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GARGOYLISM AND MORQUIO'S DISEASE

GARGOYLISM AND MORQUIO'S DISEASE AMONG the constitutional disturbances of enchondral bone growth, one must distinguish between disturbances visible at birth (depending on impairment of cartilaginous growth, such as achondroplasia and dyschondroplasia) and the progressive disturbances appearing after birth, in which the enchondral ossification is primarily impaired. Whereas today the former group is well defined, the latter still presents many difficulties both in classification and in diagnosis in single cases. Recently, Cocchi1 made a survey of more than 300 cases and separated them into three distinct categories: (1) dominantly inherited multiple enchondral dysostosis without cloudy corneae (Leri type), (2) recessively inherited multiple enchondral dysostosis without cloudy corneae (Morquio type), and (3) recessively inherited multiple enchondrial dysostosis with cloudy corneae (Hurler type). It is not always easy to establish the line of inheritance in every case, since quite a number of cases have been reported in which the condition appeared in members of otherwise normal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1952.02050040029003
Publisher site
See Article on Publisher Site

Abstract

AMONG the constitutional disturbances of enchondral bone growth, one must distinguish between disturbances visible at birth (depending on impairment of cartilaginous growth, such as achondroplasia and dyschondroplasia) and the progressive disturbances appearing after birth, in which the enchondral ossification is primarily impaired. Whereas today the former group is well defined, the latter still presents many difficulties both in classification and in diagnosis in single cases. Recently, Cocchi1 made a survey of more than 300 cases and separated them into three distinct categories: (1) dominantly inherited multiple enchondral dysostosis without cloudy corneae (Leri type), (2) recessively inherited multiple enchondral dysostosis without cloudy corneae (Morquio type), and (3) recessively inherited multiple enchondrial dysostosis with cloudy corneae (Hurler type). It is not always easy to establish the line of inheritance in every case, since quite a number of cases have been reported in which the condition appeared in members of otherwise normal

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Oct 1, 1952

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