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Handbook of Diseases of Aging

Handbook of Diseases of Aging Dr Herman Blumenthal emphasizes in his introduction that this volume is not about the basic biology of aging or clinical geriatrics. It is about "disease causality as possibly directly related to biologic aging." As such, it is a provocative and brilliant multiauthored volume containing a wealth of research and theoretical information on the relationship between aging and disease. Dr Blumenthal hypothesizes that the aging process, at a molecular level, represents an accumulation over time of errors in intracellular information flow, with transcription and translation "mistakes," resulting in the production of misspecified proteins. These cybernetic alterations result in cellular dysfunctions, which combine with environmental risk factors to produce a high incidence of certain diseases in the elderly (cancer, arteriosclerosis, autoimmune diseases, diabetes mellitus, hypertension, and Alzheimer's disease). Twenty-five prominent investigators thoroughly discuss these pathological states, not so much from the viewpoint of proving this hypothesis, but instead to provide an objective http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Handbook of Diseases of Aging

JAMA , Volume 252 (11) – Sep 21, 1984

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1984.03350110068037
Publisher site
See Article on Publisher Site

Abstract

Dr Herman Blumenthal emphasizes in his introduction that this volume is not about the basic biology of aging or clinical geriatrics. It is about "disease causality as possibly directly related to biologic aging." As such, it is a provocative and brilliant multiauthored volume containing a wealth of research and theoretical information on the relationship between aging and disease. Dr Blumenthal hypothesizes that the aging process, at a molecular level, represents an accumulation over time of errors in intracellular information flow, with transcription and translation "mistakes," resulting in the production of misspecified proteins. These cybernetic alterations result in cellular dysfunctions, which combine with environmental risk factors to produce a high incidence of certain diseases in the elderly (cancer, arteriosclerosis, autoimmune diseases, diabetes mellitus, hypertension, and Alzheimer's disease). Twenty-five prominent investigators thoroughly discuss these pathological states, not so much from the viewpoint of proving this hypothesis, but instead to provide an objective

Journal

JAMAAmerican Medical Association

Published: Sep 21, 1984

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