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Generalized Arteriomegaly: A Possible Predisposition to the Formation of Abdominal Aortic Aneurysms

Generalized Arteriomegaly: A Possible Predisposition to the Formation of Abdominal Aortic Aneurysms Abstract • Studies of patients with arteriomegaly have suggested that an increased incidence of aneurysms occurs in patients with unusually large arteries. However, as far as we know, a study of comparative arterial sites in consecutive patients with aneurysms has not been reported previously. We have compared the diameters of the suprarenal abdominal aortas and iliac arteries in concurrent consecutive series of 12 male patients with aneurysms and 12 male patients with atherosclerotic occlusive disease. These vessels remote from the aneurysms were 40% to 48% larger in diameter in the aneurysmal group by both angiography and direct measurement. In addition, the patients with aneurysms were found to be taller and to have a greater mean body surface area. Possible implications of these findings relevant to the pathogenesis of aneurysms are suggested. (Arch Surg 1981;116:1030-1032) References 1. Leriche R: Dilatation pathologique des artéres en dehors des anéurysmes vie tissulaire des artéres . Presse Med 1942;50:641-642. 2. Leriche R: Dolicho et méga-artére: Dolicho et méga-veine . Presse Med 1943;51:554-555. 3. Thomas L: Arteriomegaly . Br J Surg 1971;58:690-694.Crossref 4. Callum KG, Gaunt JI, Thomas ML, et al: Physiological studies in arteriomegaly . Cardiovasc Res 1974;8:373-383.Crossref 5. Carlson DH, Gryska P, Seletz J, et al: Arteriomegaly . AJR 1975;125:553-558.Crossref 6. Wolinsky H, Glagov S: Comparison of abdominal and thoracic aortic medial structure in mammals: Deviation of man from the usual pattern . Circ Res 1969;25:677-686.Crossref 7. Tilson MD, Stansel HC: Differences in results for aneurysm vs occlusive disease after bifurcation grafts: Results of 100 elective grafts . Arch Surg 1980;115:1173-1175.Crossref 8. Sumner DS, Hokanson DE, Strandness DE: Stress-strain characteristics and collagen-elastin content of abdominal aortic aneurysms . Surg Gynecol Obstet 1970;130:459-466. 9. Busuttil RW, Abou-Zamzam AM, Machleder HI: Collagenase activity of the human aorta: A comparison of patients with and without abdominal aortic aneurysms . Arch Surg 1980;115:1373-1378.Crossref 10. Andrews EJ, White WJ, Bullock LP: Spontaneous aortic aneurysms in Blotchy mice . Am J Pathol 1975;78:199-208. 11. Rowe DW, McGoodwin EB, Martin GR, et al: Decreased lysyl oxidase activity in the aneurysm-prone mottled mouse . J Biol Chem 1977;252:939-942. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Generalized Arteriomegaly: A Possible Predisposition to the Formation of Abdominal Aortic Aneurysms

Archives of Surgery , Volume 116 (8) – Aug 1, 1981

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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1981.01380200038007
Publisher site
See Article on Publisher Site

Abstract

Abstract • Studies of patients with arteriomegaly have suggested that an increased incidence of aneurysms occurs in patients with unusually large arteries. However, as far as we know, a study of comparative arterial sites in consecutive patients with aneurysms has not been reported previously. We have compared the diameters of the suprarenal abdominal aortas and iliac arteries in concurrent consecutive series of 12 male patients with aneurysms and 12 male patients with atherosclerotic occlusive disease. These vessels remote from the aneurysms were 40% to 48% larger in diameter in the aneurysmal group by both angiography and direct measurement. In addition, the patients with aneurysms were found to be taller and to have a greater mean body surface area. Possible implications of these findings relevant to the pathogenesis of aneurysms are suggested. (Arch Surg 1981;116:1030-1032) References 1. Leriche R: Dilatation pathologique des artéres en dehors des anéurysmes vie tissulaire des artéres . Presse Med 1942;50:641-642. 2. Leriche R: Dolicho et méga-artére: Dolicho et méga-veine . Presse Med 1943;51:554-555. 3. Thomas L: Arteriomegaly . Br J Surg 1971;58:690-694.Crossref 4. Callum KG, Gaunt JI, Thomas ML, et al: Physiological studies in arteriomegaly . Cardiovasc Res 1974;8:373-383.Crossref 5. Carlson DH, Gryska P, Seletz J, et al: Arteriomegaly . AJR 1975;125:553-558.Crossref 6. Wolinsky H, Glagov S: Comparison of abdominal and thoracic aortic medial structure in mammals: Deviation of man from the usual pattern . Circ Res 1969;25:677-686.Crossref 7. Tilson MD, Stansel HC: Differences in results for aneurysm vs occlusive disease after bifurcation grafts: Results of 100 elective grafts . Arch Surg 1980;115:1173-1175.Crossref 8. Sumner DS, Hokanson DE, Strandness DE: Stress-strain characteristics and collagen-elastin content of abdominal aortic aneurysms . Surg Gynecol Obstet 1970;130:459-466. 9. Busuttil RW, Abou-Zamzam AM, Machleder HI: Collagenase activity of the human aorta: A comparison of patients with and without abdominal aortic aneurysms . Arch Surg 1980;115:1373-1378.Crossref 10. Andrews EJ, White WJ, Bullock LP: Spontaneous aortic aneurysms in Blotchy mice . Am J Pathol 1975;78:199-208. 11. Rowe DW, McGoodwin EB, Martin GR, et al: Decreased lysyl oxidase activity in the aneurysm-prone mottled mouse . J Biol Chem 1977;252:939-942.

Journal

Archives of SurgeryAmerican Medical Association

Published: Aug 1, 1981

References