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Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism ORIGINAL ARTICLE ONLINE FIRST Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism Joachim Hallmayer, MD; Sue Cleveland, BS; Andrea Torres, MA; Jennifer Phillips, PhD; Brianne Cohen, BA; Tiffany Torigoe, BA; Janet Miller, PhD; Angie Fedele, BA; Jack Collins, MBA; Karen Smith, BS; Linda Lotspeich, MD; Lisa A. Croen, PhD; Sally Ozonoff, PhD; Clara Lajonchere, PhD; Judith K. Grether, PhD; Neil Risch, PhD Context: Autism is considered the most heritable of neu- fidence interval [CI], 0.42-0.74) and 0.21 for 31 dizy- rodevelopmental disorders, mainly because of the large gotic pairs (95% CI, 0.09-0.43); for female twins, the difference in concordance rates between monozygotic and concordance was 0.60 for 7 monozygotic pairs (95% CI, dizygotic twins. 0.28-0.90) and 0.27 for 10 dizygotic pairs (95% CI, 0.09- 0.69). For ASD, the probandwise concordance for male Objective: To provide rigorous quantitative estimates twins was 0.77 for 45 monozygotic pairs (95% CI, 0.65- of genetic heritability of autism and the effects of shared 0.86) and 0.31 for 45 dizygotic pairs (95% CI, 0.16- environment. 0.46); for female twins, the concordance was 0.50 for 9 monozygotic pairs (95% CI, 0.16-0.84) and 0.36 for 13 Design, Setting, and Participants: Twin pairs with dizygotic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2011.76
pmid
21727249
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE ONLINE FIRST Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism Joachim Hallmayer, MD; Sue Cleveland, BS; Andrea Torres, MA; Jennifer Phillips, PhD; Brianne Cohen, BA; Tiffany Torigoe, BA; Janet Miller, PhD; Angie Fedele, BA; Jack Collins, MBA; Karen Smith, BS; Linda Lotspeich, MD; Lisa A. Croen, PhD; Sally Ozonoff, PhD; Clara Lajonchere, PhD; Judith K. Grether, PhD; Neil Risch, PhD Context: Autism is considered the most heritable of neu- fidence interval [CI], 0.42-0.74) and 0.21 for 31 dizy- rodevelopmental disorders, mainly because of the large gotic pairs (95% CI, 0.09-0.43); for female twins, the difference in concordance rates between monozygotic and concordance was 0.60 for 7 monozygotic pairs (95% CI, dizygotic twins. 0.28-0.90) and 0.27 for 10 dizygotic pairs (95% CI, 0.09- 0.69). For ASD, the probandwise concordance for male Objective: To provide rigorous quantitative estimates twins was 0.77 for 45 monozygotic pairs (95% CI, 0.65- of genetic heritability of autism and the effects of shared 0.86) and 0.31 for 45 dizygotic pairs (95% CI, 0.16- environment. 0.46); for female twins, the concordance was 0.50 for 9 monozygotic pairs (95% CI, 0.16-0.84) and 0.36 for 13 Design, Setting, and Participants: Twin pairs with dizygotic

Journal

JAMA Psychiatry – American Medical Association

Published: Nov 1, 2011

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