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FUNGISTATIC AND FUNGICIDAL EFFECTS OF TWO WOOD-PRESERVING CHEMICALS ON HUMAN DERMATOPHYTES: ORTHO (2 CHLOROPHENYL) PHENOL SODIUM AND TETRACHLORPHENOL SODIUM

FUNGISTATIC AND FUNGICIDAL EFFECTS OF TWO WOOD-PRESERVING CHEMICALS ON HUMAN DERMATOPHYTES: ORTHO... Abstract Since the medical profession has taken cognizance of the large and increasing number of dermatoses of fungous origin, interest in their therapy has grown apace, further stimulated by the realization that as yet no highly specific drugs have been developed which yield even reasonably satisfactory results in all proved cases of fungous dermatitis. Continued study of the behavior of various drugs toward pathogenic fungi in the laboratory has served to increase the conviction that many factors other than the specific toxicity demonstrated in the test tube determine the clinical usefulness of a fungicide. Among such factors are included its tolerance by the human skin in concentrations permitting appreciable fungicidal action, its inactivation by various vehicles, the possibility of actual penetration of the chemically active substance to the layers of the epidermis which contain the actively growing organisms and its specificity or lack of toxicity for the species of fungus present. References 1. Hatfield, Ira: Recent Experiments with Chemicals Suggested for Wood Preservation , Proc. Am. Wood Preservers' A . 27:304, 1931. 2. Schmitz, Henry, et al.: A Suggested Toximetric Method for Wood Preservatives , Indust. & Engin. Chem. (Anal. Ed.) 2:361, 1930. 3. Hatfield, Ira: Further Experiments with Chemicals Suggested as Possible Wood Preservatives , Proc. Am. Wood Preservers' A. 28:330, 1932. 4. Lindgren, R. M.; Scheffer, T. C., and Chapman, A. D.: Tests of Chemical Treatments for Control of Sap Stain and Mold in Southern Lumber , Indust. & Engin. Chem. 25:72, 1933. 5. Chapman, A. D., and Scheffer, T. C.: New Chemical Treatment for the Control of Sap Stain and Mold , South. Lumberman , (May 15) , 1933. 6. Leonian, L. H.: Effect of Position of Inoculum on Growth of Some Trichophytons in the Presence of Dyes , Arch. Dermat. & Syph. 25:1016 ( (June) ) 1932. 7. Schamberg, J. F.; Brown, Herman, and Harkins, M. J.: The Chemotherapy of Ringworm Infection , Arch. Dermat. & Syph. 24:1033 ( (Dec.) ) 1931. 8. Emmons, C. W.: Fungicidal Action of Some Common Disinfectants on Two Dermatophytes , Arch. Dermat. & Syph. 28:15 ( (July) ) 1933. 9. Anderson, J. F., and McClintic, T. B.: Method of Standardizing Disinfectants With and Without Organic Materials , U. S. Pub. Health Serv., Hygienic Laboratory Bulletin 82, 1912. 10. Myers, H. B., and Thienes, C. H.: Fungicidal Activity of Certain Oils and Stearoptens: Their Comparative Toxicity on a Pathogenic Yeast-Like Organism , J. A. M. A. 84:1985 ( (June 27) ) 1925. 11. Schamberg, J. F., and Kolmer, J. A.: Studies of the Chemotherapy of Fungus Infections , Arch. Dermat. & Syph. 6:746 ( (Dec.) ) 1922. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

FUNGISTATIC AND FUNGICIDAL EFFECTS OF TWO WOOD-PRESERVING CHEMICALS ON HUMAN DERMATOPHYTES: ORTHO (2 CHLOROPHENYL) PHENOL SODIUM AND TETRACHLORPHENOL SODIUM

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Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1935.01460230031004
Publisher site
See Article on Publisher Site

Abstract

Abstract Since the medical profession has taken cognizance of the large and increasing number of dermatoses of fungous origin, interest in their therapy has grown apace, further stimulated by the realization that as yet no highly specific drugs have been developed which yield even reasonably satisfactory results in all proved cases of fungous dermatitis. Continued study of the behavior of various drugs toward pathogenic fungi in the laboratory has served to increase the conviction that many factors other than the specific toxicity demonstrated in the test tube determine the clinical usefulness of a fungicide. Among such factors are included its tolerance by the human skin in concentrations permitting appreciable fungicidal action, its inactivation by various vehicles, the possibility of actual penetration of the chemically active substance to the layers of the epidermis which contain the actively growing organisms and its specificity or lack of toxicity for the species of fungus present. References 1. Hatfield, Ira: Recent Experiments with Chemicals Suggested for Wood Preservation , Proc. Am. Wood Preservers' A . 27:304, 1931. 2. Schmitz, Henry, et al.: A Suggested Toximetric Method for Wood Preservatives , Indust. & Engin. Chem. (Anal. Ed.) 2:361, 1930. 3. Hatfield, Ira: Further Experiments with Chemicals Suggested as Possible Wood Preservatives , Proc. Am. Wood Preservers' A. 28:330, 1932. 4. Lindgren, R. M.; Scheffer, T. C., and Chapman, A. D.: Tests of Chemical Treatments for Control of Sap Stain and Mold in Southern Lumber , Indust. & Engin. Chem. 25:72, 1933. 5. Chapman, A. D., and Scheffer, T. C.: New Chemical Treatment for the Control of Sap Stain and Mold , South. Lumberman , (May 15) , 1933. 6. Leonian, L. H.: Effect of Position of Inoculum on Growth of Some Trichophytons in the Presence of Dyes , Arch. Dermat. & Syph. 25:1016 ( (June) ) 1932. 7. Schamberg, J. F.; Brown, Herman, and Harkins, M. J.: The Chemotherapy of Ringworm Infection , Arch. Dermat. & Syph. 24:1033 ( (Dec.) ) 1931. 8. Emmons, C. W.: Fungicidal Action of Some Common Disinfectants on Two Dermatophytes , Arch. Dermat. & Syph. 28:15 ( (July) ) 1933. 9. Anderson, J. F., and McClintic, T. B.: Method of Standardizing Disinfectants With and Without Organic Materials , U. S. Pub. Health Serv., Hygienic Laboratory Bulletin 82, 1912. 10. Myers, H. B., and Thienes, C. H.: Fungicidal Activity of Certain Oils and Stearoptens: Their Comparative Toxicity on a Pathogenic Yeast-Like Organism , J. A. M. A. 84:1985 ( (June 27) ) 1925. 11. Schamberg, J. F., and Kolmer, J. A.: Studies of the Chemotherapy of Fungus Infections , Arch. Dermat. & Syph. 6:746 ( (Dec.) ) 1922.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: May 1, 1935

References