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Functioning Adenomas of Pancreas With Hyperinsulinism: Report of 13 Patients

Functioning Adenomas of Pancreas With Hyperinsulinism: Report of 13 Patients Abstract FUNCTIONING tumors of the pancreas which produce hypoglycemia continue to pose problems in diagnosis and management. The first successful removal of a functioning adenoma by Roscoe Graham in 192916 had been preceded by the work of Harris13 and Wilder35 which was instrumental in the discovery of this interesting pathophysiologic relationship. Members including Judd,18 Engel,8 Nesselrode,25 and Cheley3 soon reported successful removal of adenomata before this association in 1934. At that same meeting, George Thomason30 reported a patient with symptoms of hyperinsulinism upon whom he had operated and an adenoma was not found. Removal of the tail and body of the pancreas, subsequently found not to contain an adenoma, resulted in improvement for the short three month follow-up. Graham and Hartmann12 had reported a similar result in a 12-month-old child with hyperinsulinism after a 90% resection of the distal pancreas. These and References 1. Camperlengo, H. A.: Pancreatic Islet Cell Adenoma Presenting as Neuropsychiatric Problems , New York J Med 61:3327, 1961. 2. Cattell, R. B., and Warren, K. W.: Surgery of Pancreas , Philadelphia: W. B. Saunders Co., 1953. 3. Cheley, G. E., in discussion.30 4. Cole, W. H.: Surgery of Pancreas , Surg Clin N Amer 24:16, 1944. 5. Crain, E. J., Jr., and Thorn, G. W.: Functioning Pancreatic Islet Cell Adenomas , Medicine 28:427, 1949.Crossref 6. David, V. C.: Indications and Results of Pancreatectomy for Hypoglycemia , Surgery 8:212, 1940. 7. David, V. C., and Campbell, L. K.: Experiences in Subtotal Resection of Pancreas in Hypoglycemia , Ann Surg 123:836, 1946.Crossref 8. Engel, L. P., in discussion.30 9. Fletcher, A. A., and Campbell, W. R.: Blood Sugar Following Insulin Administration and Symptom Complex—Hypoglycemia , J Metab Res 2:637, 1922. 10. Fonkalsrud, E. W.; Dilley, R. B.; and Longmire, W. P., Jr.: Insulin Secreting Tumors of Pancreas , Ann Surg 159:730, 1964.Crossref 11. Frantz, V. K.: Tumors of Pancreas , Washington, DC, Armed Forces Institute of Pathology, 1959. 12. Graham, E. A., and Hartmann, A. F.: Subtotal Resection of Pancreas for Hypoglycemia , Surg Gynec Obstet 59:474, 1934. 13. Harris, S.: Hyperinsulinism and Dysinsulinism , JAMA 83:729, 1924.Crossref 14. Holman, E., and Railsback, O. C.: Partial Pancreatectomy in Chronic Hypoglycemia , Surg Gynec Obstet 56:591, 1933. 15. Howard, J. M.; Moss, N. H.; and Rhoads, J. E.: Collective Review: Hyperinsulinism and Islet Cell Tumors of Pancreas with 398 Recorded Tumors , Int Abstr Surg 90:417, 1950. 16. Howland, G., et al: Dysinsulinism , JAMA 93:674, 1929.Crossref 17. Judd, E. S.; Allan, F. N.; and Rynearson, R. H.: Hyperinsulinism—Its Surgical Treatment , JAMA 101:99, 1933.Crossref 18. Judd, E. S., in discussion.30 19. John, H. G.: Hyperinsulinism , Med Clin N Amer 17:979, 1934. 20. Maxeiner, S. R., and Bundy, H. E.: Islet Cell Tumor of Pancreas , Trans West Surg Assoc 52:236, 1945. 21. Miller, D. R., et al: Hypoglycemia Due to Non-pancreatic Mesodermal Tumors: Report of Two Cases , Ann Surg 150:684, 1959.Crossref 22. Mills, J. R. F.: Islet Cell Tumors of Pancreas , Canad J Surg 3:291, 1960. 23. Monro, R. S.: Islet Cell Tumors of Pancreas With Hypoglycemia , Postgrad Med J 36:160, 1960.Crossref 24. Moss, N. H., and Rhoads, J. E.: " Hyperinsulinism and Islet Cell Tumors of Pancreas ," in Howard, J. M., and Jordan, G. L. (eds.): Surgical Diseases of Pancreas , Philadelphia: J. B. Lippincott Co., 1960. 25. Nesselrode, C. C., in discussion.30 26. Oleary, J. L., and Womack, N.: Histology of Adenoma of Islets of Langerhans , Arch Path 17:291, 1934. 27. Orr, T. G., in discussion of Brown, A.: Trans West Surg Assoc 49:792, 1941. 28. Scott, H. W., Jr., in discussion.10 29. Smith, L. B.; Hashinger, E. H.; and Engel, L. P.: Hyperinsulinism Due to Adenoma of Islets of Langerhans , J Kansas Med Soc 36:363, 1935. 30. Thomason, G.: Hyperinsulism, Hypoglycemia, Subtotal Pancreatectomy , Trans West Surg Assoc 44:85, 1934. 31. Trajans, S. S., et al: Diagnostic Value of Sodium Tolbutamide in Hypoglycemia States , J Clin Endocr 21:371, 1961.Crossref 32. Whipple, A. O.: Hyperinsulinism in Relation to Pancreatic Tumors , Surgery 16:289, 1944. 33. Whipple, A. O., in discussion.7 34. Whipple, A. O.: Surgical Therapy of Hyperinsulinism , J Int Chir 3:237, 1938. 35. Wilder, R. M., et al: Carcinoma of Islands of Pancreas , JAMA 89:348, 1927.Crossref 36. Zollinger, R. M., and Ellison, E.: Primary Peptic Ulcerations of Jejunum Associated With Islet Cell Tumors of Pancreas , Ann Surg 142:709, 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Functioning Adenomas of Pancreas With Hyperinsulinism: Report of 13 Patients

Archives of Surgery , Volume 90 (4) – Apr 1, 1965

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1965.01320100053010
Publisher site
See Article on Publisher Site

Abstract

Abstract FUNCTIONING tumors of the pancreas which produce hypoglycemia continue to pose problems in diagnosis and management. The first successful removal of a functioning adenoma by Roscoe Graham in 192916 had been preceded by the work of Harris13 and Wilder35 which was instrumental in the discovery of this interesting pathophysiologic relationship. Members including Judd,18 Engel,8 Nesselrode,25 and Cheley3 soon reported successful removal of adenomata before this association in 1934. At that same meeting, George Thomason30 reported a patient with symptoms of hyperinsulinism upon whom he had operated and an adenoma was not found. Removal of the tail and body of the pancreas, subsequently found not to contain an adenoma, resulted in improvement for the short three month follow-up. Graham and Hartmann12 had reported a similar result in a 12-month-old child with hyperinsulinism after a 90% resection of the distal pancreas. These and References 1. Camperlengo, H. A.: Pancreatic Islet Cell Adenoma Presenting as Neuropsychiatric Problems , New York J Med 61:3327, 1961. 2. Cattell, R. B., and Warren, K. W.: Surgery of Pancreas , Philadelphia: W. B. Saunders Co., 1953. 3. Cheley, G. E., in discussion.30 4. Cole, W. H.: Surgery of Pancreas , Surg Clin N Amer 24:16, 1944. 5. Crain, E. J., Jr., and Thorn, G. W.: Functioning Pancreatic Islet Cell Adenomas , Medicine 28:427, 1949.Crossref 6. David, V. C.: Indications and Results of Pancreatectomy for Hypoglycemia , Surgery 8:212, 1940. 7. David, V. C., and Campbell, L. K.: Experiences in Subtotal Resection of Pancreas in Hypoglycemia , Ann Surg 123:836, 1946.Crossref 8. Engel, L. P., in discussion.30 9. Fletcher, A. A., and Campbell, W. R.: Blood Sugar Following Insulin Administration and Symptom Complex—Hypoglycemia , J Metab Res 2:637, 1922. 10. Fonkalsrud, E. W.; Dilley, R. B.; and Longmire, W. P., Jr.: Insulin Secreting Tumors of Pancreas , Ann Surg 159:730, 1964.Crossref 11. Frantz, V. K.: Tumors of Pancreas , Washington, DC, Armed Forces Institute of Pathology, 1959. 12. Graham, E. A., and Hartmann, A. F.: Subtotal Resection of Pancreas for Hypoglycemia , Surg Gynec Obstet 59:474, 1934. 13. Harris, S.: Hyperinsulinism and Dysinsulinism , JAMA 83:729, 1924.Crossref 14. Holman, E., and Railsback, O. C.: Partial Pancreatectomy in Chronic Hypoglycemia , Surg Gynec Obstet 56:591, 1933. 15. Howard, J. M.; Moss, N. H.; and Rhoads, J. E.: Collective Review: Hyperinsulinism and Islet Cell Tumors of Pancreas with 398 Recorded Tumors , Int Abstr Surg 90:417, 1950. 16. Howland, G., et al: Dysinsulinism , JAMA 93:674, 1929.Crossref 17. Judd, E. S.; Allan, F. N.; and Rynearson, R. H.: Hyperinsulinism—Its Surgical Treatment , JAMA 101:99, 1933.Crossref 18. Judd, E. S., in discussion.30 19. John, H. G.: Hyperinsulinism , Med Clin N Amer 17:979, 1934. 20. Maxeiner, S. R., and Bundy, H. E.: Islet Cell Tumor of Pancreas , Trans West Surg Assoc 52:236, 1945. 21. Miller, D. R., et al: Hypoglycemia Due to Non-pancreatic Mesodermal Tumors: Report of Two Cases , Ann Surg 150:684, 1959.Crossref 22. Mills, J. R. F.: Islet Cell Tumors of Pancreas , Canad J Surg 3:291, 1960. 23. Monro, R. S.: Islet Cell Tumors of Pancreas With Hypoglycemia , Postgrad Med J 36:160, 1960.Crossref 24. Moss, N. H., and Rhoads, J. E.: " Hyperinsulinism and Islet Cell Tumors of Pancreas ," in Howard, J. M., and Jordan, G. L. (eds.): Surgical Diseases of Pancreas , Philadelphia: J. B. Lippincott Co., 1960. 25. Nesselrode, C. C., in discussion.30 26. Oleary, J. L., and Womack, N.: Histology of Adenoma of Islets of Langerhans , Arch Path 17:291, 1934. 27. Orr, T. G., in discussion of Brown, A.: Trans West Surg Assoc 49:792, 1941. 28. Scott, H. W., Jr., in discussion.10 29. Smith, L. B.; Hashinger, E. H.; and Engel, L. P.: Hyperinsulinism Due to Adenoma of Islets of Langerhans , J Kansas Med Soc 36:363, 1935. 30. Thomason, G.: Hyperinsulism, Hypoglycemia, Subtotal Pancreatectomy , Trans West Surg Assoc 44:85, 1934. 31. Trajans, S. S., et al: Diagnostic Value of Sodium Tolbutamide in Hypoglycemia States , J Clin Endocr 21:371, 1961.Crossref 32. Whipple, A. O.: Hyperinsulinism in Relation to Pancreatic Tumors , Surgery 16:289, 1944. 33. Whipple, A. O., in discussion.7 34. Whipple, A. O.: Surgical Therapy of Hyperinsulinism , J Int Chir 3:237, 1938. 35. Wilder, R. M., et al: Carcinoma of Islands of Pancreas , JAMA 89:348, 1927.Crossref 36. Zollinger, R. M., and Ellison, E.: Primary Peptic Ulcerations of Jejunum Associated With Islet Cell Tumors of Pancreas , Ann Surg 142:709, 1955.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Apr 1, 1965

References