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Frontotemporal Dementia in Elderly Individuals

Frontotemporal Dementia in Elderly Individuals ORIGINAL CONTRIBUTION Atik Baborie, MD; Tim D. Griffiths, DM; Evelyn Jaros, PhD; Parastoo Momeni, PhD; Ian G. McKeith, MD; David J. Burn, MD; G. Keir, PhD; Andrew J. Larner, MD; David M. Mann, PhD; Robert Perry, MD Objective: To determine whether cases of frontotem- tia with TDP-43, a composition similar to presenile- poral lobar degeneration (FTLD) do exist in elderly in- onset FTLD. However, hippocampal sclerosis was more dividuals and have clinical and neuropathological fea- common in elderly patients with FTLD than patients with tures distinct from those with presenile onset. presenile-onset FTLD (82% vs 37%) and more severe in elderly patients with FTLD (P .05). By contrast, se- Design: Retrospective matched cohort study. vere atrophy of the frontal and temporal lobes was less common in elderly patients with FTLD (frontal: 45%; tem- Setting: Regional Neuroscience Centre, North East En- poral: 27%) than patients with presenile-onset FTLD gland. (frontal: 63%; temporal: 78%). Elderly patients with FTLD represented 3.2% of all elderly patients with dementia au- Patients: We compared clinicopathological features of topsied at Newcastle General Hospital. 11 cases of FTLD in elderly individuals with 19 cases of presenile-onset FTLD. Conclusions: Frontotemporal lobar degeneration in el- derly patients does exist http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2011.3323
pmid
22529248
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Atik Baborie, MD; Tim D. Griffiths, DM; Evelyn Jaros, PhD; Parastoo Momeni, PhD; Ian G. McKeith, MD; David J. Burn, MD; G. Keir, PhD; Andrew J. Larner, MD; David M. Mann, PhD; Robert Perry, MD Objective: To determine whether cases of frontotem- tia with TDP-43, a composition similar to presenile- poral lobar degeneration (FTLD) do exist in elderly in- onset FTLD. However, hippocampal sclerosis was more dividuals and have clinical and neuropathological fea- common in elderly patients with FTLD than patients with tures distinct from those with presenile onset. presenile-onset FTLD (82% vs 37%) and more severe in elderly patients with FTLD (P .05). By contrast, se- Design: Retrospective matched cohort study. vere atrophy of the frontal and temporal lobes was less common in elderly patients with FTLD (frontal: 45%; tem- Setting: Regional Neuroscience Centre, North East En- poral: 27%) than patients with presenile-onset FTLD gland. (frontal: 63%; temporal: 78%). Elderly patients with FTLD represented 3.2% of all elderly patients with dementia au- Patients: We compared clinicopathological features of topsied at Newcastle General Hospital. 11 cases of FTLD in elderly individuals with 19 cases of presenile-onset FTLD. Conclusions: Frontotemporal lobar degeneration in el- derly patients does exist

Journal

JAMA NeurologyAmerican Medical Association

Published: Aug 1, 2012

References