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Glyceryl Triacetate (Triacetin) as a Fungicide

Glyceryl Triacetate (Triacetin) as a Fungicide Abstract In 1952, Knight,* when studying the lipase activity of molds, observed in vitro inhibition of strains of Aspergillus and Penicillium when glyceryl triacetate (triacetin) was added to homogenized Sabouraud's medium. Concentrations of 0.05% glyceryl triacetate were found to effectively inhibit the growth of these two molds. Pathogenic fungi such as Microsporum audouini, Trichophyton mentagrophytes, Microsporum lanosum, and Epidermophyton floccosum were similarly inhibited in vitro with the addition of 0.1% to 0.3% glyceryl triacetate. Knight presumed that a lipase of these molds and fungi was capable of hydrolyzing glyceryl triacetate so that products of this reaction were injurious to the growth of the organisms. If blood serum was added to the medium, the action of glyceryl triacetate was potentiated, probably through the action of the serum lipase. When spores of some species of molds and fungi appeared to be resistant to the action of glyceryl triacetate, no References 1. Knight, S., Ph.D., Department of Bacteriology, University of Wisconsin: unpublished data. 2. Prepared by the G. F. Harvey Company, Saratoga Springs, N. Y. 3. Rothman, S.: A. M. A. Arch. Dermat. & Syph. 67:239-246, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Glyceryl Triacetate (Triacetin) as a Fungicide

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550070075014
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1952, Knight,* when studying the lipase activity of molds, observed in vitro inhibition of strains of Aspergillus and Penicillium when glyceryl triacetate (triacetin) was added to homogenized Sabouraud's medium. Concentrations of 0.05% glyceryl triacetate were found to effectively inhibit the growth of these two molds. Pathogenic fungi such as Microsporum audouini, Trichophyton mentagrophytes, Microsporum lanosum, and Epidermophyton floccosum were similarly inhibited in vitro with the addition of 0.1% to 0.3% glyceryl triacetate. Knight presumed that a lipase of these molds and fungi was capable of hydrolyzing glyceryl triacetate so that products of this reaction were injurious to the growth of the organisms. If blood serum was added to the medium, the action of glyceryl triacetate was potentiated, probably through the action of the serum lipase. When spores of some species of molds and fungi appeared to be resistant to the action of glyceryl triacetate, no References 1. Knight, S., Ph.D., Department of Bacteriology, University of Wisconsin: unpublished data. 2. Prepared by the G. F. Harvey Company, Saratoga Springs, N. Y. 3. Rothman, S.: A. M. A. Arch. Dermat. & Syph. 67:239-246, 1953.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1956

References