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Generalized Cytomegalic Inclusion Disease: Report of Two Cases With Associated Fungal Infection, One Involving Aspergillosis, the Second With Candidiasis

Generalized Cytomegalic Inclusion Disease: Report of Two Cases With Associated Fungal Infection,... Abstract SINCE RIBBERT,1 in 1904, first reported the presence of inclusion bodies in the cells of the kidney and parotid gland of a stillborn infant and Jesionek and Kiolemenoglou2 similarly cited inclusions in the cells of the kidney, liver, and lungs of another stillborn infant, cytomegalic inclusion disease has been reported frequently as a disease of newborn infants, infants beyond the neonatal period, and less commonly, older children3 and adults.4,6 We wish to report two infants with cytomegalic inclusion disease in combination with a fungal infection, since we could find no definite reports of such cases in infancy. In the first case cytomegalic inclusion disease was found in combination with aspergillosis; in the second with candidiasis. Aspergillosis is rare in the pediatric age group being most commonly a disease of middle age. Allan and Andersen6 reviewed six cases of primary aspergillosis in childhood to which they References 1. Ribbert, H.: Uber Protozoenartige Zellen in der Niere einer syphilitschen Neugeborenen und in der Parotis von Kindern , Zbl Allg Path 15:945, 1904. 2. Jesionek, and Kiolemenoglou: Uber einen Befund von protozoenartigen Gebilden in den Organen eines heriditarluetischen Fötus , Munchen Med Wschr 51:1905, 1904. 3. Smith, M.G., and Vellios, F.: Inclusion Disease or Generalized Salivary Gland Virus Infection , Arch Path 50:862, 1950. 4. Peace, R.J.: Cytomegalic Inclusion Disease in Adults: A Complication of Neoplastic Disease of the Hemopoietic and Reticulohistiocytic Systems , Amer J Med 24:48, 1958.Crossref 5. Fisher, E.R., and Davis, E.: Cytomegalic Inclusion Disease in the Adult , New Eng J Med 258:1036, 1958.Crossref 6. Allan, G.W., and Andersen, D.H.: Generalized Aspergillosis in an Infant 18 Days of Age , Pediatrics 26:432, 1960. 7. Katz, S.L., and Kibrick, S.: Nonbacterial Infections of the Newborn , Pediat Clin N Amer 8:493, 1961. 8. Kozinn, P.J., et al: Neonatal Candidiasis , Pediat Clin N Amer 5:803, 1958. 9. Dobias, B.: Moniliasis in Pediatrics , Amer J Dis Child 94:234, 1957. 10. Sonnenschein, H.; Clark, H.L.; and Taschdjian, C.L.: Congenital Cutaneous Candidiasis in a Premature Infant , Amer J Dis Child 99:81, 1960. 11. Winter, W.D., Jr.: Candida (Monilia) Infections in Children , Pediat Clin N Amer 2:151, 1955. 12. Ebbs, J.H.: Oesophagitis in Infancy , Arch Dis Child 13:211, 1938.Crossref 13. Reye, D.: Oesophagitis of Infants , Med J Aust 2: 673, 1941. 14. Wolff, O.H., et al: Thrush Oesophagitis With Pharyngeal Incoordination Treated With Hydroxystilbamidine , Lancet 1:991, 1955.Crossref 15. Adams, J.M.: A Revaluation of the Pneumonias of Infancy , J Pediat 25:369, 1944.Crossref 16. Beckmann, A.J., and Navarro, J.E.: Pneumonia Complicating Oral Thrush Treated with Mycostatin, a New Antifungal Antibiotic , J Pediat 46:587, 1955.Crossref 17. Woodruff, P.W., and Hesseltine, H.C.: Relationship of Oral Thrush to Vaginal Mycosis and the Incidence of Each , Amer J Obstet Gynec 36:467, 1938. 18. Zimmerman, L.E.: Fatal Fungus Infections Complicating Other Diseases , Amer J Clin Path 25:46, 1955. 19. Winter, W.D., Jr., and Foley, G.E.: Candida Infections in Children With Neoplastic Disease: Influence of Therapy With Antibiotics and Steroid Hormones , Pediatrics 18:595, 1956. 20. Sutphin, A.; Albright, F.; and McCune, D.J.: Five Cases (3 in Siblings) of Idiopathic Hypoparathyroidism Associated With Moniliasis , J Clin Endocr 3:625, 1943.Crossref 21. Craig, J.M., and Farber, S.: The Development of Disseminated Visceral Mycosis During Therapy for Acute Leukemia, Scientific Proceedings , Amer J Path 29:601, 1953. 22. Kunstadter, R.H.; MacLean, H.; and Greengard, J.: Mycotic Endocarditis Due to Candida albicans , JAMA 149: 829, 1952.Crossref 23. Duhig, J.V., and Mead, M.: Systemic Mycosis Due to Monilia albicans , Med J Aust 1:179, 1951. 24. Woods, J.W.; Manning, I.H., Jr.; and Patterson, C. N.: Monilial Infections Complicating the Therapeutic Use of Antibiotics , JAMA 145:207, 1951.Crossref 25. DePape, A.J.: Moniliasis Associated With Staphylococcal Infection After Antibiotic Therapy , Canad Med Assoc J Med 260:21, 1959. 26. Margileth, A.M.: The Diagnosis and Treatment of Generalized Cytomegalic Inclusion Disease of the Newborn , Pediatrics 15:270, 1955. 27. Potter, E.L.: Pathology of the Fetus and Infant , ed 2, Chicago: Year Book Medical Publishers Inc., 1961. 28. Paradis, A.J., and Roberts, L.: Endogenous Ocular Aspergillosis: Report of a Case in an Infant With Cytomegalic Inclusion Disease , Arch Ophthal 69:765, 1963.Crossref 29. Gitlin, D.; Gross, P.A.M.; and Janeway, C.A.: The Gamma Globulins and Their Clinical Significance , New Eng J Med 260:21, 1959.Crossref 30. Medearis, D.N., Jr.: Cytomegalic Inclusion Disease: An Analysis of the Clinical Features Based on the Literature and Six Additional Cases , Pediatrics 19:467, 1957. 31. Birdsong, M., et al: Generalized Cytomegalic Inclusion Disease in Newborn Infants , JAMA 162:1305, 1956Crossref 32. Bellamy, J.: Cytomegalic Inclusion-Body Disease Occurring in Twins , Amer J Clin Path 24:1040, 1954. 33. Elliott, G.B., and Elliott, K.A.: Observations on Cerebral Cytomegalic Inclusion Disease of the Foetus and Newborn , Arch Dis Child 37:34, 1962.Crossref 34. Akkoyunlu, A., and Yücel, F.A.: Aspergillose bronchopulmonaire et encéphalomeningée chez un nouveau-né de 20 jours , Arch Franc Pediat 14:615, 1957. 35. Luke, J.L.; Bolande, R.P.; and Gross, S.: Generalized Aspergillosis and Aspergillus Endocarditis in Infancy , Pediatrics 31:115, 1963. 36. Cawley, E.P.: Aspergillosis and the Aspergilli: Report of a Unique Case of the Disease , Arch Intern Med 80:423, 1947.Crossref 37. Conen, P.E., et al: Invasive Primary Aspergillosis of the Lung With Cerebral Metastasis and Complete Recovery , Dis Chest 42:88, 1962.Crossref 38. Kozinn, P.J.; Taschdjian, C.L.; and Wiener, H.: Incidence and Pathogenesis of Neonatal Candidiasis , Pediatrics 21:421, 1958. 39. Pappenfort, R.B., Jr., and Schnall, E.S.: Moniliasis in Patients Treated With Aureomycin: Clinical and Laboratory Evidence That Aureomycin Stimulates the Growth of Candida albicans , Arch Intern Med 88:729. 1951.Crossref 40. Moore, M.: In vivo and in Vitro Effect of Aureomycin Hydrochloride on Syringospora (Monilia, Candida) albicans , J Lab Clin Med 37:703, 1951. 41. Huppert, M.; MacPherson, D.A.; and Cazin, J.: Pathogenesis of Candida albicans Infection Following Antibiotic Therapy: 1. The Effect of Antibiotics on the Growth of Candida albicans , J Bact 65:171, 1953. 42. Sharp, J.L.: The Growth of Candida albicans During Antibiotic Therapy , Lancet 1:390, 1954.Crossref 43. McGovern, J.J., et al: The Effect of Aureomycin and Chloramphenicol on the Fungal and Bacterial Flora of Children , New Eng J Med 248:397, 1953.Crossref 44. Gitlin, D., and Craig, J.M.: Thymic Alymphoplasia and Lymphocytic Hypoplasia and Increased Susceptibility to Infection , the Society for Pediatric Research Program and Abstracts, 33rd Annual Meeting, Atlantic City, NJ, (May) 1-2, 1963, p 1. 45. Yakovac, W.C.: Thymic Dysplasia in Congenital A-gammaglobulinemia , the Society for Pediatric Research Program and Abstracts, 33rd Annual Meeting, Atlantic City, NJ, (May) 1-2, 1963, p 2. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Generalized Cytomegalic Inclusion Disease: Report of Two Cases With Associated Fungal Infection, One Involving Aspergillosis, the Second With Candidiasis

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1965.02090030333019
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Abstract

Abstract SINCE RIBBERT,1 in 1904, first reported the presence of inclusion bodies in the cells of the kidney and parotid gland of a stillborn infant and Jesionek and Kiolemenoglou2 similarly cited inclusions in the cells of the kidney, liver, and lungs of another stillborn infant, cytomegalic inclusion disease has been reported frequently as a disease of newborn infants, infants beyond the neonatal period, and less commonly, older children3 and adults.4,6 We wish to report two infants with cytomegalic inclusion disease in combination with a fungal infection, since we could find no definite reports of such cases in infancy. In the first case cytomegalic inclusion disease was found in combination with aspergillosis; in the second with candidiasis. Aspergillosis is rare in the pediatric age group being most commonly a disease of middle age. Allan and Andersen6 reviewed six cases of primary aspergillosis in childhood to which they References 1. Ribbert, H.: Uber Protozoenartige Zellen in der Niere einer syphilitschen Neugeborenen und in der Parotis von Kindern , Zbl Allg Path 15:945, 1904. 2. Jesionek, and Kiolemenoglou: Uber einen Befund von protozoenartigen Gebilden in den Organen eines heriditarluetischen Fötus , Munchen Med Wschr 51:1905, 1904. 3. Smith, M.G., and Vellios, F.: Inclusion Disease or Generalized Salivary Gland Virus Infection , Arch Path 50:862, 1950. 4. Peace, R.J.: Cytomegalic Inclusion Disease in Adults: A Complication of Neoplastic Disease of the Hemopoietic and Reticulohistiocytic Systems , Amer J Med 24:48, 1958.Crossref 5. Fisher, E.R., and Davis, E.: Cytomegalic Inclusion Disease in the Adult , New Eng J Med 258:1036, 1958.Crossref 6. Allan, G.W., and Andersen, D.H.: Generalized Aspergillosis in an Infant 18 Days of Age , Pediatrics 26:432, 1960. 7. Katz, S.L., and Kibrick, S.: Nonbacterial Infections of the Newborn , Pediat Clin N Amer 8:493, 1961. 8. Kozinn, P.J., et al: Neonatal Candidiasis , Pediat Clin N Amer 5:803, 1958. 9. Dobias, B.: Moniliasis in Pediatrics , Amer J Dis Child 94:234, 1957. 10. Sonnenschein, H.; Clark, H.L.; and Taschdjian, C.L.: Congenital Cutaneous Candidiasis in a Premature Infant , Amer J Dis Child 99:81, 1960. 11. Winter, W.D., Jr.: Candida (Monilia) Infections in Children , Pediat Clin N Amer 2:151, 1955. 12. Ebbs, J.H.: Oesophagitis in Infancy , Arch Dis Child 13:211, 1938.Crossref 13. Reye, D.: Oesophagitis of Infants , Med J Aust 2: 673, 1941. 14. Wolff, O.H., et al: Thrush Oesophagitis With Pharyngeal Incoordination Treated With Hydroxystilbamidine , Lancet 1:991, 1955.Crossref 15. Adams, J.M.: A Revaluation of the Pneumonias of Infancy , J Pediat 25:369, 1944.Crossref 16. Beckmann, A.J., and Navarro, J.E.: Pneumonia Complicating Oral Thrush Treated with Mycostatin, a New Antifungal Antibiotic , J Pediat 46:587, 1955.Crossref 17. Woodruff, P.W., and Hesseltine, H.C.: Relationship of Oral Thrush to Vaginal Mycosis and the Incidence of Each , Amer J Obstet Gynec 36:467, 1938. 18. Zimmerman, L.E.: Fatal Fungus Infections Complicating Other Diseases , Amer J Clin Path 25:46, 1955. 19. Winter, W.D., Jr., and Foley, G.E.: Candida Infections in Children With Neoplastic Disease: Influence of Therapy With Antibiotics and Steroid Hormones , Pediatrics 18:595, 1956. 20. Sutphin, A.; Albright, F.; and McCune, D.J.: Five Cases (3 in Siblings) of Idiopathic Hypoparathyroidism Associated With Moniliasis , J Clin Endocr 3:625, 1943.Crossref 21. Craig, J.M., and Farber, S.: The Development of Disseminated Visceral Mycosis During Therapy for Acute Leukemia, Scientific Proceedings , Amer J Path 29:601, 1953. 22. Kunstadter, R.H.; MacLean, H.; and Greengard, J.: Mycotic Endocarditis Due to Candida albicans , JAMA 149: 829, 1952.Crossref 23. Duhig, J.V., and Mead, M.: Systemic Mycosis Due to Monilia albicans , Med J Aust 1:179, 1951. 24. Woods, J.W.; Manning, I.H., Jr.; and Patterson, C. N.: Monilial Infections Complicating the Therapeutic Use of Antibiotics , JAMA 145:207, 1951.Crossref 25. DePape, A.J.: Moniliasis Associated With Staphylococcal Infection After Antibiotic Therapy , Canad Med Assoc J Med 260:21, 1959. 26. Margileth, A.M.: The Diagnosis and Treatment of Generalized Cytomegalic Inclusion Disease of the Newborn , Pediatrics 15:270, 1955. 27. Potter, E.L.: Pathology of the Fetus and Infant , ed 2, Chicago: Year Book Medical Publishers Inc., 1961. 28. Paradis, A.J., and Roberts, L.: Endogenous Ocular Aspergillosis: Report of a Case in an Infant With Cytomegalic Inclusion Disease , Arch Ophthal 69:765, 1963.Crossref 29. Gitlin, D.; Gross, P.A.M.; and Janeway, C.A.: The Gamma Globulins and Their Clinical Significance , New Eng J Med 260:21, 1959.Crossref 30. Medearis, D.N., Jr.: Cytomegalic Inclusion Disease: An Analysis of the Clinical Features Based on the Literature and Six Additional Cases , Pediatrics 19:467, 1957. 31. Birdsong, M., et al: Generalized Cytomegalic Inclusion Disease in Newborn Infants , JAMA 162:1305, 1956Crossref 32. Bellamy, J.: Cytomegalic Inclusion-Body Disease Occurring in Twins , Amer J Clin Path 24:1040, 1954. 33. Elliott, G.B., and Elliott, K.A.: Observations on Cerebral Cytomegalic Inclusion Disease of the Foetus and Newborn , Arch Dis Child 37:34, 1962.Crossref 34. Akkoyunlu, A., and Yücel, F.A.: Aspergillose bronchopulmonaire et encéphalomeningée chez un nouveau-né de 20 jours , Arch Franc Pediat 14:615, 1957. 35. Luke, J.L.; Bolande, R.P.; and Gross, S.: Generalized Aspergillosis and Aspergillus Endocarditis in Infancy , Pediatrics 31:115, 1963. 36. Cawley, E.P.: Aspergillosis and the Aspergilli: Report of a Unique Case of the Disease , Arch Intern Med 80:423, 1947.Crossref 37. Conen, P.E., et al: Invasive Primary Aspergillosis of the Lung With Cerebral Metastasis and Complete Recovery , Dis Chest 42:88, 1962.Crossref 38. Kozinn, P.J.; Taschdjian, C.L.; and Wiener, H.: Incidence and Pathogenesis of Neonatal Candidiasis , Pediatrics 21:421, 1958. 39. Pappenfort, R.B., Jr., and Schnall, E.S.: Moniliasis in Patients Treated With Aureomycin: Clinical and Laboratory Evidence That Aureomycin Stimulates the Growth of Candida albicans , Arch Intern Med 88:729. 1951.Crossref 40. Moore, M.: In vivo and in Vitro Effect of Aureomycin Hydrochloride on Syringospora (Monilia, Candida) albicans , J Lab Clin Med 37:703, 1951. 41. Huppert, M.; MacPherson, D.A.; and Cazin, J.: Pathogenesis of Candida albicans Infection Following Antibiotic Therapy: 1. The Effect of Antibiotics on the Growth of Candida albicans , J Bact 65:171, 1953. 42. Sharp, J.L.: The Growth of Candida albicans During Antibiotic Therapy , Lancet 1:390, 1954.Crossref 43. McGovern, J.J., et al: The Effect of Aureomycin and Chloramphenicol on the Fungal and Bacterial Flora of Children , New Eng J Med 248:397, 1953.Crossref 44. Gitlin, D., and Craig, J.M.: Thymic Alymphoplasia and Lymphocytic Hypoplasia and Increased Susceptibility to Infection , the Society for Pediatric Research Program and Abstracts, 33rd Annual Meeting, Atlantic City, NJ, (May) 1-2, 1963, p 1. 45. Yakovac, W.C.: Thymic Dysplasia in Congenital A-gammaglobulinemia , the Society for Pediatric Research Program and Abstracts, 33rd Annual Meeting, Atlantic City, NJ, (May) 1-2, 1963, p 2.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1965

References