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Future Prospects for PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Patients With Sarcomas

Future Prospects for PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in... Letters 2. Huang CC, Kong MX, Zhou M, et al. Gleason score 3 + 4=7 prostate cancer Antonio Macciò, MD with minimal quantity of Gleason pattern 4 on needle biopsy is associated with Clelia Madeddu, MD low-risk tumor in radical prostatectomy specimen. Am J Surg Pathol. 2014;38 (8):1096-1101. Author Affiliations: Department of Gynecologic Oncology, Azienda Ospedaliera Brotzu, Cagliari, Italy (Macciò); Department of Medical Sciences Future Prospects for PD-1 Targeting, Macrophage and Public Health, University of Cagliari, Cagliari, Italy (Madeddu). Infiltration, and IDO Pathway Activation in Patients Corresponding Author: Antonio Macciò, MD, Department of Gynecologic Oncology, Azienda Ospedaliera Brotzu, via Jenner, Cagliari 09100, Italy With Sarcomas (antoniomaccio56@gmail.com). To the Editor We read with interest the article by Toulmonde and Published Online: June 14, 2018. doi:10.1001/jamaoncol.2018.0875 colleagues assessing the efficacy and safety of anti–programmed Conflict of Interest Disclosures: None reported. cell death protein 1 (PD-1) antibody and metronomic cyclo- 1. Toulmonde M, Penel N, Adam J, et al. Use of PD-1 targeting, macrophage phosphamide in patients with advanced soft-tissue sarcomas. infiltration, and IDO pathway activation in sarcomas: a phase 2 clinical trial. JAMA Oncol. 2018;4(1):93-97. We found the rationale of this combination approach interest- 2. Macciò A, Lai P, Santona MC, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Oncology American Medical Association

Future Prospects for PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Patients With Sarcomas

JAMA Oncology , Volume 4 (8) – Aug 14, 2018

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2374-2437
eISSN
2374-2445
DOI
10.1001/jamaoncol.2018.0875
Publisher site
See Article on Publisher Site

Abstract

Letters 2. Huang CC, Kong MX, Zhou M, et al. Gleason score 3 + 4=7 prostate cancer Antonio Macciò, MD with minimal quantity of Gleason pattern 4 on needle biopsy is associated with Clelia Madeddu, MD low-risk tumor in radical prostatectomy specimen. Am J Surg Pathol. 2014;38 (8):1096-1101. Author Affiliations: Department of Gynecologic Oncology, Azienda Ospedaliera Brotzu, Cagliari, Italy (Macciò); Department of Medical Sciences Future Prospects for PD-1 Targeting, Macrophage and Public Health, University of Cagliari, Cagliari, Italy (Madeddu). Infiltration, and IDO Pathway Activation in Patients Corresponding Author: Antonio Macciò, MD, Department of Gynecologic Oncology, Azienda Ospedaliera Brotzu, via Jenner, Cagliari 09100, Italy With Sarcomas (antoniomaccio56@gmail.com). To the Editor We read with interest the article by Toulmonde and Published Online: June 14, 2018. doi:10.1001/jamaoncol.2018.0875 colleagues assessing the efficacy and safety of anti–programmed Conflict of Interest Disclosures: None reported. cell death protein 1 (PD-1) antibody and metronomic cyclo- 1. Toulmonde M, Penel N, Adam J, et al. Use of PD-1 targeting, macrophage phosphamide in patients with advanced soft-tissue sarcomas. infiltration, and IDO pathway activation in sarcomas: a phase 2 clinical trial. JAMA Oncol. 2018;4(1):93-97. We found the rationale of this combination approach interest- 2. Macciò A, Lai P, Santona MC,

Journal

JAMA OncologyAmerican Medical Association

Published: Aug 14, 2018

References