CLINICAL SCIENCES Fundus Autofluorescence in Autosomal Dominant Occult Macular Dystrophy Kaoru Fujinami, MD; Kazushige Tsunoda, MD, PhD; Gen Hanazono, MD; Kei Shinoda, MD, PhD; Hisao Ohde, MD, PhD; Yozo Miyake, MD, PhD Objective: To characterize fundus autofluorescence fovea bilaterally. The optical coherence tomographic im- (FAF) images of eyes with autosomal dominant occult ages showed abnormalities of the photoreceptor inner seg- macular dystrophy (OMD). ment–outer segment line and cone outer segment tip line in all patients. However, 5 patients had normal FAF im- Methods: All patients received a comprehensive oph- ages regardless of morphological abnormalities of the pho- thalmologic examination for diagnosis of OMD. We evalu- toreceptor. ated the FAF images in 13 eyes of 7 patients with auto- somal dominant OMD by confocal scanning laser Conclusions: Fundus autofluorescence is a useful method ophthalmoscopy with excitation at 488 nm and emis- to acquire additional information of photoreceptor/ sion more than 500 nm. retinal pigment epithelium function in eyes with OMD. Fundus autofluorescence will be also helpful for the dif- Results: The FAF images showed unspecific weak fo- ferential diagnosis of eyes with OMD vs eyes with other veal hyperfluorescence in 4 eyes of 2 patients; one showed dystrophies that have
JAMA Ophthalmology – American Medical Association
Published: May 1, 2011
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