Abstract It has been suggested that the pathogenesis of psoriasis may be related to immunological processes.1-3 In a recent study, Aswaq et al. postulated that if autoimmune or allergic mechanisms were operative, the sera of psoriatic patients might contain antibodies directed against their own skin.4 Accordingly, this question was investigated using the highly sensitive passive cutaneous anaphylactic technique to detect any antigen-antibody interaction.5,6 Results of this study indicated that specific, apparently immunologic reactions could be evoked in guinea pigs with serum and plaque tissue provided by patients with psoriasis. In view of these observations, it was speculated that this disease may depend upon an autoimmune process; however, it was clearly stated that the available data did not provide firm objective evidence for this possibility. In the course of further work on the immunology of psoriasis, results were obtained which conflicted with those reported by Aswaq et al. References 1. Lorincz, A. L.: Observations on the Problem of Pathogenesis in Psoriasis , Ann. N.Y. Acad. Sc. 73:1000-1003, 1958.Crossref 2. Henocq, E., and Guibert, L.: Psoriasis and Dermatitis Originating in Sensitization to Moulds , Concours Med. 80: 4081-4083, 1958. 3. MacKenna, R. M. B.: Aids to Dermatology and Venereal Disease , Ed. 3, London, Baillière, Tindall & Cox, Ltd., 1946, p. 217. 4. Aswaq, M.; Farber, E. M.; Moreci, A. P., and Raffel, S.: Immunologic Reactions in Psoriasis , Arch. Derm. 82:663-666, 1960.Crossref 5. Ovary, Z.: Immediate Reactions in the Skin of Experimental Animals Provoked by Antibody-Antigen Interaction , Progr. Allergy 5:459-508, 1958. 6. Rosenberg, L. T.: Passive Cutaneous Anaphylaxis , Rev. Allergy 12:710-716, 1958. 7. Lovell, R. R. H.; Pryce, D. M., and Boake, W. C.: The Necrotic Lesions in Guinea-Pig Skin Produced by Certain Human Sera , Brit. J. Exp. Path. 35:345-349, 1954. 8. Boake, W. C., and Lovell, R. R. H.: The Necrotizing Activity of Human Sera for Guinea-Pig Skin , Brit. J. Exp. Path. 35: 350-357, 1954.
Archives of Dermatology – American Medical Association
Published: May 1, 1962