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Gonadotropism: An Etiologic Factor in Migraine and Migraine Variants

Gonadotropism: An Etiologic Factor in Migraine and Migraine Variants Abstract INCIDENCE In a study of migraine and migraine variants conducted by Grimes and reported by Cecil,1 out of 15,000 persons examined, 1200, or 8%, were affected. No age, social, intellectual, or economic group is immune.Migraine or migraine variants occur more frequently in the female, about 70% of the total.Morton and co-workers2 found that 62% of the crimes perpetrated by women were committed in the premenstrual week. REASONS FOR THIS INVESTIGATION Considerable clinical data available strongly suggest that gonadotropism must be considered an etiologic factor in such common conditions as migraine, histaminic cephalgia, tension, and other pain mechanisms due to vasodilation of the cerebral arteries or other vascular dysfunctions.The exact gonadopathy is not clear. I believe, however, that there is frequently both a gonadal imbalance and a deficiency. I further believe that there is more frequently an androgen, rather than estrogen, deficiency in both sexes.In References 1. Cecil, R. L.; McDermott, W., and Wolff, H., Editors: Textbook of Medicine , Ed. 7, Philadelphia, W. B. Saunders Company, 1947, p. 1483. 2. Morton and others: Clinical Study of Premenstrual Tension , Am. JObst.t. & Gynec. 65:1182, 1953. 3. Woolley, D. W. A Study of Antimetabolites , New York, John Wiley & Son, Inc., 1952, p. 60. 4. Ryan, R. E.: Headaches: Diagnosis and Treatment , St. Louis, C.V. Mosby Company, 1954. 5. Revici, E., and Ravich, R. A.: Painful Focus: I. Physiological and Pathological Pain , Bull. Inst. Appl. Biol. 1:12, 1949. 6. Revici, E.; Stoopen, E. Frenk, E., and Ravich, R. A.: The Painful Focus: II. The Relation of Pain to Local Physiocochemical Changes , Bull. Inst. Appl. Biol. 1:21, 1949. 7. Welt, B.: n-Butanol: Its Use in Control of Postoperative Pain in Otorhinolaryngological Surgery , Arch. Otolaryng. 52:549, 1950. 8. Welt, B.: Vertigo , A. M. A. Arch. Otolaryng. 53:273, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

Gonadotropism: An Etiologic Factor in Migraine and Migraine Variants

A.M.A. Archives of Otolaryngology , Volume 61 (4) – Apr 1, 1955

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1955.00720020417005
Publisher site
See Article on Publisher Site

Abstract

Abstract INCIDENCE In a study of migraine and migraine variants conducted by Grimes and reported by Cecil,1 out of 15,000 persons examined, 1200, or 8%, were affected. No age, social, intellectual, or economic group is immune.Migraine or migraine variants occur more frequently in the female, about 70% of the total.Morton and co-workers2 found that 62% of the crimes perpetrated by women were committed in the premenstrual week. REASONS FOR THIS INVESTIGATION Considerable clinical data available strongly suggest that gonadotropism must be considered an etiologic factor in such common conditions as migraine, histaminic cephalgia, tension, and other pain mechanisms due to vasodilation of the cerebral arteries or other vascular dysfunctions.The exact gonadopathy is not clear. I believe, however, that there is frequently both a gonadal imbalance and a deficiency. I further believe that there is more frequently an androgen, rather than estrogen, deficiency in both sexes.In References 1. Cecil, R. L.; McDermott, W., and Wolff, H., Editors: Textbook of Medicine , Ed. 7, Philadelphia, W. B. Saunders Company, 1947, p. 1483. 2. Morton and others: Clinical Study of Premenstrual Tension , Am. JObst.t. & Gynec. 65:1182, 1953. 3. Woolley, D. W. A Study of Antimetabolites , New York, John Wiley & Son, Inc., 1952, p. 60. 4. Ryan, R. E.: Headaches: Diagnosis and Treatment , St. Louis, C.V. Mosby Company, 1954. 5. Revici, E., and Ravich, R. A.: Painful Focus: I. Physiological and Pathological Pain , Bull. Inst. Appl. Biol. 1:12, 1949. 6. Revici, E.; Stoopen, E. Frenk, E., and Ravich, R. A.: The Painful Focus: II. The Relation of Pain to Local Physiocochemical Changes , Bull. Inst. Appl. Biol. 1:21, 1949. 7. Welt, B.: n-Butanol: Its Use in Control of Postoperative Pain in Otorhinolaryngological Surgery , Arch. Otolaryng. 52:549, 1950. 8. Welt, B.: Vertigo , A. M. A. Arch. Otolaryng. 53:273, 1953.

Journal

A.M.A. Archives of OtolaryngologyAmerican Medical Association

Published: Apr 1, 1955

References