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Graves' Disease in the Male: A Review of 241 Cases Treated With an Individually Calculated Dose of Sodium Iodide I 131

Graves' Disease in the Male: A Review of 241 Cases Treated With an Individually Calculated Dose... Abstract This report encompasses a 20-year study of 241 male patients with Graves' disease. All patients received a therapeutic dose of sodium iodide I 131 calculated from the 24-hour thyroid uptake, the effective half-life of the retained 131I tracer dose, and the gland weight. The gland weight was determined by an empirical weight formula from the thyroid scintigram. Forty-five percent of the total patient group and 74% of the Negro patients required multiple doses. Patients who required multiple doses had more severe laboratory abnormalities and lost more weight. These patients also became hypothyroid later and ultimately had a higher incidence of hypothyroidism than patients who received single doses. The mean incidence of hypothyroidism for the entire series was 27.8%. The actual number of millicuries of 131I required to deliver the therapeutic dose had little or no relation to the ultimate therapeutic effect. References 1. Survey of the Use of Radionuclides in Medicine . Rockville, Md, Public Health Service, (Environmental Health Service, Bureau of Radiological Health) Technical Report BRH/DMRE, 1970. 2. Dunn JT, Chapman EM: Rising incidence of hypothyroidism after radioactive-iodine therapy in thyrotoxicosis. New Eng J Med 271:1037-1042, 1964.Crossref 3. Bronsky D, Kiamko RT, Waldstein SS: Posttherapeutic myxedema. Arch Intern Med 121:113-117, 1968.Crossref 4. Stanbury JB, DeGroot LJ: Problem of hypothyroidism after 131I therapy of hyperthyroidism. New Eng J Med 271:195-196, 1964.Crossref 5. Greig WR: The treatment of thyrotoxicosis with radioactive iodine. Scot Med J 11:307-314, 1966. 6. Burke G, Silverstein GE: Hypothyroidism after treatment with sodium iodide I131. JAMA 210:1051-1058,1969.Crossref 7. Hagen GA, Ouellette, RP, Chapman EM: Comparison of high and low dosage levels of 131I in the treatment of thyrotoxicosis. New Eng J Med 277:559-562, 1967.Crossref 8. Smith RN, Wilson GM: Clinical trial of different doses of 131I in treatment of thyrotoxicosis. Brit Med J 1:129-132, 1967.Crossref 9. Goodwin WE, Cassen B, Bauer FK: Thyroid gland weight determination from thyroid scintigrams with postmortem verification. Radiology 61:88-92, 1953.Crossref 10. Marinelli LD, Quimby FH, Hine GJ: Dosage determination with radioactive isotopes: II. Practical considerations in therapy and protection. Amer J Roentgen 59:260-281, 1948. 11. Bauer FK, Blahd WH: Treatment of hyperthyroidism with individually calculated doses of 131I. Arch Intern Med 99:194-201, 1957.Crossref 12. Skillman TG, Mazzaferri EL, Gwinup G: Random dosage of 131I in the treatment of hyperthyroidism: Results of a prospective study. Amer J Med Sci 257:382-387, 1969.Crossref 13. Blomfield GW, Eckert H, Fisher M, et al: Treatment of thyrotoxicosis with 131I. Brit Med J 1:63-74, 1959.Crossref 14. Green M, Wilson GM: Thyrotoxicosis treated by surgery or iodine-131: With special reference to development of hypothyroidism. Brit Med J 1:1005-1010, 1964.Crossref 15. Nofal MM, Beierwaltes WH, Patno ME: Treatment of hyperthyroidism with sodium iodide I 131. JAMA 197:605-610, 1966.Crossref 16. Bartels EC, Irie M: Thyroid function in patients with progressive exophthalmos: Study of 117 cases requiring orbital decompression , in Pitt-Rivers R (ed): Advances in Thyroid Research . Oxford, England, Pergamon Press, 1961, pp 163-170. 17. Blomfield GW, Jones JC, Macgregor AG, et al: Treatment of thyrotoxicosis with radioactive iodine: Review of 140 cases. Brit Med J 2:1223-1229, 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Graves' Disease in the Male: A Review of 241 Cases Treated With an Individually Calculated Dose of Sodium Iodide I 131

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1972.00320010037002
Publisher site
See Article on Publisher Site

Abstract

Abstract This report encompasses a 20-year study of 241 male patients with Graves' disease. All patients received a therapeutic dose of sodium iodide I 131 calculated from the 24-hour thyroid uptake, the effective half-life of the retained 131I tracer dose, and the gland weight. The gland weight was determined by an empirical weight formula from the thyroid scintigram. Forty-five percent of the total patient group and 74% of the Negro patients required multiple doses. Patients who required multiple doses had more severe laboratory abnormalities and lost more weight. These patients also became hypothyroid later and ultimately had a higher incidence of hypothyroidism than patients who received single doses. The mean incidence of hypothyroidism for the entire series was 27.8%. The actual number of millicuries of 131I required to deliver the therapeutic dose had little or no relation to the ultimate therapeutic effect. References 1. Survey of the Use of Radionuclides in Medicine . Rockville, Md, Public Health Service, (Environmental Health Service, Bureau of Radiological Health) Technical Report BRH/DMRE, 1970. 2. Dunn JT, Chapman EM: Rising incidence of hypothyroidism after radioactive-iodine therapy in thyrotoxicosis. New Eng J Med 271:1037-1042, 1964.Crossref 3. Bronsky D, Kiamko RT, Waldstein SS: Posttherapeutic myxedema. Arch Intern Med 121:113-117, 1968.Crossref 4. Stanbury JB, DeGroot LJ: Problem of hypothyroidism after 131I therapy of hyperthyroidism. New Eng J Med 271:195-196, 1964.Crossref 5. Greig WR: The treatment of thyrotoxicosis with radioactive iodine. Scot Med J 11:307-314, 1966. 6. Burke G, Silverstein GE: Hypothyroidism after treatment with sodium iodide I131. JAMA 210:1051-1058,1969.Crossref 7. Hagen GA, Ouellette, RP, Chapman EM: Comparison of high and low dosage levels of 131I in the treatment of thyrotoxicosis. New Eng J Med 277:559-562, 1967.Crossref 8. Smith RN, Wilson GM: Clinical trial of different doses of 131I in treatment of thyrotoxicosis. Brit Med J 1:129-132, 1967.Crossref 9. Goodwin WE, Cassen B, Bauer FK: Thyroid gland weight determination from thyroid scintigrams with postmortem verification. Radiology 61:88-92, 1953.Crossref 10. Marinelli LD, Quimby FH, Hine GJ: Dosage determination with radioactive isotopes: II. Practical considerations in therapy and protection. Amer J Roentgen 59:260-281, 1948. 11. Bauer FK, Blahd WH: Treatment of hyperthyroidism with individually calculated doses of 131I. Arch Intern Med 99:194-201, 1957.Crossref 12. Skillman TG, Mazzaferri EL, Gwinup G: Random dosage of 131I in the treatment of hyperthyroidism: Results of a prospective study. Amer J Med Sci 257:382-387, 1969.Crossref 13. Blomfield GW, Eckert H, Fisher M, et al: Treatment of thyrotoxicosis with 131I. Brit Med J 1:63-74, 1959.Crossref 14. Green M, Wilson GM: Thyrotoxicosis treated by surgery or iodine-131: With special reference to development of hypothyroidism. Brit Med J 1:1005-1010, 1964.Crossref 15. Nofal MM, Beierwaltes WH, Patno ME: Treatment of hyperthyroidism with sodium iodide I 131. JAMA 197:605-610, 1966.Crossref 16. Bartels EC, Irie M: Thyroid function in patients with progressive exophthalmos: Study of 117 cases requiring orbital decompression , in Pitt-Rivers R (ed): Advances in Thyroid Research . Oxford, England, Pergamon Press, 1961, pp 163-170. 17. Blomfield GW, Jones JC, Macgregor AG, et al: Treatment of thyrotoxicosis with radioactive iodine: Review of 140 cases. Brit Med J 2:1223-1229, 1955.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1972

References