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FUNCTION RECOVERY PATTERN IN ACUTE RENAL FAILURE FOLLOWING INGESTION OF MERCURIC CHLORIDE

FUNCTION RECOVERY PATTERN IN ACUTE RENAL FAILURE FOLLOWING INGESTION OF MERCURIC CHLORIDE THE CHARACTERISTIC renal lesion produced by mercuric chloride has been described as being confined largely to the proximal tubule.1 Large doses of mercury tend to produce necrosis extending the whole length of the proximal tubule from the glomerulus to the descending loop, while smaller doses appear to affect selectively the more distal portions of the proximal convolution and its medullary portion.2 Subnecrotizing doses may produce no more than swelling of the epithelium, presumably, in the more distal segments of the proximal nephron. Recently Oliver and associates3 have drawn attention to a second type of tubular lesion which may be found in cases of poisoning with corrosive mercuric chloride and which is indistinguishable from that found in shock-like states such as following crushing injuries and transfusion of incompatible blood. The second type of lesion differs from the nephrotoxic lesion found uniformly in the proximal nephron; it consists of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

FUNCTION RECOVERY PATTERN IN ACUTE RENAL FAILURE FOLLOWING INGESTION OF MERCURIC CHLORIDE

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Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1953.02050070650001
Publisher site
See Article on Publisher Site

Abstract

THE CHARACTERISTIC renal lesion produced by mercuric chloride has been described as being confined largely to the proximal tubule.1 Large doses of mercury tend to produce necrosis extending the whole length of the proximal tubule from the glomerulus to the descending loop, while smaller doses appear to affect selectively the more distal portions of the proximal convolution and its medullary portion.2 Subnecrotizing doses may produce no more than swelling of the epithelium, presumably, in the more distal segments of the proximal nephron. Recently Oliver and associates3 have drawn attention to a second type of tubular lesion which may be found in cases of poisoning with corrosive mercuric chloride and which is indistinguishable from that found in shock-like states such as following crushing injuries and transfusion of incompatible blood. The second type of lesion differs from the nephrotoxic lesion found uniformly in the proximal nephron; it consists of

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Jun 1, 1953

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