Abstract GRANULAR cell myoblastoma and rhabdomyoma are the two tumor types, both rare, arising from striated muscle cells. The myoblastomas were described originally as "Myoblastenmyome" by Abrikossoff1 in 1926. At that time he regarded them as neoplasms due to faulty excessive regeneration subsequent to injury of striated muscle. In 1931, realizing that some of these tumors arose in areas devoid of striated muscle, he postulated2 their origin from primitive myoblasts representing embryonal rests. He classified myoblastomas into four histopathologic types: (1) those consisting of granular myoblastic cells without the presence of striation, (2) the same type with the addition of occasional faint striations, (3) hypertrophic forms consisting of large multinucleated cells and (4) malignant myoblastic myomas consisting of pleomorphic cells, some areas showing differentiation and striations and others frankly sarcomatous in appearance. On gross examination, myoblastomas are tumors varying in diameter from 0.5 to 2 cm., although they occasionally References 1. Abrikossoff, A.: Ueber Myome, ausgehend von der quergestreiften willkürlichen Muskulature , Virchows Arch. f. path. Anat. 260:215, 1926.Crossref 2. Abrikossoff, A.: Weitere Untersuchungen ueber Myoblastenmyome , Virchows Arch. f. path. Anat. 280:723, 1931.Crossref 3. Crane, A. R., and Tremblay, R. G.: Myoblastoma , Am. J. Path. 21:357 ( (March) ) 1945. 4. Geschickter, C. F.: Tumors of Muscle , Am. J. Cancer 22:378 ( (Oct.) ) 1934.Crossref 5. Klemperer, P.: Myoblastoma of the Striated Muscle , Am. J. Cancer 20:324 ( (Feb.) ) 1934.Crossref 6. Horn, R. C., Jr., and Stout, A. P.: Granular Cell Myoblastoma , Surg., Gynec. & Obst. 76:315 ( (March) ) 1943. 7. Hartz, P. H.: So-Called Granular Cell Myoblastoma of the Thigh With Organoid Structure , Am. J. Clin. Path. 14:582 ( (Nov.) ) 1944. 8. Stout, A. P.: Granular Cell Myoblastoma of the Lumbar Region , Texas State J. Med. 41:580 ( (March) ) 1946. 9. Howe, C. W., and Warren, S.: Myoblastoma , Surgery 16:319 ( (Sept.) ) 1944. 10. Stout, A. P.: Sarcomas of the Soft Parts , J. Missouri M. A. 44:329 ( (May) ) 1947. 11. Powell, E. B.: Granular Cell Myoblastoma , Arch. Path. 42:517 ( (Nov.) ) 1946. 12. Simon, M. A.: Granular Cell Myoblastoma , Am. J. Clin. Path. 17:302 ( (April) ) 1947. 13. Ravich, A.; Stout, A. P., and Ravich, R. A.: Malignant Granular Cell Myoblastoma Involving the Urinary Bladder , Ann. Surg. 121:361 ( (March) ) 1945. 14. Orr, T. G., Jr.: Myoblastoma: Case , Ann. Surg. 122:122 ( (July) ) 1945. 15. Grayzel, D. M., and Friedman, H. H.: Myoblastoma of the Thoracic Wall , Arch. Path. 31:512 ( (April) ) 1941.
Archives of Surgery – American Medical Association
Published: Apr 1, 1949
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