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GELATIN SPONGE, A NEW HEMOSTATIC SUBSTANCE: STUDIES ON ABSORBABILITY

GELATIN SPONGE, A NEW HEMOSTATIC SUBSTANCE: STUDIES ON ABSORBABILITY Abstract Hemostasis is a fundamental principle in surgical technic. It can be satisfactorily obtained in most instances by ligature, clips, pressure, electrocoagulation and packs. There are some situations, however, in which venous or capillary bleeding may be difficult to control by these methods. This is especially true of neurosurgical operations in which bleeding from the dura, the brain or the spinal meninges may be especially troublesome. This also obtains in many instances of general surgical procedures, such as operations on liver, kidney, spleen, pancreas, thyroid, bone, chest and female generative tract, in which conventional hemostatic methods may not be adequate. Ways and means of obtaining better hemostasis in such circumstances would constitute a substantial improvement in the general technic of surgery. The major recent advances in the problem of control of capillary and venous oozing have been the development of coagulating agents, such as thrombin, and the use of absorbable substances References 1. Cushing, H.: The Control of Bleeding in Operations for Brain Tumors, with the Description of Silver Clips for the Occlusion of Vessels Inaccessible to the Ligature , Ann. Surg. 54:1, 1911.Crossref 2. Fonio, A.: Ueber die Wirkung der intravenösen und der subkutanen Injektion von Koagulen Kocher-Fonio am Tierversuch, nebst einigen therapeutischen Erfahrungen , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 27:642, 1914. 3. Seegers, W. H.; Warner, E. D.; Brinkhouse, K. M., and Smith, H. P.: The Use of Purified Thrombin as a Hemostatic Agent , Science 89:86, 1939.Crossref 4. Seegers, W. H., and Doub, L.: Oxidized Cellulose and Thrombin , Proc. Soc. Exper. Biol. & Med. 56:72, 1944. 5. Frantz, V. K.: Absorbable Cotton, Paper and Gauze , Ann. Surg. 118:116, 1943. 6. Frantz, V. K.; Clarke, H. T., and Lattes, R.: Hemostasis with Absorbable Gauze , Ann. Surg. 120:181, 1944. 7. Putnam, T. J.: The Use of Thrombin on Soluble Cellulose in Neurosurgery , Ann. Surg. 118:127, 1943. 8. Cronkite, E. P.; Deaver, J. M., and Lozner, E. L.: Experiences with Use of Thrombin With and Without Soluble Cellulose for Local Hemostasis , War Med. 5:80 ( (Feb.) ) 1944. 9. Uihlein, A.; Clagett, O. T.; Osterberg, A. E., and Bennett, W. A.: Absorbable Oxidized Cellulose with Thrombin as a Hemostatic Agent in Surgical Procedures , Surg., Gynec. & Obst. 80:470, 1945. 10. Bering, E. A.: Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation: XX. The Development of Fibrin Foam as a Hemostatic Agent and for Use in Conjunction with Human Thrombin , J. Clin. Investigation 23:586, 1944. 11. Ingraham, F. D., and Bailey, O. T.: The Use of Products Prepared from Human Fibrinogen and Human Thrombin in Neurosurgery: Fibrin Foams as Hemostatic Agents; Fibrin Films in Repair of Dural Defects and in Prevention of Meningocerebral Adhesions , J. Neurosurg. 1:23, 1944. 12. Ingraham, F. D.; Bailey, O. T., and Nulsen, F. E.: Studies on Fibrin Foam as a Hemostatic Agent in Neurosurgery, with Special Reference to Its Comparison with Muscle , J. Neurosurg. 1:171, 1944. 13. Ingraham, F. D., and Bailey, O. T.: Clinical Use of Products of Human Plasma Fractionation: III. The Use of Products of Fibrinogen and Thrombin in Surgery , J. A. M. A. 126:680 ( (Nov. 11) ) 1944. 14. Bailey, O. T., and Ingraham, F. D.: Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation: XXI. The Use of Fibrin Foam as a Hemostatic Agent in Neurosurgery: Clinical and Pathological Studies , J. Clin. Investigation 23:591, 1944. 15. Woodhall, B.: Fibrin Foam as a Hemostatic Agent in Rehabilitation Neurosurgery , J. A. M. A. 126:469 ( (Oct. 21) ) 1944. 16. Correll, J. T., and Wise, E. C.: Certain Properties of a New Physiologically Absorbable Sponge , Proc. Soc. Exper. Biol. & Med. 58:233, 1945. 17. Jenkins, H. P., and Hrdina, L. S.: Absorption of Surgical Gut (Catgut): I. The Decline in Tensile Strength in the Tissues , Arch. Surg. 44:881 ( (May) ) 1942 18. II. Pepsin Digestion Tests for the Evaluation of Duration of Tensile Strength in the Tissues , Hrdina Arch. Surg. 44:984 ( (June) ) 1942. 19. Jenkins, H. P.; Hrdina, L. S.; Owens, F. M., and Swisher, F. M.: Absorption of Surgical Gut (Catgut): III. Duration in the Tissues After Loss of Tensile Strength , Arch. Surg. 45:74 ( (July) ) 1942. 20. Jenkins, H. P.: Absorption of Surgical Gut (Catgut): IV. Recommendations for Absorbability and Digestibility Specifications , Arch. Surg. 45:323 ( (Aug.) ) 1942. 21. Dunham, C. L., and Jenkins, H. P.: Surgical Gut Tubing Fluid as a Tissue Irritant , Ann. Surg. 118:269, 1943.Crossref 22. Jenkins, H. P., and Dunham, C. L.: Irritant Properties of Tubing Fluids as a Factor in the Tissue Reactions Observed with Surgical Gut (Catgut) , Ann. Surg. 118:288, 1943.Crossref 23. Sinclair, J. A., and Douglas, B.: Local Implantation of Gelatin in Wounds , Arch. Surg. 49:47 ( (July) ) 1944.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

GELATIN SPONGE, A NEW HEMOSTATIC SUBSTANCE: STUDIES ON ABSORBABILITY

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References (29)

Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1945.01230040262005
Publisher site
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Abstract

Abstract Hemostasis is a fundamental principle in surgical technic. It can be satisfactorily obtained in most instances by ligature, clips, pressure, electrocoagulation and packs. There are some situations, however, in which venous or capillary bleeding may be difficult to control by these methods. This is especially true of neurosurgical operations in which bleeding from the dura, the brain or the spinal meninges may be especially troublesome. This also obtains in many instances of general surgical procedures, such as operations on liver, kidney, spleen, pancreas, thyroid, bone, chest and female generative tract, in which conventional hemostatic methods may not be adequate. Ways and means of obtaining better hemostasis in such circumstances would constitute a substantial improvement in the general technic of surgery. The major recent advances in the problem of control of capillary and venous oozing have been the development of coagulating agents, such as thrombin, and the use of absorbable substances References 1. Cushing, H.: The Control of Bleeding in Operations for Brain Tumors, with the Description of Silver Clips for the Occlusion of Vessels Inaccessible to the Ligature , Ann. Surg. 54:1, 1911.Crossref 2. Fonio, A.: Ueber die Wirkung der intravenösen und der subkutanen Injektion von Koagulen Kocher-Fonio am Tierversuch, nebst einigen therapeutischen Erfahrungen , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 27:642, 1914. 3. Seegers, W. H.; Warner, E. D.; Brinkhouse, K. M., and Smith, H. P.: The Use of Purified Thrombin as a Hemostatic Agent , Science 89:86, 1939.Crossref 4. Seegers, W. H., and Doub, L.: Oxidized Cellulose and Thrombin , Proc. Soc. Exper. Biol. & Med. 56:72, 1944. 5. Frantz, V. K.: Absorbable Cotton, Paper and Gauze , Ann. Surg. 118:116, 1943. 6. Frantz, V. K.; Clarke, H. T., and Lattes, R.: Hemostasis with Absorbable Gauze , Ann. Surg. 120:181, 1944. 7. Putnam, T. J.: The Use of Thrombin on Soluble Cellulose in Neurosurgery , Ann. Surg. 118:127, 1943. 8. Cronkite, E. P.; Deaver, J. M., and Lozner, E. L.: Experiences with Use of Thrombin With and Without Soluble Cellulose for Local Hemostasis , War Med. 5:80 ( (Feb.) ) 1944. 9. Uihlein, A.; Clagett, O. T.; Osterberg, A. E., and Bennett, W. A.: Absorbable Oxidized Cellulose with Thrombin as a Hemostatic Agent in Surgical Procedures , Surg., Gynec. & Obst. 80:470, 1945. 10. Bering, E. A.: Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation: XX. The Development of Fibrin Foam as a Hemostatic Agent and for Use in Conjunction with Human Thrombin , J. Clin. Investigation 23:586, 1944. 11. Ingraham, F. D., and Bailey, O. T.: The Use of Products Prepared from Human Fibrinogen and Human Thrombin in Neurosurgery: Fibrin Foams as Hemostatic Agents; Fibrin Films in Repair of Dural Defects and in Prevention of Meningocerebral Adhesions , J. Neurosurg. 1:23, 1944. 12. Ingraham, F. D.; Bailey, O. T., and Nulsen, F. E.: Studies on Fibrin Foam as a Hemostatic Agent in Neurosurgery, with Special Reference to Its Comparison with Muscle , J. Neurosurg. 1:171, 1944. 13. Ingraham, F. D., and Bailey, O. T.: Clinical Use of Products of Human Plasma Fractionation: III. The Use of Products of Fibrinogen and Thrombin in Surgery , J. A. M. A. 126:680 ( (Nov. 11) ) 1944. 14. Bailey, O. T., and Ingraham, F. D.: Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation: XXI. The Use of Fibrin Foam as a Hemostatic Agent in Neurosurgery: Clinical and Pathological Studies , J. Clin. Investigation 23:591, 1944. 15. Woodhall, B.: Fibrin Foam as a Hemostatic Agent in Rehabilitation Neurosurgery , J. A. M. A. 126:469 ( (Oct. 21) ) 1944. 16. Correll, J. T., and Wise, E. C.: Certain Properties of a New Physiologically Absorbable Sponge , Proc. Soc. Exper. Biol. & Med. 58:233, 1945. 17. Jenkins, H. P., and Hrdina, L. S.: Absorption of Surgical Gut (Catgut): I. The Decline in Tensile Strength in the Tissues , Arch. Surg. 44:881 ( (May) ) 1942 18. II. Pepsin Digestion Tests for the Evaluation of Duration of Tensile Strength in the Tissues , Hrdina Arch. Surg. 44:984 ( (June) ) 1942. 19. Jenkins, H. P.; Hrdina, L. S.; Owens, F. M., and Swisher, F. M.: Absorption of Surgical Gut (Catgut): III. Duration in the Tissues After Loss of Tensile Strength , Arch. Surg. 45:74 ( (July) ) 1942. 20. Jenkins, H. P.: Absorption of Surgical Gut (Catgut): IV. Recommendations for Absorbability and Digestibility Specifications , Arch. Surg. 45:323 ( (Aug.) ) 1942. 21. Dunham, C. L., and Jenkins, H. P.: Surgical Gut Tubing Fluid as a Tissue Irritant , Ann. Surg. 118:269, 1943.Crossref 22. Jenkins, H. P., and Dunham, C. L.: Irritant Properties of Tubing Fluids as a Factor in the Tissue Reactions Observed with Surgical Gut (Catgut) , Ann. Surg. 118:288, 1943.Crossref 23. Sinclair, J. A., and Douglas, B.: Local Implantation of Gelatin in Wounds , Arch. Surg. 49:47 ( (July) ) 1944.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Nov 1, 1945

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