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Granulocyte Colony-Stimulating Factor for Neutropenia in Neonatal Sepsis-Reply

Granulocyte Colony-Stimulating Factor for Neutropenia in Neonatal Sepsis-Reply Abstract We appreciate Nankervis and Seguin's patient report of another neonate who apparently benefited from rhG-CSF administration during bacterial sepsis. They aptly note the main differences in the two cases, namely route and duration of cytokine administration and neutrophil count response. Each patient had a very rapid rise in the neutrophil count, likely due to the release of mature neutrophils from the bone marrow neutrophil storage pool.1 The differences in the duration of neutrophilia in the two cases may have reflected the subcutaneous vs intravenous routes of administration (prolonged systemic uptake from a subcutaneous drug depot in our case), the total number of doses given, or both. We disagree, however, that the single granulocyte transfusion that our patient received altered the degree of neutrophilia or natural outcome of his rhG-CSF response, since transfused granulocytes have such a short life span.2,3 While both patients received aggressive supportive care that included References 1. Cairo MS, Plunkett JM, Mauss D, van de Ven C. Seven-day administration of recombinant human granulocyte colony-stimulating factor to newborn rats: modulation of neonatal neutrophilia, myelopoiesis, and group B streptococcus sepsis . Blood . 1990;76:1788-1794. 2. Athens JW, Raab SO, Haab OP, et al. Leukokinetic studies, III: the distribution of granulocytes in the blood of normal subjects . J Clin Invest . 1961;40: 159-164.Crossref 3. Boggs DR. Transfusion of neutrophils as prevention or treatment of infection in patients with neutropenia . N Engl J Med . 1974;290:1055-1062.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pediatrics & Adolescent Medicine American Medical Association

Granulocyte Colony-Stimulating Factor for Neutropenia in Neonatal Sepsis-Reply

Granulocyte Colony-Stimulating Factor for Neutropenia in Neonatal Sepsis-Reply

Abstract

Abstract We appreciate Nankervis and Seguin's patient report of another neonate who apparently benefited from rhG-CSF administration during bacterial sepsis. They aptly note the main differences in the two cases, namely route and duration of cytokine administration and neutrophil count response. Each patient had a very rapid rise in the neutrophil count, likely due to the release of mature neutrophils from the bone marrow neutrophil storage pool.1 The differences in the duration of...
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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
1072-4710
eISSN
1538-3628
DOI
10.1001/archpedi.1995.02170140100022
Publisher site
See Article on Publisher Site

Abstract

Abstract We appreciate Nankervis and Seguin's patient report of another neonate who apparently benefited from rhG-CSF administration during bacterial sepsis. They aptly note the main differences in the two cases, namely route and duration of cytokine administration and neutrophil count response. Each patient had a very rapid rise in the neutrophil count, likely due to the release of mature neutrophils from the bone marrow neutrophil storage pool.1 The differences in the duration of neutrophilia in the two cases may have reflected the subcutaneous vs intravenous routes of administration (prolonged systemic uptake from a subcutaneous drug depot in our case), the total number of doses given, or both. We disagree, however, that the single granulocyte transfusion that our patient received altered the degree of neutrophilia or natural outcome of his rhG-CSF response, since transfused granulocytes have such a short life span.2,3 While both patients received aggressive supportive care that included References 1. Cairo MS, Plunkett JM, Mauss D, van de Ven C. Seven-day administration of recombinant human granulocyte colony-stimulating factor to newborn rats: modulation of neonatal neutrophilia, myelopoiesis, and group B streptococcus sepsis . Blood . 1990;76:1788-1794. 2. Athens JW, Raab SO, Haab OP, et al. Leukokinetic studies, III: the distribution of granulocytes in the blood of normal subjects . J Clin Invest . 1961;40: 159-164.Crossref 3. Boggs DR. Transfusion of neutrophils as prevention or treatment of infection in patients with neutropenia . N Engl J Med . 1974;290:1055-1062.Crossref

Journal

Archives of Pediatrics & Adolescent MedicineAmerican Medical Association

Published: Feb 1, 1995

References