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Gadolinium Deposition in the Pediatric Brain—Reply

Gadolinium Deposition in the Pediatric Brain—Reply Letters for better understanding both the mechanism and clinical se- Gadolinium Deposition in the Pediatric Brain quelae of gadolinium deposition. However, it is also crucial to To the Editor We read with interest the Research Letter of point out that GBCAs have revolutionized magnetic resonance McDonald et al describing the deposition of gadolinium within imaging examination and diagnostic medicine, often permitting the brains of 3 pediatric patients following the administra- identification of disease that would otherwise go undetected tion of the gadolinium-based contrast agent gadodiamide. The using other imaging modalities. Future risk-benefit assessments gadolinium levels detected within the brain tissue of these of GBCA must balance the currently unproven harm of low lev- decedents ranged from 0.1 to 3.0 μg/g. els of central nervous system gadolinium accumulation with the We have previously published a case report of a pediatric fact that GBCA-enhanced magnetic resonance imaging exami- patient, aged 17 years at time of death, who had undergone 4 nations have helped millions of patients worldwide by provid- gadolinium-enhanced magnetic resonance imaging scans. ing faster and more accurate diagnostic information. Tissue analysis by inductively coupled plasma mass spectro- metry demonstrated 1.01 μg/g of gadolinium within the den- Jennifer S. McDonald, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Gadolinium Deposition in the Pediatric Brain—Reply

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Gadolinium Deposition in the Pediatric Brain—Reply

Abstract

Letters for better understanding both the mechanism and clinical se- Gadolinium Deposition in the Pediatric Brain quelae of gadolinium deposition. However, it is also crucial to To the Editor We read with interest the Research Letter of point out that GBCAs have revolutionized magnetic resonance McDonald et al describing the deposition of gadolinium within imaging examination and diagnostic medicine, often permitting the brains of 3 pediatric patients following the administra- identification...
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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2017.3556
Publisher site
See Article on Publisher Site

Abstract

Letters for better understanding both the mechanism and clinical se- Gadolinium Deposition in the Pediatric Brain quelae of gadolinium deposition. However, it is also crucial to To the Editor We read with interest the Research Letter of point out that GBCAs have revolutionized magnetic resonance McDonald et al describing the deposition of gadolinium within imaging examination and diagnostic medicine, often permitting the brains of 3 pediatric patients following the administra- identification of disease that would otherwise go undetected tion of the gadolinium-based contrast agent gadodiamide. The using other imaging modalities. Future risk-benefit assessments gadolinium levels detected within the brain tissue of these of GBCA must balance the currently unproven harm of low lev- decedents ranged from 0.1 to 3.0 μg/g. els of central nervous system gadolinium accumulation with the We have previously published a case report of a pediatric fact that GBCA-enhanced magnetic resonance imaging exami- patient, aged 17 years at time of death, who had undergone 4 nations have helped millions of patients worldwide by provid- gadolinium-enhanced magnetic resonance imaging scans. ing faster and more accurate diagnostic information. Tissue analysis by inductively coupled plasma mass spectro- metry demonstrated 1.01 μg/g of gadolinium within the den- Jennifer S. McDonald,

Journal

JAMA Pediatrics – American Medical Association

Published: Dec 9, 2017

References

  • Gadolinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy
    Kanda, T; Fukusato, T; Matsuda, M
  • Intracranial gadolinium deposition after contrast-enhanced MR imaging
    McDonald, RJ; McDonald, JS; Kallmes, DF
  • Intracranial gadolinium deposition following contrast enhanced MRI in adult patients with normal brain pathology [published online June 27, 2017]
    McDonald, RJ; McDonald, JS; Kallmes, DF
  • Macrocyclic and other non-group 1 gadolinium contrast agents deposit low levels of gadolinium in brain and bone tissue: preliminary results from 9 patients with normal renal function
    Murata, N; Gonzalez-Cuyar, LF; Murata, K
  • Intracranial gadolinium deposition following gadodiamide-enhanced magnetic resonance imaging in pediatric patients: a case-control study
    McDonald, JS; McDonald, RJ; Jentoft, ME

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