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Haemophilus influenzae Type b Infections

Haemophilus influenzae Type b Infections Abstract Sir.—The current interest in the literature1-4 in the spread of Haemophilus type b infections prompted us to add our recent experience with this problem that tends to confirm previous observations. Three infants, ages of 10 and 17 months, were admitted within an eight-day period with serious Haemophilus influenzae type b infections, two with bacterial meningitis and one with cellulitis of the cheek (cases 1, 2, 3, Table). The three infants were among five children younger than 2 years of age cared for during the day, as a group, in a small apartment by one grandmother babysitter. This striking coincidence of disease prompted an epidemiological investigation of immediate contacts including history, physical examination, nasopharyngeal cultures, and paired serum determinations for capsular antibody titers by radioimmunoassay technique. A total of 17 individuals were studied. The positive findings are shown in the accompanying Table. It was noted that one of the References 1. Tejani A, Bohdan D, Nangia BS, et al: Intrafamily spread of Haemophilus type b infection . Am J Dis Child 131:778-781, 1977. 2. Ginsburg CM, McCracken GH Jr, Rae S, et al: Haemophilus influenzae type b disease: Incidence in a day care center . JAMA 238:604-607, 1977.Crossref 3. Melish ME, Nelson AJ, Martin TE, et al: Epidemic spread of H influenzae type b (HIB) in a day care center . Pediatr Res 10:348, 1976. 4. Glode MP, Schiffer MS, Robbins JB, et al: An outbreak of Hemophilus influenzae type b meningitis in an enclosed hospital population . J Pediatr 88:36-40, 1976.Crossref 5. Norden CW, Michaels RH, Melish M: Serologic responses of children with meningitis due to Haemophilus influenzae type b . J Infect Dis 134:495-499, 1976.Crossref 6. Smith DH, Peter G, Ingram DL, Harding AL, et al: Responses of children immunized with the capsular polysaccharide of Hemophilus influenzae type b . Pediatrics 52:637-644, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Haemophilus influenzae Type b Infections

Abstract

Abstract Sir.—The current interest in the literature1-4 in the spread of Haemophilus type b infections prompted us to add our recent experience with this problem that tends to confirm previous observations. Three infants, ages of 10 and 17 months, were admitted within an eight-day period with serious Haemophilus influenzae type b infections, two with bacterial meningitis and one with cellulitis of the cheek (cases 1, 2, 3, Table). The three infants were among five children younger than...
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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120290103024
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—The current interest in the literature1-4 in the spread of Haemophilus type b infections prompted us to add our recent experience with this problem that tends to confirm previous observations. Three infants, ages of 10 and 17 months, were admitted within an eight-day period with serious Haemophilus influenzae type b infections, two with bacterial meningitis and one with cellulitis of the cheek (cases 1, 2, 3, Table). The three infants were among five children younger than 2 years of age cared for during the day, as a group, in a small apartment by one grandmother babysitter. This striking coincidence of disease prompted an epidemiological investigation of immediate contacts including history, physical examination, nasopharyngeal cultures, and paired serum determinations for capsular antibody titers by radioimmunoassay technique. A total of 17 individuals were studied. The positive findings are shown in the accompanying Table. It was noted that one of the References 1. Tejani A, Bohdan D, Nangia BS, et al: Intrafamily spread of Haemophilus type b infection . Am J Dis Child 131:778-781, 1977. 2. Ginsburg CM, McCracken GH Jr, Rae S, et al: Haemophilus influenzae type b disease: Incidence in a day care center . JAMA 238:604-607, 1977.Crossref 3. Melish ME, Nelson AJ, Martin TE, et al: Epidemic spread of H influenzae type b (HIB) in a day care center . Pediatr Res 10:348, 1976. 4. Glode MP, Schiffer MS, Robbins JB, et al: An outbreak of Hemophilus influenzae type b meningitis in an enclosed hospital population . J Pediatr 88:36-40, 1976.Crossref 5. Norden CW, Michaels RH, Melish M: Serologic responses of children with meningitis due to Haemophilus influenzae type b . J Infect Dis 134:495-499, 1976.Crossref 6. Smith DH, Peter G, Ingram DL, Harding AL, et al: Responses of children immunized with the capsular polysaccharide of Hemophilus influenzae type b . Pediatrics 52:637-644, 1973.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1978

References