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GAUDETE!

GAUDETE! Abstract During my senior year in medical school, I had to write and deliver a paper to an undergraduate medical society. After much thought, I chose cystic fibrosis as my topic. It was a "hot disease." Although undoubtedly sickening and killing people or millennia, cystic fibrosis had been recognized1 a mere decade previously. Investigators in New York and Boston had sharply differing views on the pathogenesis of its pulmonary anifestations. Andersen and Hodges2 at Columbia University felt strongly that vitamin A played a key role, whereas Farber3 at Harvard University had coined the term mucoviscidosis to describe what he believed was an inborn disease of all mucus-secreting glands. In preparing my paper I was able to read the entire world's literature on the subject, and for a brief heady moment knew everything that had been published about the disease. (I have been falling farther and farther behind since then.) As boring as that paper was, in retrospect it was crucial in my pediatric References 1. Fanconi G, Uehlinger E, Knauer C. Das Coeliakiesyndrom bei angeborener zystischer Pankreasfibromatose und Bronchiektasien . Wien Med Wochenschr . 1936;86:753-756. 2. Andersen DH, Hodges RG. Celiac syndrome, V: genetics of cystic fibrosis of the pancreas with a consideration of etiology . AJDC . 1946;72:62-80. 3. Farber S. Pancreatic function and disease in early life, V: pathologic changes associated with pancreatic insufficiency in early life . Arch Pathol Lab Med . 1944;37:238-250. 4. Rommens JM, Iannuzzi MC, Kerem B-S, et al. Identification of the cystic fibrosis gene: chromosome walking and jumping . Science . 1989;245:1059-1065.Crossref 5. Yankaskas JR, Knowles MR, Gatzy JT, Boucher RC. Persistence of abnormal chloride ion permeability in cystic fibrosis nasal epithelial cells in heterologous culture . Lancet . 1985;1:954-956.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

GAUDETE!

Abstract

Abstract During my senior year in medical school, I had to write and deliver a paper to an undergraduate medical society. After much thought, I chose cystic fibrosis as my topic. It was a "hot disease." Although undoubtedly sickening and killing people or millennia, cystic fibrosis had been recognized1 a mere decade previously. Investigators in New York and Boston had sharply differing views on the pathogenesis of its pulmonary anifestations. Andersen and Hodges2 at Columbia...
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Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1990.02150270033020
Publisher site
See Article on Publisher Site

Abstract

Abstract During my senior year in medical school, I had to write and deliver a paper to an undergraduate medical society. After much thought, I chose cystic fibrosis as my topic. It was a "hot disease." Although undoubtedly sickening and killing people or millennia, cystic fibrosis had been recognized1 a mere decade previously. Investigators in New York and Boston had sharply differing views on the pathogenesis of its pulmonary anifestations. Andersen and Hodges2 at Columbia University felt strongly that vitamin A played a key role, whereas Farber3 at Harvard University had coined the term mucoviscidosis to describe what he believed was an inborn disease of all mucus-secreting glands. In preparing my paper I was able to read the entire world's literature on the subject, and for a brief heady moment knew everything that had been published about the disease. (I have been falling farther and farther behind since then.) As boring as that paper was, in retrospect it was crucial in my pediatric References 1. Fanconi G, Uehlinger E, Knauer C. Das Coeliakiesyndrom bei angeborener zystischer Pankreasfibromatose und Bronchiektasien . Wien Med Wochenschr . 1936;86:753-756. 2. Andersen DH, Hodges RG. Celiac syndrome, V: genetics of cystic fibrosis of the pancreas with a consideration of etiology . AJDC . 1946;72:62-80. 3. Farber S. Pancreatic function and disease in early life, V: pathologic changes associated with pancreatic insufficiency in early life . Arch Pathol Lab Med . 1944;37:238-250. 4. Rommens JM, Iannuzzi MC, Kerem B-S, et al. Identification of the cystic fibrosis gene: chromosome walking and jumping . Science . 1989;245:1059-1065.Crossref 5. Yankaskas JR, Knowles MR, Gatzy JT, Boucher RC. Persistence of abnormal chloride ion permeability in cystic fibrosis nasal epithelial cells in heterologous culture . Lancet . 1985;1:954-956.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1990

References