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Functioning Islet-Cell Adenoma of the Pancreas

Functioning Islet-Cell Adenoma of the Pancreas Abstract Langerhans in 1869 first described the pancreatic islets. Fifty-five years later came the monumental discovery of insulin by Banting and Best. Three years later, in 1927, Wilder and his associates6 reported the first case of hyperinsulinism associated with an islet-cell adenoma. Roscoe Graham in 1929 performed the first recorded surgical cure of this disease. In 1950 Howard, Moss, and Rhoads4 analyzed 224 operative cases collected from the world's literature. Conn and Seltzer3 in 1955 presented an excellent review and etiologic classification of spontaneous hypoglycemia—organic and functional. Our report presents an additional interesting case of functioning islet-cell adenoma and emphasizes some important clinical and technical points in the surgery of this tumor. The patient was a 29-year-old white housewife admitted to the Albert Einstein Medical Center, Southern Division, on July 25, 1958, complaining of "fainting spells" three months prior to admission. The first "attack" preceded breakfast after arising, References 1. Breidahl, H. D.; Priestley, J. T., and Rynearson, E. H.: Hyperinsulinism: Surgical Aspects and Results , Ann. Surg. 142:698-708 ( (Oct.) ) 1955.Crossref 2. Cohen, A. S.; Senter, K., and Vance, V. K.: Islet-Cell Adenoma: Report of a Case with a Brief Review of Diagnostic Criteria , A.M.A. Arch. Surg. 73:801-803 ( (Nov.) ) 1956.Crossref 3. Conn, J. W., and Seltzer, H. S.: Spontaneous Hypoglycemia , Am. J. Med. 19:460-478 ( (Sept.) ) 1955.Crossref 4. Howard, J. M.; Moss, N. H., and Rhoads, J. E.: Collective Review: Hyperinsulinism and Islet Cell Tumors of the Pancreas , Surg. Gynec. & Obst. 90:417-455 ( (May) ) 1950. 5. Wilder, R. M.: Clinical Diabetes Mellitus and Hyperinsulinism , Philadelphia, W. B. Saunders Company, 1940. 6. Wilder, R. M.; Allan, F. N.; Power, M. H., and Robertson, H. E.: Carcinoma of the Islands of the Pancreas. Hyperinsulinism and Hypoglycemia , J.A.M.A. 89:348-355 ( (July 30) ) 1927. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Functioning Islet-Cell Adenoma of the Pancreas

Archives of Surgery , Volume 81 (1) – Jul 1, 1960

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1960.01300010052007
Publisher site
See Article on Publisher Site

Abstract

Abstract Langerhans in 1869 first described the pancreatic islets. Fifty-five years later came the monumental discovery of insulin by Banting and Best. Three years later, in 1927, Wilder and his associates6 reported the first case of hyperinsulinism associated with an islet-cell adenoma. Roscoe Graham in 1929 performed the first recorded surgical cure of this disease. In 1950 Howard, Moss, and Rhoads4 analyzed 224 operative cases collected from the world's literature. Conn and Seltzer3 in 1955 presented an excellent review and etiologic classification of spontaneous hypoglycemia—organic and functional. Our report presents an additional interesting case of functioning islet-cell adenoma and emphasizes some important clinical and technical points in the surgery of this tumor. The patient was a 29-year-old white housewife admitted to the Albert Einstein Medical Center, Southern Division, on July 25, 1958, complaining of "fainting spells" three months prior to admission. The first "attack" preceded breakfast after arising, References 1. Breidahl, H. D.; Priestley, J. T., and Rynearson, E. H.: Hyperinsulinism: Surgical Aspects and Results , Ann. Surg. 142:698-708 ( (Oct.) ) 1955.Crossref 2. Cohen, A. S.; Senter, K., and Vance, V. K.: Islet-Cell Adenoma: Report of a Case with a Brief Review of Diagnostic Criteria , A.M.A. Arch. Surg. 73:801-803 ( (Nov.) ) 1956.Crossref 3. Conn, J. W., and Seltzer, H. S.: Spontaneous Hypoglycemia , Am. J. Med. 19:460-478 ( (Sept.) ) 1955.Crossref 4. Howard, J. M.; Moss, N. H., and Rhoads, J. E.: Collective Review: Hyperinsulinism and Islet Cell Tumors of the Pancreas , Surg. Gynec. & Obst. 90:417-455 ( (May) ) 1950. 5. Wilder, R. M.: Clinical Diabetes Mellitus and Hyperinsulinism , Philadelphia, W. B. Saunders Company, 1940. 6. Wilder, R. M.; Allan, F. N.; Power, M. H., and Robertson, H. E.: Carcinoma of the Islands of the Pancreas. Hyperinsulinism and Hypoglycemia , J.A.M.A. 89:348-355 ( (July 30) ) 1927.

Journal

Archives of SurgeryAmerican Medical Association

Published: Jul 1, 1960

References