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Guanidine in Botulism-Reply

Guanidine in Botulism-Reply In Reply.— Guanidine is neither a cure for botulism nor has it helped all patients with botulism. That it has helped some patients with botulism is now documented in the world literature. In deciding whether or not to treat the patient with guanidine, the clinician might consider the following. Of the reported cases from this country and overseas, three times as many patients benefited from guanidine as those who did not.None of the botulism patients treated with guanidine suffered any irreversible side effects from the drug. The treatment time using guanidine is usually less than one month. As with any drug therapy, one must be alert to the possibility of serious side effects. If the drug is administered, one should obtain blood counts and tests of liver and renal function.Respiratory weakness remains the most resistant to reversal by guanidine. We have stressed this repeatedly in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Guanidine in Botulism-Reply

Cherington, Michael; Puggiari, Marcelo
JAMA , Volume 242 (3) – Jul 20, 1979
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Guanidine in Botulism-Reply

Abstract



In Reply.—
Guanidine is neither a cure for botulism nor has it helped all patients with botulism. That it has helped some patients with botulism is now documented in the world literature. In deciding whether or not to treat the patient with guanidine, the clinician might consider the following.
Of the reported cases from this country and overseas, three times as many patients benefited from guanidine as those who did not.None of the botulism patients treated with guanidine suffered...
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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1979.03300030013006
Publisher site
See Article on Publisher Site

Abstract

In Reply.— Guanidine is neither a cure for botulism nor has it helped all patients with botulism. That it has helped some patients with botulism is now documented in the world literature. In deciding whether or not to treat the patient with guanidine, the clinician might consider the following. Of the reported cases from this country and overseas, three times as many patients benefited from guanidine as those who did not.None of the botulism patients treated with guanidine suffered any irreversible side effects from the drug. The treatment time using guanidine is usually less than one month. As with any drug therapy, one must be alert to the possibility of serious side effects. If the drug is administered, one should obtain blood counts and tests of liver and renal function.Respiratory weakness remains the most resistant to reversal by guanidine. We have stressed this repeatedly in

Journal

JAMA – American Medical Association

Published: Jul 20, 1979

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