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Giant Fibroadenomata of the Breast in a Prepubertal Girl: A Case Report with Observations of Hormonal Influences

Giant Fibroadenomata of the Breast in a Prepubertal Girl: A Case Report with Observations of... Abstract Introduction Fibroadenoma of the breast is a slowly growing benign tumor occurring in females usually before the age of 30. The microscopic appearance of the tumor is one of proliferating connective tissue and maturing epithelium. Any fibroadenoma which occupies a major portion of the breast and weighs more than 500 gm. is considered to be a "giant fibroadenoma" by McDonald.8Fibroadenomata have been recognized as benign breast tumors for many years. Sir Astley Cooper2 described the tumors in 1829 as belonging to a group he called "chronic mammary tumors." Seventeen years later Brodie1 categorized fibroadenoma as the fourth chronologic stage in a series of breast tumors he called "sero-cystic tumors of the female breast"; he considered giant fibroadenoma as the fifth stage in the evolution of these mammary tumors. The most comprehensive modern study of fibroadenomata of the female breast was made by Oliver9 in 1934. References 1. Brodie, B. C.: Lectures Illustrative of Various Subjects in Pathology and Surgery , London, 1846, Lecture 7, p. 148. 2. Cooper, A.: Illustrations of the Diseases of the Breast , London, 1829. 3. Geschickter, C. F.; Lewis, D., and Hartman, C. G.: Tumors of the Breast Related to the Oestrin Hormone , Am. J. Cancer 21:828, 1934.Crossref 4. Haagensen, C. D.: Diseases of the Breast , Philadelphia, W. B. Saunders Company, 1956. 5. Hendrick, J. W.: Results of Treatment of Cystic Disease of the Breast , Surgery 44:457, 1958. 6. Jonas, H., and Hollander, V.: The Assay of Estradiol-Sensitive Transhydrogenase , Cancer 12:127, 1959.Crossref 7. Kier, L. C.; Hickey, R. C.; Keetal, W. C., and Womack, N. A.: Endocrine Relationships in Benign Lesions of the Breast , Ann. Surg. 135:782, 1952.Crossref 8. McDonald, J. R., and Harrington, S. W.: Giant Fibroadenoma of the Breast , Ann. Surg. 131:243, 1950.Crossref 9. Oliver, R. L., and Major, R. C.: Cyclomastopathy: A Physio-Pathological Conception of Some Benign Breast Tumors, with an Analysis of 400 Cases , Am. J. Cancer , 21:1, 1934.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

Giant Fibroadenomata of the Breast in a Prepubertal Girl: A Case Report with Observations of Hormonal Influences

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1960.01290210133027
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction Fibroadenoma of the breast is a slowly growing benign tumor occurring in females usually before the age of 30. The microscopic appearance of the tumor is one of proliferating connective tissue and maturing epithelium. Any fibroadenoma which occupies a major portion of the breast and weighs more than 500 gm. is considered to be a "giant fibroadenoma" by McDonald.8Fibroadenomata have been recognized as benign breast tumors for many years. Sir Astley Cooper2 described the tumors in 1829 as belonging to a group he called "chronic mammary tumors." Seventeen years later Brodie1 categorized fibroadenoma as the fourth chronologic stage in a series of breast tumors he called "sero-cystic tumors of the female breast"; he considered giant fibroadenoma as the fifth stage in the evolution of these mammary tumors. The most comprehensive modern study of fibroadenomata of the female breast was made by Oliver9 in 1934. References 1. Brodie, B. C.: Lectures Illustrative of Various Subjects in Pathology and Surgery , London, 1846, Lecture 7, p. 148. 2. Cooper, A.: Illustrations of the Diseases of the Breast , London, 1829. 3. Geschickter, C. F.; Lewis, D., and Hartman, C. G.: Tumors of the Breast Related to the Oestrin Hormone , Am. J. Cancer 21:828, 1934.Crossref 4. Haagensen, C. D.: Diseases of the Breast , Philadelphia, W. B. Saunders Company, 1956. 5. Hendrick, J. W.: Results of Treatment of Cystic Disease of the Breast , Surgery 44:457, 1958. 6. Jonas, H., and Hollander, V.: The Assay of Estradiol-Sensitive Transhydrogenase , Cancer 12:127, 1959.Crossref 7. Kier, L. C.; Hickey, R. C.; Keetal, W. C., and Womack, N. A.: Endocrine Relationships in Benign Lesions of the Breast , Ann. Surg. 135:782, 1952.Crossref 8. McDonald, J. R., and Harrington, S. W.: Giant Fibroadenoma of the Breast , Ann. Surg. 131:243, 1950.Crossref 9. Oliver, R. L., and Major, R. C.: Cyclomastopathy: A Physio-Pathological Conception of Some Benign Breast Tumors, with an Analysis of 400 Cases , Am. J. Cancer , 21:1, 1934.Crossref

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Apr 1, 1960

References