Access the full text.
Sign up today, get DeepDyve free for 14 days.
B. Bett (2005)
Large or multiple congenital melanocytic nevi: occurrence of cutaneous melanoma in 1008 persons.Journal of the American Academy of Dermatology, 52 5
H. Grossniklaus, W. Green, M. Luckenbach, C. Chan (1987)
Conjunctival Lesions in Adults: A Clinical and Histopathologic ReviewCornea, 6
L. Levecq, P. Potter, J. Jamart (2010)
Conjunctival nevi clinical features and therapeutic outcomes.Ophthalmology, 117 1
H. Price, J. Schaffer (2010)
Congenital melanocytic nevi-when to worry and how to treat: Facts and controversies.Clinics in dermatology, 28 3
M. Tomita, H. Goto, R. Muramatsu, M. Usui (2006)
Treatment of large conjunctival nevus by resection and reconstruction using amniotic membraneGraefe's Archive for Clinical and Experimental Ophthalmology, 244
B. Marr (2019)
Intraocular TumorsThe Columbia Guide to Basic Elements of Eye Care
Hyunjin Kim, S. Mccormick, S. Nath, B. Moskowitz, T. Milman (2010)
Melanocytic Nevi of the Tarsal Conjunctiva: Clinicopathologic Case Series With Review of LiteratureOphthalmic Plastic & Reconstructive Surgery, 26
S. Yun, O. Kwon, J. Han, S. Kweon, M. Lee, D.Y. Lee, M. Kim, Y. Kim, T. Yoon, K. Chung, I.H. Kim, K.H. Kim, K. Suh, S. Lee, Y. Seo, K. Kim, H. Park, M. Roh, K. Ahn, T. Yoon, M. Kim, K. Li, J.S. Park, B. Shin, J. Ko, H. Ahn, H. Kim, S.D. Park, S. Jang, Y. Won (2012)
Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea: a nationwide retrospective studyBritish Journal of Dermatology, 166
C. Bianciotto, C. Shields, J. Guzmán, Massi Romanelli-Gobbi, D. Mazzuca, W. Green, J. Shields (2011)
Assessment of anterior segment tumors with ultrasound biomicroscopy versus anterior segment optical coherence tomography in 200 cases.Ophthalmology, 118 7
C. Shields, J. Shields (2004)
Tumors of the conjunctiva and cornea.Survey of ophthalmology, 49 1
N. Gerner, J. Nørregaard, O. Jensen, J. Prause (2009)
Conjunctival naevi in Denmark 1960-1980. A 21-year follow-up study.Acta ophthalmologica Scandinavica, 74 4
C. Shields, Airaj Fasiuddin, A. Mashayekhi, J. Shields (2004)
Conjunctival nevi: clinical features and natural course in 410 consecutive patients.Archives of ophthalmology, 122 2
(2010)
Congenitalmelanocyticnevi
C. Shields, I. Belinsky, Massi Romanelli-Gobbi, Juan Guzman, D. Mazzuca, W. Green, C. Bianciotto, J. Shields (2011)
Anterior segment optical coherence tomography of conjunctival nevus.Ophthalmology, 118 5
C. Shields, H. Demirci, E. Karatza, J. Shields (2004)
Clinical survey of 1643 melanocytic and nonmelanocytic conjunctival tumors.Ophthalmology, 111 9
J. Shields, C. Shields, A. Mashayekhi, B. Marr, R. Benavides, A. Thangappan, L. Phan, R. Eagle (2008)
Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lecture.Ophthalmology, 115 3
C. Shields, J. Markowitz, I. Belinsky, H. Schwartzstein, N. George, S. Lally, A. Mashayekhi, J. Shields (2011)
Conjunctival melanoma: outcomes based on tumor origin in 382 consecutive cases.Ophthalmology, 118 2
ImportanceConjunctival nevus is the most common tumor of the ocular surface and we selected the largest nevi to evaluate for clinical features and outcomes. ObjectiveTo describe the clinical features and outcomes of giant (≥10 mm diameter) conjunctival nevus. Design, Setting, and PatientsRetrospective case series of 618 patients with conjunctival nevus, 32 of which had giant conjunctival nevus, treated at an ocular oncology service between July 1, 1974, and June 30, 2012. ExposuresObservation, excisional biopsy, and cryotherapy. Main Outcomes and MeasuresManagement, nevus recurrence, and nevus transformation into melanoma. ResultsOf 618 patients with conjunctival nevus, 32 (5%) were classified as having giant conjunctival nevus. The mean patient age at diagnosis was 34 years. Of those with giant conjunctival nevus, a history of an increase in nevus base or thickness was noted in 15 cases (47%) and an increase in color intensity in 2 cases (6%). The giant nevus involved cornea in 11 cases (34%), limbus in 23 (72%), bulbar conjunctiva in 31 (97%), fornix in 9 (28%), tarsus in 3 (9%), semilunar fold in 10 (31%), and caruncle in 7 (22%). The nevi had mean diameter of 16 mm and mean thickness of 2 mm. On slitlamp examination, intrinsic cysts were identified in 25 cases (78%), intrinsic blood vessels in 26 (81%), and feeder vessels in 22 (69%). Management included excisional biopsy with cryotherapy in 23 cases (72%) and observation in 9 cases (28%). Amniotic membrane graft reconstruction was used following excision in 3 cases (13%). Malignant melanoma developed within the giant nevus in 1 case after 23 years of observation. Postexcisional biopsy, nevus recurrence was detected in 4 cases (17%), pseudopterygium in 1 (4%), dry eye in 1 (4%), and eyelid blepharoptosis in 1 (4%). Conclusions and RelevanceIn an ocular oncology practice, giant conjunctival nevus represents 5% of conjunctival nevi. This benign tumor rarely transforms into conjunctival melanoma. Management alternatives include observation or wide excisional biopsy, cryotherapy, and reconstruction, possibly with amniotic membrane graft.
JAMA Ophthalmology – American Medical Association
Published: Jul 1, 2013
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.