Abstract Ganglioneuromas comprise an infrequent neural tumor characterized histologically by the presence of mature ganglion cells, nerve fibers, and neural supporting tissue. They are generally slow growing, nonmetastasizing, and are generally assumed to derive from sympathetic nerve tissue. Thus they have been found most frequently in the posterior mediastinum and retroperitoneal regions. The only cases of which we are aware that would concern ophthalmology are a single instance of ganglioneuroma in the lacrimal gland,1 a single case in the lid,2 and possibly 2 cases (histologically unproved) occurring in the orbit.3,4 One other case, reported as a ganglioneuroma of the retina5 appears to us to have been an artifactual fold of the retina. The following is believed, therefore, to be a unique case of a ganglioneuroma in the optic chiasm and optic nerves. Report of Case At the time of her first hospital admission the patient was a References 1. Phosphotungstic acid hematoxylin. 2. Wilson, R. P.: Tenth Annual Report of the Memorial Ophthalmic Laboratory , Giza, Cairo, 1935. 3. Krauss, W.: Über eine noch nicht am Augenlid beobachtete Geschwulst: Ganglioneuroma , Z. Augenheilk. 28:110, 1912. 4. Wright, R. E., and Nayar, K. K.: Selected Pictures of Extraocular Affections, from the Museum of the Government Ophthalmic Hospital (Madras) , Madras, Government Press, 1938. 5. Walsh, F. B.: Clinical Neuro-Ophthalmology , Ed. 2, Baltimore, Williams & Wilkins Company, 1957. 6. McCrea, W. B. E.: A Case of Ganglioneuroma of the Retina , Trans. Ophthal. Soc. U.K. 72:235, 1952.
Archives of Ophthalmology – American Medical Association
Published: Apr 1, 1961