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Griseofulvin in the Treatment of Some Deep Mycoses

Griseofulvin in the Treatment of Some Deep Mycoses Abstract Soon after the first reports on griseofulvin therapy of skin mycoses we began to use this new drug in Mexico. Our results on dermatophytoses23 are similar to those of other investigators and they are not the subject of this paper. The action of griseofulvin on deep mycoses was not or scarcely considered in the early studies, because in in vitro observations, Sporotrichum schenckii and other fungi were found insensitive.3 As deep mycoses are frequent in Mexico we decided, however, to study their response to this therapy. This paper is a preliminary report on this matter. Griseofulvin, as it is well known, was first isolated by Oxford, Raistrick, and Simonart25 in 1939 as a metabolic product from Penicillium griseofulvum. In 1946, Brian et al.6 described a fungistatic "curlingfactor" obtained from Penicillium janczewskii, and its identity with griseofulvin was established by Grove and McGowan13 the following year. References 1. Supplied by Dr. J. W. Wilson, Los Angeles, Calif.; Glaxo Laboratories Ltd., Greenford, England, and Schering Corporation, Bloomfield, N.J. 2. Arnold, H. L., Jr., and Austin, E. R.: Diasone Therapy of Actinomycosis of the Jaw: Report of a Case , J.A.M.A. 138:955, 1948.Crossref 3. Beirana, L., and Novales, J.: Tiña universal y granulomatosa por trichophyton tonsurans: Estudio de un caso y discusión patogénica , Dermatología rev. Mex. 3:4, 1959. 4. Blank, H., and Roth, F. J., Jr.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A.M.A. Arch. Dermat. 79:259, 1959.Crossref 5. Bonilla, E.: Treatment of Chromoblastomycosis with Calciferol: Report of 3 Cases , A.M.A. Arch. Dermat. & Syph. 70:665, 1954. 6. Bopp, C.: Tratamento da cromoblastomicose pelo calciferol: Evolucao clínica e controle histo-Patológico, Of. Gráf. da Livraria do Globo S.A. Porto Alegre, Brasil, 1957. 7. Brian, P. W.; Curtis, P. J., and Hemming, H. G.: A Substance Causing Abnormal Development of Fungal Hyphae Produced by Penicillium Janczewskii Zal: I. Biological Assay, Production and Isolation of "Curling Factor ," Tr. Brit. Mycol. Soc. 29:173, 1946. 8. Brian, P. W.: Antibiotics as Systemic Fungicides and Bactericides , Ann. Appl. Biol. 39:434, 1952. 9. Castro-Palomino, J., and Armenteros, J. A.: Contribución al estudio de la cromoblastomicosis en Cuba , Rev. med. y cirug, Habana 46:217, 1941. 10. Flood, J. M., in Round-Table Discussion on Griseofulvin, at Convention of the American Dermatological Association, Inc., Atlantic City, N.J., (June 4) 1959 . 11. Garcia, P. M.: Sulfonas en el tratamiento del micetoma: Estudio de un caso , Prensa méd. Mex. 15:262, 1950. 12. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature, London 182:476, 1958. 13. Gonzalez-Ochoa, A.; Shiels, J., and Vazquez, P.: Acción de la 4-4'diamino-difenilsulfona frente a nocardia brasiliensis: Estudio in vitro en la infección experimental y en la clínica , Gac. méd. méxico 82:345, 1952. 14. Grove, J. F., and McGowan, J. C.: Identity of Griseofulvin and "Curling-Factor ," Nature, London 160:574, 1947. 15. Latapi, F.: Cited by Arnold.1 16. Latapi, F.: Esporotricosis facial infantil: Nota clínica, estudio de un caso , Prensa méd. mex. 15:259, 1950. 17. Latapi, F.: Cited by González-Ochoa.12 18. Latapi, F.; Lavalle, A. P., and Arenas, A.: Isoniazida en nocardiosis: Nota preliminar , Acta Society of Mexican Dermatology ( (Feb. 12) ) 1953. 19. Latapi, F., and Lavalle, A. P.: Emploi des sulfones et de l'isoniazide dans le traitement des mycétomes , Minutes of 8th Congress Internationale Botanique, Paris, 1954 , p. 44. 20. Latapi, F.: Micetoma: Análisis de 100 casos estudiados en la Ciudad de México , Minutes of the 3d Congress of Iberero-Latin American Dermatologists, México, 1959 , p. 203. 21. Latapi, F.: Griseofulvina: Un nuevo antimicótico por vía oral , Sem. méd. Méx. 20:113, 1959. 22. Latapi, F.: Griseofulvina: Presentación preliminar de resultados en un caso de tricofitosis universal y en un caso de micetoma del pie por n. brasiliensis , Acta Session of Clinical Society of Mexican Dermatology, (Feb. 19) 1959 . 23. Latapi, F.; Lavalle, P.; Novales, J., and Ortiz, Y.: Griseofulvina en micosis cutáneas profundas: Nota preliminar sobre resultados terapéuticos en un caso de micetoma por n. brasiliensis y en uno de esporotricosis por S. schenckii , Dermatología rev. Mex. 3:34, 1959. 24. Latapi, F., and Ortiz, Y.: Griseofulvina en micosis cutáneas superficiales y profundas: Observaciones clínicas y resultados terapéuticos en 48 casos, To be published. 25. Lavalle, P.: Griseofulvina en un caso de micetoma , Acta Session of Clínical. Society of Mexican Dermatology (Feb. 19) 1959 . 26. Oxford, A. E.; Raistrick, H., and Simonart, P.: Griseofulvin, C17H17O6Cl, a Metabolic Product of Penicillium Griseofulvum Dierckx , Biochem. J. 33:240, 1939. 27. Pardo-Castello, V.; Trespalacios, F.; Fariñas, P., and Baquero, G. F.: El tratamiento de las micosis superficiales de lapiel con griseofulvin , Bol. Soc. cubana dermat. y sif. 16:1, 1959. 28. Riehl, G.: Griseofulvin: ein peroral wirkendes Antimykoticum , Hautarzt 10:136, 1959. 29. Rodriguez, O.: Cromoblastomicosis: Tratamiento con calciferol , Minutes of the 3d Congress Iberian and Latin American Dermatologists México, 1959 , p. 182. 30. Williams, D. I.; Marten, R. H., and Sarkany, I.: Oral Treatment of Ringworm with Griseofulvin , Lancet 2:1212, 1958. 31. Wilson, J. W.: Possible Approaches to the Therapy of Fungus Diseases , in Therapy of Fungus Diseases: An International Symposium , edited by T. H. Sternberg and V. D. Newcomer, Boston, Little, Brown and Company, 1955, p. 25. 32. Wilson, J. W.: Personal communication with the author (Dec.) 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Griseofulvin in the Treatment of Some Deep Mycoses

A.M.A. Archives of Dermatology , Volume 81 (5) – May 1, 1960

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730050197036
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Abstract

Abstract Soon after the first reports on griseofulvin therapy of skin mycoses we began to use this new drug in Mexico. Our results on dermatophytoses23 are similar to those of other investigators and they are not the subject of this paper. The action of griseofulvin on deep mycoses was not or scarcely considered in the early studies, because in in vitro observations, Sporotrichum schenckii and other fungi were found insensitive.3 As deep mycoses are frequent in Mexico we decided, however, to study their response to this therapy. This paper is a preliminary report on this matter. Griseofulvin, as it is well known, was first isolated by Oxford, Raistrick, and Simonart25 in 1939 as a metabolic product from Penicillium griseofulvum. In 1946, Brian et al.6 described a fungistatic "curlingfactor" obtained from Penicillium janczewskii, and its identity with griseofulvin was established by Grove and McGowan13 the following year. References 1. Supplied by Dr. J. W. Wilson, Los Angeles, Calif.; Glaxo Laboratories Ltd., Greenford, England, and Schering Corporation, Bloomfield, N.J. 2. Arnold, H. L., Jr., and Austin, E. R.: Diasone Therapy of Actinomycosis of the Jaw: Report of a Case , J.A.M.A. 138:955, 1948.Crossref 3. Beirana, L., and Novales, J.: Tiña universal y granulomatosa por trichophyton tonsurans: Estudio de un caso y discusión patogénica , Dermatología rev. Mex. 3:4, 1959. 4. Blank, H., and Roth, F. J., Jr.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A.M.A. Arch. Dermat. 79:259, 1959.Crossref 5. Bonilla, E.: Treatment of Chromoblastomycosis with Calciferol: Report of 3 Cases , A.M.A. Arch. Dermat. & Syph. 70:665, 1954. 6. Bopp, C.: Tratamento da cromoblastomicose pelo calciferol: Evolucao clínica e controle histo-Patológico, Of. Gráf. da Livraria do Globo S.A. Porto Alegre, Brasil, 1957. 7. Brian, P. W.; Curtis, P. J., and Hemming, H. G.: A Substance Causing Abnormal Development of Fungal Hyphae Produced by Penicillium Janczewskii Zal: I. Biological Assay, Production and Isolation of "Curling Factor ," Tr. Brit. Mycol. Soc. 29:173, 1946. 8. Brian, P. W.: Antibiotics as Systemic Fungicides and Bactericides , Ann. Appl. Biol. 39:434, 1952. 9. Castro-Palomino, J., and Armenteros, J. A.: Contribución al estudio de la cromoblastomicosis en Cuba , Rev. med. y cirug, Habana 46:217, 1941. 10. Flood, J. M., in Round-Table Discussion on Griseofulvin, at Convention of the American Dermatological Association, Inc., Atlantic City, N.J., (June 4) 1959 . 11. Garcia, P. M.: Sulfonas en el tratamiento del micetoma: Estudio de un caso , Prensa méd. Mex. 15:262, 1950. 12. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature, London 182:476, 1958. 13. Gonzalez-Ochoa, A.; Shiels, J., and Vazquez, P.: Acción de la 4-4'diamino-difenilsulfona frente a nocardia brasiliensis: Estudio in vitro en la infección experimental y en la clínica , Gac. méd. méxico 82:345, 1952. 14. Grove, J. F., and McGowan, J. C.: Identity of Griseofulvin and "Curling-Factor ," Nature, London 160:574, 1947. 15. Latapi, F.: Cited by Arnold.1 16. Latapi, F.: Esporotricosis facial infantil: Nota clínica, estudio de un caso , Prensa méd. mex. 15:259, 1950. 17. Latapi, F.: Cited by González-Ochoa.12 18. Latapi, F.; Lavalle, A. P., and Arenas, A.: Isoniazida en nocardiosis: Nota preliminar , Acta Society of Mexican Dermatology ( (Feb. 12) ) 1953. 19. Latapi, F., and Lavalle, A. P.: Emploi des sulfones et de l'isoniazide dans le traitement des mycétomes , Minutes of 8th Congress Internationale Botanique, Paris, 1954 , p. 44. 20. Latapi, F.: Micetoma: Análisis de 100 casos estudiados en la Ciudad de México , Minutes of the 3d Congress of Iberero-Latin American Dermatologists, México, 1959 , p. 203. 21. Latapi, F.: Griseofulvina: Un nuevo antimicótico por vía oral , Sem. méd. Méx. 20:113, 1959. 22. Latapi, F.: Griseofulvina: Presentación preliminar de resultados en un caso de tricofitosis universal y en un caso de micetoma del pie por n. brasiliensis , Acta Session of Clinical Society of Mexican Dermatology, (Feb. 19) 1959 . 23. Latapi, F.; Lavalle, P.; Novales, J., and Ortiz, Y.: Griseofulvina en micosis cutáneas profundas: Nota preliminar sobre resultados terapéuticos en un caso de micetoma por n. brasiliensis y en uno de esporotricosis por S. schenckii , Dermatología rev. Mex. 3:34, 1959. 24. Latapi, F., and Ortiz, Y.: Griseofulvina en micosis cutáneas superficiales y profundas: Observaciones clínicas y resultados terapéuticos en 48 casos, To be published. 25. Lavalle, P.: Griseofulvina en un caso de micetoma , Acta Session of Clínical. Society of Mexican Dermatology (Feb. 19) 1959 . 26. Oxford, A. E.; Raistrick, H., and Simonart, P.: Griseofulvin, C17H17O6Cl, a Metabolic Product of Penicillium Griseofulvum Dierckx , Biochem. J. 33:240, 1939. 27. Pardo-Castello, V.; Trespalacios, F.; Fariñas, P., and Baquero, G. F.: El tratamiento de las micosis superficiales de lapiel con griseofulvin , Bol. Soc. cubana dermat. y sif. 16:1, 1959. 28. Riehl, G.: Griseofulvin: ein peroral wirkendes Antimykoticum , Hautarzt 10:136, 1959. 29. Rodriguez, O.: Cromoblastomicosis: Tratamiento con calciferol , Minutes of the 3d Congress Iberian and Latin American Dermatologists México, 1959 , p. 182. 30. Williams, D. I.; Marten, R. H., and Sarkany, I.: Oral Treatment of Ringworm with Griseofulvin , Lancet 2:1212, 1958. 31. Wilson, J. W.: Possible Approaches to the Therapy of Fungus Diseases , in Therapy of Fungus Diseases: An International Symposium , edited by T. H. Sternberg and V. D. Newcomer, Boston, Little, Brown and Company, 1955, p. 25. 32. Wilson, J. W.: Personal communication with the author (Dec.) 1958.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: May 1, 1960

References