Abstract The physiological mechanisms responsible for initiating gastrin release have assumed considerable interest because of their implication in peptic ulcer disease. That a mechanical factor might play an important role in the stimulation of the gastric phase is deduced from the reports by Grossman et al,1 Dragstedt et al,2 and Grossman and Woodward.3 In 1964, Justin-Besançon et al4,5 studied the effect of metoclopramide hydrochloride on the autonomic nervous system, as well as its stimulating action on the gastrointestinal motor activity in man and experimental animals. These studies did not reveal a general parasympathomimetic activity attributable to the compound referred to. Jacoby and Brodie6 showed that metoclopramide accelerated gastric emptying in rats and monkeys and that it stimulated stomach contractile activity in dogs. No significant increase in gastric acid secretion could be demonstrated in rats or dogs. The gastric motor stimulation brought about by matoclopramide was not References 1. Grossman, M.I.; Robertson, C.R.; and Ivy, A.C.: Proof of Hormonal Mechanism for Gastric Secretion: Humoral Transmission of Distention Stimulus , Amer J Physiol 153:1-9 ( (April) ) 1948. 2. Dragstedt, L.R., et al: Antrum Motility as a Stimulus for Gastric Secretion , Gastroenterology 24:71-78, 1953. 3. Grossman, M.I., and Woodward, E.R.: Gastric Distention as Stimulus of Acid Secretion in Human Subjects, 20th International Physiological Congress, Abstracts of Communications , Brussels, 1956, pp 372-373. 4. Justin-Besançon, L., and Laville, C.: Action du métoclopramide sur le système nerveux autonome , C R Soc Biol 158:1016-1018, 1964. 5. Justin-Besançon, L.; Grivaux, M.; and Wattez, E.: L'épreuve au métoclopramide en radiologie digestive , Bull Soc Med Hop Paris 115:721-726, 1964. 6. Jacoby, H.I., and Brodie, D.A.: Gastrointestinal Actions of Metoclopramide: An Experimental Study , Gastroenterology 52: 676-684 ( (April) ) 1967. 7. Ross, B., and Kay, A.W.: The Insulin Test After Vagotomy , Gastroenterology 46: 379-386 ( (April) ) 1964. 8. Oberhelman, H.A., Jr.: The Function of the Gastric Antrum , Surg Clin N Amer 46:269-279 ( (April) ) 1966. 9. De la Rosa, C.; Woodward, E.R.; and Dragstedt, L.R.: Localization of the Gastrin Production Cell , Surg Forum 16:327-329 ( (Oct) ) 1965.
Archives of Surgery – American Medical Association
Published: Oct 1, 1969