ORIGINAL ARTICLE ONLINE FIRST Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism Joachim Hallmayer, MD; Sue Cleveland, BS; Andrea Torres, MA; Jennifer Phillips, PhD; Brianne Cohen, BA; Tiffany Torigoe, BA; Janet Miller, PhD; Angie Fedele, BA; Jack Collins, MBA; Karen Smith, BS; Linda Lotspeich, MD; Lisa A. Croen, PhD; Sally Ozonoff, PhD; Clara Lajonchere, PhD; Judith K. Grether, PhD; Neil Risch, PhD Context: Autism is considered the most heritable of neu- fidence interval [CI], 0.42-0.74) and 0.21 for 31 dizy- rodevelopmental disorders, mainly because of the large gotic pairs (95% CI, 0.09-0.43); for female twins, the difference in concordance rates between monozygotic and concordance was 0.60 for 7 monozygotic pairs (95% CI, dizygotic twins. 0.28-0.90) and 0.27 for 10 dizygotic pairs (95% CI, 0.09- 0.69). For ASD, the probandwise concordance for male Objective: To provide rigorous quantitative estimates twins was 0.77 for 45 monozygotic pairs (95% CI, 0.65- of genetic heritability of autism and the effects of shared 0.86) and 0.31 for 45 dizygotic pairs (95% CI, 0.16- environment. 0.46); for female twins, the concordance was 0.50 for 9 monozygotic pairs (95% CI, 0.16-0.84) and 0.36 for 13 Design, Setting, and Participants: Twin pairs with dizygotic
JAMA Psychiatry – American Medical Association
Published: Nov 1, 2011
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