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Gilles de la Tourette's Syndrome: Remission With Haloperidol

Gilles de la Tourette's Syndrome: Remission With Haloperidol To the Editor:— A syndrome comprised of motor tics and coprolalia was reported by Gilles de la Tourette in 1885.1 Characteristically, the syndrome consists of numerous vocal and motor tics accentuated during times of emotional stress. Coprolalia occurs later and is considered a pathognomonic sign. The onset is usually between 5 and 10 years of age, and the prognosis almost uniformly poor. Psychotherapeutic and psychopharmacological measures employed have been of very little benefit.2-6 In 1961, Seignot used haloperidol for Gilles de la Tourette's syndrome.7 The patient was a 35-year-old man who had an estimated 1,000 tics a day and coprolalia since the age of 10 years, except for a period of two years in adolescence when he had spontaneous remission. Haloperidol decreased the patient's tics to two to three times per day, and completely alleviated the coprolalia. Four additional cases with marked beneficial response to haloperidol have http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Gilles de la Tourette's Syndrome: Remission With Haloperidol

Boris, Marvin
JAMA , Volume 205 (9) – Aug 26, 1968
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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1968.03140350058021
Publisher site
See Article on Publisher Site

Abstract

To the Editor:— A syndrome comprised of motor tics and coprolalia was reported by Gilles de la Tourette in 1885.1 Characteristically, the syndrome consists of numerous vocal and motor tics accentuated during times of emotional stress. Coprolalia occurs later and is considered a pathognomonic sign. The onset is usually between 5 and 10 years of age, and the prognosis almost uniformly poor. Psychotherapeutic and psychopharmacological measures employed have been of very little benefit.2-6 In 1961, Seignot used haloperidol for Gilles de la Tourette's syndrome.7 The patient was a 35-year-old man who had an estimated 1,000 tics a day and coprolalia since the age of 10 years, except for a period of two years in adolescence when he had spontaneous remission. Haloperidol decreased the patient's tics to two to three times per day, and completely alleviated the coprolalia. Four additional cases with marked beneficial response to haloperidol have

Journal

JAMA – American Medical Association

Published: Aug 26, 1968

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