Abstract Bruton1 reported that decreased serum γ-globulin may accompany susceptibility to infection. It is, therefore, important to consider dysgammaglobulinemia, hypogammaglobulinemia, and agammaglobulinemia in patients presenting acute and chronic infectious dermatoses. γ-Globulin serum levels have been extensively documented for many dermatologic entities, generally representing the acute infectious and severe varieties. The chronic dermatoses, in which staphylococcic diathesis is an important feature, have received less attention. The purpose of this study is to (1) determine whether the sera of patients with chronic staphylococcic dermatoses have a lowered antibacterial titer, (2) to determine whether the serum γ-globulin levels are reduced, and (3) to observe the response of these dermatoses to γ-globulin therapy. Investigational Methods Three general methods were used during this investigation. A. Clinical Classification of Chronic Staphylococcic Dermatoses and Response to γ-Globulin Therapy.—The chronic staphylococcic dermatoses are divided into diagnostic groups for a more References 1. Bruton, O. C.: Agammaglobulinemia , Pediatrics 9:722 ( (June) ) 1952. 2. Wood, D. C.; Ono, J., and Bessey, H. J.: Serum Antibacterial Activity Measured with a Warburg Apparatus , Lab. Invest. 7:175-180 ( (March) -April) 1958. 3. Barrett, B., and Volwiler, W.: Agamaglobulinemia and Hypogammaglobulinemia—The First 5 Years: J. A. M. A. 164:866-870 ( (June 22) ) 1957.Crossref 4. Mazzitello, W. F., and Good, R. A.: The Clinical Problem of Agammaglobulinemia , Postgrad. Med. 20:95-102 ( (Aug.) ) 1956. 5. Key, M. M., and Nelson, C. T.: Exfoliative Dermatitis Associated with Hypogammaglobulinemia , A. M. A. Arch. Dermat. 74:333-337 ( (Oct.) ) 1956.Crossref 6. Jacox, R. F.: The Activating Effect of Calcium on a Bacterial Substance for Bacillus Subtilis in Human Serum , J. Exper. Med. 92:101-111 ( (Aug.) ) 1950.Crossref 7. Wood, D. C.: Antibacterial Activity of Serum from Patients Showing Hyper- and Hypo-Gamma Globulinemia , Fed. Proc. 16:378 ( (March) ) 1957. 8. Skarnes, R. C., and Watson, D. W.: Antimicrobial Factors of Normal Tissue and Fluids , Bact. Rev. 21:273-294 ( (Dec.) ) 1957. 9. Seltzer, G.; Baron, S., and Toperck, M.: Idiopathic Hypogammaglobulinemia and Agammaglobulinemia , New England J. Med. 252:252-255 ( (Feb. 17) ) 1955.Crossref 10. Schaffer, L. W.; Schwimmer, B. and Staricco, R. J.: The Effect of Gamma Globulin in Pustular Acne , J. Invest. Dermat. 30:97-98 ( (March) ) 1958. 11. Owings, W. J. B.: Hypersensitivity to Gamma Globulin: J. M. A. Alabama 23:74-75 ( (Sept.) ) 1953. 12. Murray, R., and Ratner, F.: Safety of Immune Serum Globulin in Respect to Homologous Serum Hepatitis , Proc. Soc. Exper. Biol. & Med. 83:554-555 ( (July) ) 1953. 13. Pillemer, L. et al: The Properdin System and Immunity: I Demonstration and Isolation of a New Serum Protein, Properdin, and Its Role in Immune Phenomena , Science 120:279-285 ( (Aug.) ) 1954. 14. Deutsch, H. F. et al.: Biophysical Studies of Blood Plasma Proteins: III. Recovery of Gamma Globulin from Human Blood Protein Mixtures , J. Biol. Chem. , 164:109-118 1940.
A.M.A. Archives of Dermatology – American Medical Association
Published: Mar 1, 1959