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Growth Hormone

Growth Hormone Abstract THE SUBJECT of this talk, I believe, would have been dear to the heart of Dr. Mitchell. He was interested in the growth and development of children, and it is on record that among the numerous lectures and talks which he gave, beyond the confines of this institution, are listed dissertations on endocrinologic diseases in children. About the time of his birth, in 1889, the understanding of the role of the pituitary in growth was beginning to emerge from the morass of confusion which had surrounded it until then. Pituitary gigantism was a well-known syndrome; Magendie, Cushing, and Hutchinson had written accurate clinical descriptions of the grotesque individuals suffering from excessive growth of the head, limbs, trunk, tongue, hands, and fingers. The first description appeared nearly 100 years ago, but the role of the pituitary gland in the production of gigantism and acromegaly lay undiscovered for a long time, because References 1. Raben, M.S.: Human Growth Hormone , Recent Progr Hormone Res 15:71, 1959. 2. Evans, N.M., and Long, J.A.: Effect of Anterior Lobe of Hypophysis Administered Intraperitoneally Upon Growth Maturity and Oestrus Cycles in Rats , Anat Rec 21:61, 1921. 3. Knobil, E., and Greep, R.O.: The Pituitary Hormones: The Physiology of Growth Hormone with Particular Reference to Its Action in the Rhesus Monkey and the "Species Specificity" Problem , Recent Progr Hormone Res 15:1, 1959. 4. Li, C.H.: Perspectives in the Biochemical Endocrinology of Adrenohypophyseal Hormones , Bull NY Acad Med 39:143, 1963. 5. Beck, J.C., et al: Metabolic Effects of Human and Monkey Growth Hormone in Man , Science 125:884, 1957.Crossref 6. Kaplan, S.A., and Shimizu, C.S.N.: Growth Hormone Effects on Cartilage Amino Acid Composition , Amer J Dis Child 105:576, 1963. 7. Houssay, B.A.: Hypophysis and Metabolism (Duncan Lecture) , New Eng J Med 214:961, 1936.Crossref 8. Trafford, J.A.P.; Lillicrap, D.A.; and Lessof, M.H.; Human Growth Hormone in Pituitary Infantilism , Lancet 1:1128, 1963.Crossref 9. Pearson, O.H., et al: Diabetogenic and Hypoglycemic Effects of Human Growth Hormone , Trans Ass Amer Physicians 73:217, 1960. 10. Beck, J.C., et al: Primate Growth Hormone Studies. 11. Deuben, R., and Meites, J.: In Vitro Stimulation of Growth Hormone Release from Rat Anterior Pituitary by Extract of Rat Hypothalamus , Fed Proc 22:571, 1963. 12. Warkany, J.; Monroe, B.B.; and Sutherland, B.S.: Intrauterine Growth Retardation , Amer J Dis Child 102:249, 1961. 13. Martin, M.M., and Wilkins, L.: Pituitary Dwarfism: Diagnosis and Treatment , J Clin Endocr 18:679, 1958.Crossref 14. Read, C.H., and Bryan, G.T.: The Immunological Assay of Human Growth Hormone , Recent Progr Hormone Res 16:187, 1960. 15. Glick, S.M., et al: Immunoassay of Human Growth Hormone in Plasma , Nature 199:784, 1963.Crossref 16. Greenwood, F.C.; Hunter, W.M.; and Marrian, V.J.: Growth Hormone Levels in Children and Adolescents , Brit Med J 1:25, 1964.Crossref 17. Roth, J., et al: Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone , Science 140:987, 1963.Crossref 18. Daughaday, W.H.; Salmon, W.D., Jr.; and Alexander, F.: Sulfation Factor Activity of Sera from Patients with Pituitary Disorders , J Clin Endocr 19:743, 1959.Crossref 19. Kogut, M.D.; Kaplan, S.A.; and Shimizu, C.S.N.: Growth Retardation: Use of Sulfation Factor as a Bioassay for Growth Hormone , Pediatrics 31:538, 1963. 20. Escamilla, R.F., et al: Long-term Effects of Human Growth Hormone (Li) in a Pituitary Dwarf , J Clin Endocr 21:721, 1961.Crossref 21. Shepard, T.H., et al: Human Growth Hormone: II. Further Study of Its Effects on Growth in Dwarfism , J Pediat 57:363, 1960.Crossref 22. Hutchings, J.J., et al: Metabolic Changes Produced by Human Growth Hormone (Li) in a Pituitary Dwarf , J Clin Endocr 19:759, 1959.Crossref 23. Prader, A., et al: Acquired Resistance to Human Growth Hormone Caused by Specific Antibodies , Lancet 2:378, 1964.Crossref 24. Parker, M.L.; Mariz, I.K.; and Daughaday, W.H.: Resistance to Human Growth Hormone in Pituitary Dwarfism: Clinical and Immunological Studies , J Clin Endocr 24: 997, 1964.Crossref 25. McGarry, E.E.; Beck, J.C.; and Gonda, E.: Human Growth Hormone-Like Activity of an Ovine Prolactin Preparation in Hypopituitary Patients, Program of the 45th Meeting of the Endocrine Society, Atlantic City, NJ, June 13-15, 1963, p 8. 26. Nadler, H.L.; Neumann, L.L.; and Gershberg, H.: Hypoglycemia, Growth Retardation and Probable Isolated Growth Hormone Deficiency in a 1 Year-Old Child , J Pediat 69:977, 1963.Crossref 27. Mahow, W.A., et al: Effect of Human Growth Hormone on Hypoglycemia States , New Eng J Med 267:1179, 1962.Crossref 28. Kaplan, S.A.: Growth Disorders in Children and Adolescents , Springfield: Charles C Thomas, Publisher, 1964. 29. Collipp, P.J., et al: C-14-Acetyl Bovine Growth Hormone , J Biol Chem 240:143, 1965. 30. Collipp, P.J., et al: Protein Bound Human Growth Hormone , Metabolism 13:532, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1965.02090030246002
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Abstract

Abstract THE SUBJECT of this talk, I believe, would have been dear to the heart of Dr. Mitchell. He was interested in the growth and development of children, and it is on record that among the numerous lectures and talks which he gave, beyond the confines of this institution, are listed dissertations on endocrinologic diseases in children. About the time of his birth, in 1889, the understanding of the role of the pituitary in growth was beginning to emerge from the morass of confusion which had surrounded it until then. Pituitary gigantism was a well-known syndrome; Magendie, Cushing, and Hutchinson had written accurate clinical descriptions of the grotesque individuals suffering from excessive growth of the head, limbs, trunk, tongue, hands, and fingers. The first description appeared nearly 100 years ago, but the role of the pituitary gland in the production of gigantism and acromegaly lay undiscovered for a long time, because References 1. Raben, M.S.: Human Growth Hormone , Recent Progr Hormone Res 15:71, 1959. 2. Evans, N.M., and Long, J.A.: Effect of Anterior Lobe of Hypophysis Administered Intraperitoneally Upon Growth Maturity and Oestrus Cycles in Rats , Anat Rec 21:61, 1921. 3. Knobil, E., and Greep, R.O.: The Pituitary Hormones: The Physiology of Growth Hormone with Particular Reference to Its Action in the Rhesus Monkey and the "Species Specificity" Problem , Recent Progr Hormone Res 15:1, 1959. 4. Li, C.H.: Perspectives in the Biochemical Endocrinology of Adrenohypophyseal Hormones , Bull NY Acad Med 39:143, 1963. 5. Beck, J.C., et al: Metabolic Effects of Human and Monkey Growth Hormone in Man , Science 125:884, 1957.Crossref 6. Kaplan, S.A., and Shimizu, C.S.N.: Growth Hormone Effects on Cartilage Amino Acid Composition , Amer J Dis Child 105:576, 1963. 7. Houssay, B.A.: Hypophysis and Metabolism (Duncan Lecture) , New Eng J Med 214:961, 1936.Crossref 8. Trafford, J.A.P.; Lillicrap, D.A.; and Lessof, M.H.; Human Growth Hormone in Pituitary Infantilism , Lancet 1:1128, 1963.Crossref 9. Pearson, O.H., et al: Diabetogenic and Hypoglycemic Effects of Human Growth Hormone , Trans Ass Amer Physicians 73:217, 1960. 10. Beck, J.C., et al: Primate Growth Hormone Studies. 11. Deuben, R., and Meites, J.: In Vitro Stimulation of Growth Hormone Release from Rat Anterior Pituitary by Extract of Rat Hypothalamus , Fed Proc 22:571, 1963. 12. Warkany, J.; Monroe, B.B.; and Sutherland, B.S.: Intrauterine Growth Retardation , Amer J Dis Child 102:249, 1961. 13. Martin, M.M., and Wilkins, L.: Pituitary Dwarfism: Diagnosis and Treatment , J Clin Endocr 18:679, 1958.Crossref 14. Read, C.H., and Bryan, G.T.: The Immunological Assay of Human Growth Hormone , Recent Progr Hormone Res 16:187, 1960. 15. Glick, S.M., et al: Immunoassay of Human Growth Hormone in Plasma , Nature 199:784, 1963.Crossref 16. Greenwood, F.C.; Hunter, W.M.; and Marrian, V.J.: Growth Hormone Levels in Children and Adolescents , Brit Med J 1:25, 1964.Crossref 17. Roth, J., et al: Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone , Science 140:987, 1963.Crossref 18. Daughaday, W.H.; Salmon, W.D., Jr.; and Alexander, F.: Sulfation Factor Activity of Sera from Patients with Pituitary Disorders , J Clin Endocr 19:743, 1959.Crossref 19. Kogut, M.D.; Kaplan, S.A.; and Shimizu, C.S.N.: Growth Retardation: Use of Sulfation Factor as a Bioassay for Growth Hormone , Pediatrics 31:538, 1963. 20. Escamilla, R.F., et al: Long-term Effects of Human Growth Hormone (Li) in a Pituitary Dwarf , J Clin Endocr 21:721, 1961.Crossref 21. Shepard, T.H., et al: Human Growth Hormone: II. Further Study of Its Effects on Growth in Dwarfism , J Pediat 57:363, 1960.Crossref 22. Hutchings, J.J., et al: Metabolic Changes Produced by Human Growth Hormone (Li) in a Pituitary Dwarf , J Clin Endocr 19:759, 1959.Crossref 23. Prader, A., et al: Acquired Resistance to Human Growth Hormone Caused by Specific Antibodies , Lancet 2:378, 1964.Crossref 24. Parker, M.L.; Mariz, I.K.; and Daughaday, W.H.: Resistance to Human Growth Hormone in Pituitary Dwarfism: Clinical and Immunological Studies , J Clin Endocr 24: 997, 1964.Crossref 25. McGarry, E.E.; Beck, J.C.; and Gonda, E.: Human Growth Hormone-Like Activity of an Ovine Prolactin Preparation in Hypopituitary Patients, Program of the 45th Meeting of the Endocrine Society, Atlantic City, NJ, June 13-15, 1963, p 8. 26. Nadler, H.L.; Neumann, L.L.; and Gershberg, H.: Hypoglycemia, Growth Retardation and Probable Isolated Growth Hormone Deficiency in a 1 Year-Old Child , J Pediat 69:977, 1963.Crossref 27. Mahow, W.A., et al: Effect of Human Growth Hormone on Hypoglycemia States , New Eng J Med 267:1179, 1962.Crossref 28. Kaplan, S.A.: Growth Disorders in Children and Adolescents , Springfield: Charles C Thomas, Publisher, 1964. 29. Collipp, P.J., et al: C-14-Acetyl Bovine Growth Hormone , J Biol Chem 240:143, 1965. 30. Collipp, P.J., et al: Protein Bound Human Growth Hormone , Metabolism 13:532, 1964.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1965

References