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Furosemide, a New Diuretic in Edematous States: Clinical Studies in Patients With Congestive Heart Failure and Cirrhosis of the Liver

Furosemide, a New Diuretic in Edematous States: Clinical Studies in Patients With Congestive... Abstract Furosemide, a new anthranilic acid diuretic, has been studied extensively during the last two to three years.1-4 It has been demonstrated that furosemide is a potent drug with a wide margin of safety and a diuretic response superior to that of hydrochlorothiazide.5,6 This paper reports on the usefulness of this diuretic in the treatment of edematous states secondary to congestive heart failure and cirrhosis of the liver. Materials and Methods Thirty patients with congestive heart failure admitted to the medical ward of the New York Polyclinic Hospital were initially treated with a regimen of complete bed rest, a diet containing 20 mEq of sodium and full digitalization until a steady weight was reached. Twenty-two achieved an edema-free state and were excluded from further study. The remaining eight patients reached a stable weight with this regimen with significant residual fluid retention.Nine patients with advanced cirrhosis of the liver References 1. Schnack, H.: Therapeutische Erfahrungen mit einem neuen Saluretikum , Wien Klin Wschr 76:476, 1964. 2. Robson, A.O., et al: The Diuretic Response to Frusemide , Lancet 2:1085, 1964.Crossref 3. Stokes, W., and Nunn, L.C.A.: A New Effective Diuretic, Lasix , Brit Med J 2:910, 1964.Crossref 4. Muth, R.G.: Diuretic Response to Furosemide in the Presence of Renal Insufficiency , JAMA 195:1066, 1966.Crossref 5. Verel, D., et al: A Clinical Trial of Frusemide , Lancet 2:1088, 1964.Crossref 6. Hutcheon, D.E.; Mehta, D.; and Romano, A.: Diuretic Action of Furosemide , Arch Intern Med 115:542, 1965.Crossref 7. Suzuki, F.; Kluetsch, K.; and Heidland, A.: Stop-flow-Untersuchungen zum Wirkungsmechanismus von Fursemid , Klin Wschr 42:569, 1964.Crossref 8. Suki, W.; Rector, F.C., Jr.; and Seldin, D.W.: The Site of Action of Furosemide and Other Sulfonamide Diuretics in the Dog , J Clin Invest 44:1458, 1965.Crossref 9. Kleinfelder, H.: Experimental Investigations and Clinical Trials of Fursemide, a New Diuretic , German Med Monthly 8:459, 1963. 10. Vorburger, C.: Un nouveau diuretique, le Fursemid , Rev Med Suisse Rom 84:277, 1964. 11. Haussler, A., and Hajdu, P.: Untersuchungen mit dem Salidiureticum 4-Chlor-N-(furylmethyl) -5 sulfamyl-anthranilsaure , Arzneimittelforschung 14:710, 1964. 12. Heidland, A.; Kluetsch, K.; and Suzuki, F.: Nierenhaemodynamik, Wasser und Elektrolytausscheidung nach 4-Chlor-N-(2 furylmethyl)-5 sulfamoyl-antranilsaure , Arzneimittelforschung 14:713, 1964. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Furosemide, a New Diuretic in Edematous States: Clinical Studies in Patients With Congestive Heart Failure and Cirrhosis of the Liver

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00290200113010
Publisher site
See Article on Publisher Site

Abstract

Abstract Furosemide, a new anthranilic acid diuretic, has been studied extensively during the last two to three years.1-4 It has been demonstrated that furosemide is a potent drug with a wide margin of safety and a diuretic response superior to that of hydrochlorothiazide.5,6 This paper reports on the usefulness of this diuretic in the treatment of edematous states secondary to congestive heart failure and cirrhosis of the liver. Materials and Methods Thirty patients with congestive heart failure admitted to the medical ward of the New York Polyclinic Hospital were initially treated with a regimen of complete bed rest, a diet containing 20 mEq of sodium and full digitalization until a steady weight was reached. Twenty-two achieved an edema-free state and were excluded from further study. The remaining eight patients reached a stable weight with this regimen with significant residual fluid retention.Nine patients with advanced cirrhosis of the liver References 1. Schnack, H.: Therapeutische Erfahrungen mit einem neuen Saluretikum , Wien Klin Wschr 76:476, 1964. 2. Robson, A.O., et al: The Diuretic Response to Frusemide , Lancet 2:1085, 1964.Crossref 3. Stokes, W., and Nunn, L.C.A.: A New Effective Diuretic, Lasix , Brit Med J 2:910, 1964.Crossref 4. Muth, R.G.: Diuretic Response to Furosemide in the Presence of Renal Insufficiency , JAMA 195:1066, 1966.Crossref 5. Verel, D., et al: A Clinical Trial of Frusemide , Lancet 2:1088, 1964.Crossref 6. Hutcheon, D.E.; Mehta, D.; and Romano, A.: Diuretic Action of Furosemide , Arch Intern Med 115:542, 1965.Crossref 7. Suzuki, F.; Kluetsch, K.; and Heidland, A.: Stop-flow-Untersuchungen zum Wirkungsmechanismus von Fursemid , Klin Wschr 42:569, 1964.Crossref 8. Suki, W.; Rector, F.C., Jr.; and Seldin, D.W.: The Site of Action of Furosemide and Other Sulfonamide Diuretics in the Dog , J Clin Invest 44:1458, 1965.Crossref 9. Kleinfelder, H.: Experimental Investigations and Clinical Trials of Fursemide, a New Diuretic , German Med Monthly 8:459, 1963. 10. Vorburger, C.: Un nouveau diuretique, le Fursemid , Rev Med Suisse Rom 84:277, 1964. 11. Haussler, A., and Hajdu, P.: Untersuchungen mit dem Salidiureticum 4-Chlor-N-(furylmethyl) -5 sulfamyl-anthranilsaure , Arzneimittelforschung 14:710, 1964. 12. Heidland, A.; Kluetsch, K.; and Suzuki, F.: Nierenhaemodynamik, Wasser und Elektrolytausscheidung nach 4-Chlor-N-(2 furylmethyl)-5 sulfamoyl-antranilsaure , Arzneimittelforschung 14:713, 1964.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1967

References