.1999;163:202-204.CMForchettiGKatsamakisDCGarronAutoimmune thyroiditis and a rapidly progressive dementia: global hypoperfusion on SPECT scanning suggests a possible mechanism.Neurology.1997;49:623-626.PGarrardJRHodgesPJDe VriesHashimoto's encephalopathy presenting as "myxodematous madness."J Neurol Neurosurg Psychiatry.2000;68:102-103.FGhawcheRBordetADesteeHashimoto's encephalopathy: toxic or autoimmune mechanism?Rev Neurol.1992;148:371-373.FGhika-SchmidJGhikaFRegliHashimoto's myoclonic encephalopathy: an underdiagnosed treatable condition?Mov Disord.1996;11:555-562.KGucuyenerASerdarogluABideciYYazmanASSoysalPCinazTremor and myoclonus heralding Hashimoto's encephalopathy.J Pediatr Endocrinol Metab.2000;13:1137-1141.MHartmannBSchanerKScheglmannABuckingRPfisterHashimoto encephalopathy: steroid-sensitive encephalopathy in Hashimoto thyroiditis.Nervenarzt.2000;71:489-494.RHencheyJCibulaWHelvestonJMaloneRLGilmoreElectroencephalographic findings in Hashimoto's encephalopathy.Neurology.1995;45:977-981.LEHernandez EchebarriaASaizFGrausDetection of 14-3-3 protein in the CSF of a patient with Hashimoto's encephalopathy.Neurology.2000;54:1539-1540.KIshiiAHayashiATamoakaHMisusawaSShojiA case of Hashimoto's encephalopathy with a relapsing course related to menstrual cycle.Rinsho Shinkeigaku.1993;33:995-997.KIshiiAHayashiATamoakaSUsukiHMizusawaSShojiCase report: thyrotropin-releasing hormone-induced myoclonus and tremor in a patient with Hashimoto's encephalopathy.Am J Med Sci.1995;310:202-205.UIsikRecurrent encephalopathy and seizures in an adolescent girl.Clin Pediatr.2001;40:273-275.EHJellinekKBallHashimoto's disease, encephalopathy, and splenic atrophy [letter].Lancet.1976;1:1248.IKothbauer-MargreiterMSturzeneggerJKomorRBaumgartnerCWHessEncephalopathy associated with Hashimoto thyroiditis: diagnosis and treatment.J Neurol.1996;243:585-593.DLatinvilleOBernardiJPCougouleHashimoto's thyroiditis and myoclonic encephalopathy: pathogenic hypothesis.Rev Neurol.1985;141:55-58.MMantoSGoldmanHBodurCerebellar syndrome associated with Hashimoto's encephalopathy.Rev Neurol.1996;152:202-204.DJMcCabeTBurkeSConnollyMHutchinsonAmnesic syndrome with bilateral mesial temporal lobe involvement in Hashimoto's encephalopathy.Neurology.2000;54:737-739.JMcGinleyDJMcCabeAFraserECaseyTRyanRMurphyHashimoto's encephalopathy: an unusual cause of status epilepticus.Ir Med J.2000;93:118.KWNolteAUnbehaunHSiekerTMKlossWPaulusHashimoto encephalopathy: a brainstem vasculitis?Neurology.2000;54:769-770.PPapathanasopoulosKMalliorisPKaranasiosDDimopoulosTPapapetropoulosFebrile Hashimoto's encephalopathy [letter].J Neurol Neurosurg Psychiatry.2000;68:795.RPeschen-RosinMSchabetJDichgansManifestation of Hashimoto's encephalopathy years before onset of thyroid disease.Eur Neurol.1999;41:79-84.MRQuerol PascualJJAguirre SanchezMRVelicia MataCGahete JimenezMCDuran HerreraFGonzalez DorregoHashimoto's encephalitis: a new case with spontaneous remission.Neurologia.2000;15:313-316.RQuilichiniAMateoMRobionFMazzerboDBaumeSBurteyHashimoto's encephalopathy: a new case [in French; letter].Presse Med.1996;25:687.ASawkaVFatourechiBBoeveBMokriRarity of encephalopathy associated with autoimmune thyroiditis: a case series from Mayo Clinic from 1950 to 1996.Thyroid.2002;12:393-398.MSeipeltIZerrRNauHashimoto's encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease.J Neurol Neurosurg Psychiatry.1999;66:172-176.MSelimDADrachmanAtaxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis.J Neurol Neurosurg Psychiatry.2001;71:81-87.PJShawTJWallsPKNewmanPGClelandNECartlidgeHashimoto's encephalopathy: a steroid-responsive disorder associated with high anti-thyroid antibody titers: report of 5 cases.Neurology.1991;41:228-233.MSheinAApterZDickermanSTyanoNGadothEncephalopathy in compensated Hashimoto thyroiditis: a clinical expression of autoimmune cerebral vasculitis.Brain Dev.1986;8:60-64.NShibataYYamamotoNSunamiMSugaYYamashitaIsolated angiitis of the CNS associated with Hashimoto's disease.Rinsho Shinkeigaku.1992;32:191-198.SSkoddaMKrausHDurwenWGehlenHashimoto's encephalopathy associated with isolated ACTH deficiency and hyponatremia: a case report.J Neurol.1999;246:970-971.CMSueJGMorrisAnother case of Hashimoto's encephalopathy.Mov Disord.1997;12:471-472.NSuzukiRMitamuraHOhmiHashimoto thyroiditis, distal renal tubular acidosis, pernicious anaemia and encephalopathy: a rare combination of auto-immune disorders in a 12-year-old girl.Eur J Pediatr.1994;153:78-79.CASybesmaEPinxteren-NaglerLGSinnigeJCvan OostromTWde VriesHashimoto encephalopathy in a 12-year-old girl.Eur J Pediatr.1999;158:867-868.STakahashiRMitamuraYItohNSuzukiAOkunoHashimoto encephalopathy: etiologic considerations.Pediatr Neurol.1994;11:328-331.DCThrushHGBoddieEpisodic encephalopathy associated with thyroid disorders.J Neurol Neurosurg Psychiatry.1974;37:696-700.JCvan OostromASchaafsmaRHaaxmaVariable manifestations of Hashimoto's encephalopathy.Ned Tijdschr Geneeskd.1999;143:1319-1322.EVasconcellosJEPina-GarzaTFakhouryGMFenichelPediatric manifestations of Hashimoto's encephalopathy.Pediatr Neurol.1999;20:394-398.AFVranckenKPBraunHWde ValkGJRinkelEpilepsy, disturbances of behavior and consciousness in the presence of normal thyroxine levels: still, consider the thyroid gland.Ned Tijdschr Geneesk.2000;144:5-8.NWatembergDWillisJMPellockEncephalopathy as the presenting symptom of Hashimoto's thyroiditis.J Child Neurol.2000;15:66-69.CWilhelm-GosslingKWeckbeckerEGBrabantRDenglerAutoimmune encephalopathy in Hashimoto's thyroiditis: a differential diagnosis in progressive dementia syndrome.Dtsch Med Wochenschr.1998;123:279-284.BVMaydellGKoppAKomorowskiHashimoto encephalopathy: is it underdiagnosed in pediatric patients?Neuropediatrics.2002;33:86-89.GSSunilCMariashHashimoto's encephalitis [letter].J Clin Endocrinol Metab.2001;86:947.LMHendersonPOBehanJAarliDHadleyITDraperHashimoto's encephalopathy: a new neuroimmunological syndrome.Ann Neurol.1987;22:140-141.PRCastilloBFBoeveRJCaselliSteroid responsive encephalopathy associated with thyroid autoimmunity: clinical and laboratory findings [abstract].Neurology.2002;58(suppl 3):A248.PCWhybrowBehavioral and psychiatric aspects of hypothyroidism.In: Braverman LE, Utiger RD, eds. The Thyroid: A Fundamental and Clinical Text.8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:837-842.ENystromAHambergerGLindstedtCLundquistCWikkelsoCerebrospinal fluid proteins in subclinical and overt hypothyroidism.Acta Neurol Scand.1997;95:311-314.DSRossSubclinical hypothyroidism.In: Braverman LE, Utiger RD, eds. The Thyroid: A Fundamental and Clinical Text.8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:1001-1006.HHashimotoZur Kenntniss der lymphomatosen Veranderung der Schilddruse (Struma lymphomatosa).Arch Klin Chir.1912;97:219-248.APWeetmanChronic autoimmune thyroiditis.In: Braverman LE, Utiger RD, eds. The Thyroid: A Fundamental and Clinical Text.8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:721-732.BBakerHGharibHMarkowitzCorrelation of thyroid antibodies and cytologic features in suspected autoimmune thyroid disease.Am J Med.1983;74:941-944.CSawinSTBigosSLandPBacharachRelationship between elevated serum thyrotropin level and thyroid antibodies in elderly patients.Am J Med.1985;79:591-595.MPVanderpumpWMTunbridgeJMFrenchThe incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey.Clin Endocrinol (Oxf).1995;43:55-68.YBaiNeuropathy and myopathy in patients with chronic lymphocytic thyroiditis.Acta Acad Med Sinicae.1990;12:296-299.CBNemeroffJSSimonJJHaggertyDLEvansAntithyroid antibodies in depressed patients.Am J Psychiatry.1985;142:840-843.JJHaggertySGSilvaMMarquardtPrevalence of antithyroid antibodies in mood disorders.Depress Anxiety.1997;5:91-96.OLopezBRabinJHuffDRezekOReinmuthSerum autoantibodies in patients with Alzheimer's disease and vascular dementia and in nondemented control subjects.Stroke.1992;23:1078-1083.SThorlaciusJAAarliTRiiseRMatreHJJohnsenAssociated disorders in myasthenia gravis: autoimmune diseases and their relation to thymectomy.Acta Neurol Scand.1989;80:290-295.DPyneDAIsenbergAutoimmune thyroid disease in systemic lupus erythematosus.Ann Rheum Dis.2002;61:70-72.DMaherVFritzAutoimmune encephalopathy after treatment of thymoma-associated myasthenia gravis.Br J Clin Pract.1996;50:406-407.RJCaselliBWScheithauerJDO'DuffyGCPetersonBFWestmorelandPADavenportChronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease.Mayo Clin Proc.1993;68:846-853.RJCaselliBFBoeveBWScheithauerJDO'DuffyGGHunderNonvasculitic autoimmune inflammatory meningoencephalitis (NAIM): a reversible form of encephalopathy.Neurology.1999;53:1579-1581.Corresponding author and reprints: Lewis P. Rowland, MD, Neurological Institute, Box 147, 710 W 168th St, New York, NY 10032 (e-mail: lpr1@columbia.edu).Accepted for publication July 12, 2002.Author contributions:Study concept and design (Drs Chong, Rowland, and Utiger);acquisition of data (Drs Chong, Rowland, and Utiger);analysis and interpretation of data (Drs Chong, Rowland, and Utiger);drafting of the manuscript (Dr Chong);critical revision of the manuscript for important intellectual content (Drs Rowland and Utiger);study supervision (Drs Rowland and Utiger).We thank Robert Barrett, MD, for caring for the patient described herein; Alex Khandji, MD, for interpreting the magnetic resonance images; and Alex Dranovsky, MD, PhD, Yutaka Nishigaki, Juan Pascual, MD, PhD, and H. Christian Schumacher, MD, PhD, for translations.

Journal

JAMA NeurologyAmerican Medical Association

Published: Feb 1, 2003

References