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Granuloma Annulare Treated With Chlorambucil: An 18-Month Follow-up

Granuloma Annulare Treated With Chlorambucil: An 18-Month Follow-up Abstract To the Editor.— Granuloma annulare (GA) is a disease of unknown etiology. Recent studies have implicated a delayed hypersensitivity reaction in the pathogenesis of the disease.1,2 Accordingly, alkylating agents (especially chlorambucil), which interfere with T-lymphocyte activity, have been used successfully in the treatment of GA.3-5 However, in the patients treated there has usually been no longterm follow-up examination. We describe herein a patient with disseminated GA who was treated with chlorambucil and whose condition was re-evaluated for 18 months. Report of a Case.—A 60-year-old woman was initially seen in January 1980 with a one-year history of a slightly itchy eruption over the dorsal surfaces of the hands and feet, over the forearms, and on the posterior part of the neck. The lesions on the hands had been treated with intradermal corticosteroid injections. On examination there were numerous, discrete, and confluent, slightly erythematous, shiny papules and annular plaques with References 1. Umbert P, Winkelmann RK: Granuloma annulare: Direct immunofluorescence study . Br J Dermatol 1976;95:487-492.Crossref 2. Umbert P, Winkelmann RK: Histologic, ultrastructural, and histochemical studies of granuloma annulare . Arch Dermatol 1977;113:1681-1686.Crossref 3. Kossard S, Winkelmann RK: Response of generalized granuloma annulare to alkylating agents . Arch Dermatol 1978;114:216-220.Crossref 4. Rudolph RI: Disseminated granuloma annulare treated with low-dose chlorambucil . Arch Dermatol 1979;115:1212-1213.Crossref 5. Kossard S, Winkelmann RK: Low-dose chlorambucil in the treatment of generalized granuloma annulare . Dermatologica 1979;158:443-450.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Granuloma Annulare Treated With Chlorambucil: An 18-Month Follow-up

Archives of Dermatology , Volume 119 (6) – Jun 1, 1983

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650300005004
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Granuloma annulare (GA) is a disease of unknown etiology. Recent studies have implicated a delayed hypersensitivity reaction in the pathogenesis of the disease.1,2 Accordingly, alkylating agents (especially chlorambucil), which interfere with T-lymphocyte activity, have been used successfully in the treatment of GA.3-5 However, in the patients treated there has usually been no longterm follow-up examination. We describe herein a patient with disseminated GA who was treated with chlorambucil and whose condition was re-evaluated for 18 months. Report of a Case.—A 60-year-old woman was initially seen in January 1980 with a one-year history of a slightly itchy eruption over the dorsal surfaces of the hands and feet, over the forearms, and on the posterior part of the neck. The lesions on the hands had been treated with intradermal corticosteroid injections. On examination there were numerous, discrete, and confluent, slightly erythematous, shiny papules and annular plaques with References 1. Umbert P, Winkelmann RK: Granuloma annulare: Direct immunofluorescence study . Br J Dermatol 1976;95:487-492.Crossref 2. Umbert P, Winkelmann RK: Histologic, ultrastructural, and histochemical studies of granuloma annulare . Arch Dermatol 1977;113:1681-1686.Crossref 3. Kossard S, Winkelmann RK: Response of generalized granuloma annulare to alkylating agents . Arch Dermatol 1978;114:216-220.Crossref 4. Rudolph RI: Disseminated granuloma annulare treated with low-dose chlorambucil . Arch Dermatol 1979;115:1212-1213.Crossref 5. Kossard S, Winkelmann RK: Low-dose chlorambucil in the treatment of generalized granuloma annulare . Dermatologica 1979;158:443-450.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1983

References