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Gynecomastia and Pseudoprecocious Puberty Following Diethylstilbestrol Exposure

Gynecomastia and Pseudoprecocious Puberty Following Diethylstilbestrol Exposure Abstract The purpose of this paper is to report the occurrence of gynecomastia in a 3-year-old boy and pseudoprecocious puberty in his 23-month-old sister following exposure to diethylstilbestrol (stilbestrol). Report of Cases A 38/12-year-old white boy was seen in the Yale Private Diagnostic Clinic on Oct. 22, 1956, because of bilateral breast enlargement present since January, 1956. There were no other complaints. Growth and development had otherwise been normal. The child was in the 50th percentile for height and 90th percentile for weight. As illustrated in Figure 1, the breasts were enlarged to a moderate degree. Freely moveable, circumscribed masses of glandular tissue about 2 cm. in diameter were palpable under the areolae. The nipples, areolae, and linea alba were deeply pigmented. A scanty amount of downy pubic hair was present. Axillary hair was absent. Neurologic and funduscopic examinations were negative. The testes were of normal size. No palpable testicular masses References 1. Prouty, M.: Gynecomastia with Pigmentation in a 4 Year Old Male Following Stilbestrol Exposure , Pediatrics 9:55, 1952. 2. Cook, C. D.; McArthur, J. W., and Berenberg, W.: Pseudoprecocious Puberty in Girls as a Result of Estrogen Ingestion , New England J. Med. 248:671, 1953.Crossref 3. Hesselvik, L.: Signs of Sexual Precocity in a Male Infant Due to Estrogenic Ointment , Acta pædiat . 41:177, 1952.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Gynecomastia and Pseudoprecocious Puberty Following Diethylstilbestrol Exposure

A.M.A. Journal of Diseases of Children , Volume 95 (6) – Jun 1, 1958

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1958.02060050641008
Publisher site
See Article on Publisher Site

Abstract

Abstract The purpose of this paper is to report the occurrence of gynecomastia in a 3-year-old boy and pseudoprecocious puberty in his 23-month-old sister following exposure to diethylstilbestrol (stilbestrol). Report of Cases A 38/12-year-old white boy was seen in the Yale Private Diagnostic Clinic on Oct. 22, 1956, because of bilateral breast enlargement present since January, 1956. There were no other complaints. Growth and development had otherwise been normal. The child was in the 50th percentile for height and 90th percentile for weight. As illustrated in Figure 1, the breasts were enlarged to a moderate degree. Freely moveable, circumscribed masses of glandular tissue about 2 cm. in diameter were palpable under the areolae. The nipples, areolae, and linea alba were deeply pigmented. A scanty amount of downy pubic hair was present. Axillary hair was absent. Neurologic and funduscopic examinations were negative. The testes were of normal size. No palpable testicular masses References 1. Prouty, M.: Gynecomastia with Pigmentation in a 4 Year Old Male Following Stilbestrol Exposure , Pediatrics 9:55, 1952. 2. Cook, C. D.; McArthur, J. W., and Berenberg, W.: Pseudoprecocious Puberty in Girls as a Result of Estrogen Ingestion , New England J. Med. 248:671, 1953.Crossref 3. Hesselvik, L.: Signs of Sexual Precocity in a Male Infant Due to Estrogenic Ointment , Acta pædiat . 41:177, 1952.Crossref

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1958

References