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Goblet Cell Density in Thermal and Chemical Injuries-Reply

Goblet Cell Density in Thermal and Chemical Injuries-Reply Abstract In Reply. —Dr Brent makes some interesting suggestions; however, his hypothesis regarding "apparent" as opposed to "real" goblet cell density requires at least an increase in the remaining cell density at the scarred ocular surface, which is not the case in our series; we observed no statistical difference in conjunctival epithelial density between injured and normal eyes. As well, our preliminary results indicated that the adhesive power of epithelia, including goblet cells, to the filtering paper was less in scarred than in normal conjunctiva. Our data regarding goblet cell density were unaffected by this variability, however, due to our method of calculation. Supposing goblet cell density were to be reflected in conjunctival differentiation,1 a marked decrease in goblet cell density during the acute stage of chemical injury2 may be due to insufficient conjunctival differentiation, not to simple inflammation or direct goblet cell damage. Further investigations should be directed References 1. Thoft RA, Friend J, Kinoshita S, et al: Ocular cicatricial pemphigoid associated with hyperproliferation of the conjunctival epithelium . Am J Ophthalmol 1984;98:37-42.Crossref 2. Ralph RA: Conjunctival goblet cell density in normal subjects and in dry eye syndromes . Invest Ophthalmol Vis Sci 1975;14:299-302. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Goblet Cell Density in Thermal and Chemical Injuries-Reply

Archives of Ophthalmology , Volume 106 (6) – Jun 1, 1988

Goblet Cell Density in Thermal and Chemical Injuries-Reply

Abstract

Abstract In Reply. —Dr Brent makes some interesting suggestions; however, his hypothesis regarding "apparent" as opposed to "real" goblet cell density requires at least an increase in the remaining cell density at the scarred ocular surface, which is not the case in our series; we observed no statistical difference in conjunctival epithelial density between injured and normal eyes. As well, our preliminary results indicated that the adhesive power of epithelia,...
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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1988.01060130792015
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply. —Dr Brent makes some interesting suggestions; however, his hypothesis regarding "apparent" as opposed to "real" goblet cell density requires at least an increase in the remaining cell density at the scarred ocular surface, which is not the case in our series; we observed no statistical difference in conjunctival epithelial density between injured and normal eyes. As well, our preliminary results indicated that the adhesive power of epithelia, including goblet cells, to the filtering paper was less in scarred than in normal conjunctiva. Our data regarding goblet cell density were unaffected by this variability, however, due to our method of calculation. Supposing goblet cell density were to be reflected in conjunctival differentiation,1 a marked decrease in goblet cell density during the acute stage of chemical injury2 may be due to insufficient conjunctival differentiation, not to simple inflammation or direct goblet cell damage. Further investigations should be directed References 1. Thoft RA, Friend J, Kinoshita S, et al: Ocular cicatricial pemphigoid associated with hyperproliferation of the conjunctival epithelium . Am J Ophthalmol 1984;98:37-42.Crossref 2. Ralph RA: Conjunctival goblet cell density in normal subjects and in dry eye syndromes . Invest Ophthalmol Vis Sci 1975;14:299-302.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jun 1, 1988

References