Abstract One of the most common problems brought to the attention of today's pediatrician is the question of a possible association between ingestion of a particular food and symptoms experienced by a child. Publications to which parents have ready access, including newspapers, are replete with reports of various adverse reactions to foods in children (commonly called "allergy"). Because the pediatrician is considered by parents to be an authority on health matters, he is often requested to comment on reports that parents have read. This is a difficult task because often the reports are based on comments made at meetings that are not available in print for the pediatrician to analyze critically. Even if there is a written report, it may be difficult for the pediatrician to spend the time required to help parents become critical readers of lay publications. This review considers the topic of food sensitivity, including the basic principles References 1. May CD, Bock SA: A modern clinical approach to food hypersensitivity . Allergy 33:166-188, 1978.Crossref 2. May CD: Food hypersensitivity , in Gupta S, Good RD (eds): Cellular, Molecular, and Clinical Aspects of Allergic Disorders . New York, Plenum Press Inc, 1979, pp 321-354. 3. Rieger CHL, Rothberg RM: Development of the capacity to produce specific antibody to an ingested food antigen in the premature infant . J Pediatr 87:515-518, 1975.Crossref 4. May CD, Remigio LK, Feldman J, et al: A study of serum antibodies to isolated milk proteins and ovalbumin in infants and children . Clin Allergy 7:583-595, 1977.Crossref 5. May CD, Remigio LK, Bock SA: Usefulness of measurement of antibodies in serum in diagnosis of sensitivity to cow-milk and soy proteins in early childhood . Allergy , to be published. 6. Walker WA, Isselbacher KJ: Uptake and transport of macromolecules by the intestine: Possible role in clinical disorders . Gastroenterology 67:531-550, 1974. 7. Abrahamson DR, Powers A, Rodewald R: Intestinal absorption of immune complexes by neonatal rats: A route of antigen transfer from mother to young . Science 206:567-569, 1979.Crossref 8. Selbekk BH, Aas K, Myren J: In vitro sensitization and mast cell degranulation in human jejunal mucosa . Scand J Gastroenterol 13:87-92, 1978.Crossref 9. Owen RL: Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: An ultrastructural study . Gastroenterology 72:440-451, 1977. 10. Rodricks JV: Food hazards of natural origin . Fed Proc 37:2587-2593, 1978. 11. Bock SA, Buckley J, Holst A, et al: Proper use of skin tests with food extracts in diagnosis of hypersensitivity to food in children . Clin Allergy 7:375-383, 1977.Crossref 12. Bock SA, Lee W-Y, Remigio L, et al: Appraisal of skin tests with food extracts for diagnosis of food hypersensitivity . Clin Allergy 8:559-564, 1978.Crossref 13. Parrish WE: Detection of reaginic and short-term sensitizing anaphylactic or anaphylactoid antibodies to milk in sera of allergic and normal persons . Clin Allergy 1:369-380, 1971.Crossref 14. Bryant DH, Burns MW, Lazarus L: Identification of IgG antibody as a carrier of reaginic activity in asthmatic patients . J Allergy Clin Immunol 56:417-428, 1975.Crossref 15. Bock SA, Lee W-Y, Remigio L, et al: Studies of hypersensitivity reactions to foods in infants and children . J Allergy Clin Immunol 62:327-334, 1978.Crossref 16. Strober W, Falchuk ZM, Rogentine GN, et al: The pathogenesis of gluten-sensitive enteropathy . Ann Intern Med 83:242-256, 1975.Crossref 17. Falchuk ZM, Gebbard RL, Sessoms C, et al: An in vitro model of gluten-sensitive enteropathy: Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture . J Clin Invest 53:487-508, 1974.Crossref 18. Falchuk ZM, Strober W: Gluten-sensitive enteropathy: Synthesis of antigliaden antibody in vitro . Gut 15:947-952, 1974.Crossref 19. Katz AJ, Falchuk ZM: Definitive diagnosis of gluten-sensitive enteropathy: Use of an in vitro organ culture model . Gastroenterology 75:695-700, 1978. 20. Falchuk ZM, Katz AJ, Shwachman H, et al: Gluten-sensitive enteropathy: Genetic analysis and organ culture study in 35 families . Scand J Gastroenterol 13:839-843, 1978.Crossref 21. Keuning JJ, Pena AS, van Hooff JP, et al: HLA-Dw3 associated with coeliac disease . Lancet 1:506-508, 1976.Crossref 22. Lloyd-Still JD, Shwachman H, Filler RM: Protracted diarrhea of infancy treated by intravenous alimentation: I. Clinical studies of 16 infants . Am J Dis Child 125:358-364, 1973. 23. Shwachman H, Lloyd-Still JD, Khaw K-T, et al: Protracted diarrhea of infancy treated by intravenous alimentation: II. Studies of small intestinal biopsy results . Am J Dis Child 125:365-368, 1973. 24. Savilahti E: Immunochemical study of the malabsorption syndrome with cow's milk intolerance . Gut 14:491-501, 1973.Crossref 25. Kuitunen P, Rapola J, Savilahti E, et al: Response of the jejunal mucosa to cow's milk in the malabsorption syndrome with cow's milk intolerance . Acta Paediatr Scand 62:585-595, 1973.Crossref 26. Shiner M, Ballard J, Brook CGD, et al: Intestinal biopsy in the diagnosis of cow's milk protein intolerance without acute symptoms . Lancet 2:1060-1063, 1975.Crossref 27. Walker-Smith J, Harrison M, Kilby A, et al: Cow's milk-sensitive enteropathy . Arch Dis Child 53:375-380, 1978.Crossref 28. Ament ME, Rubin CE: Soy protein: Another cause of the flat intestinal lesion . Gastroenterology 62:227-234, 1972. 29. Mendoza J, Meyers J: Soybean sensitivity: Case report . Pediatrics 46:774-775, 1970. 30. Mortimer CZ: Anaphylaxis following ingestion of soybean . J Pediatr 58:90-92, 1961.Crossref 31. Whitington PF, Gibson R: Soy protein intolerance: Four patients with concomitant cow's milk intolerance . Pediatrics 59:730-732, 1977. 32. Eastham EJ, Lichanco T, Grady MI, et al: Antigenicity of infant formulas: Role of immature intestine on protein permeability . J Pediatr 93:561-564, 1978.Crossref 33. Waldman TA, Wochner RD, Laster L, et al: Allergic gastroenteropathy: A cause of excessive gastrointestinal protein loss . N Engl J Med 276:761-769, 1967.Crossref 34. Wilson JF, Heiner DC, Lahey ME: Evidence of gastrointestinal dysfunction in infants with iron deficiency anemia: A preliminary report . J Pediatr 60:787-800, 1962.Crossref 35. Wilson JF, Lahey ME, Heiner DC: Further observations on cow's milk-induced gastrointestinal bleeding in infants with iron deficiency anemia . J Pediatr 84:335-344, 1974.Crossref 36. Katz AJ, Goldman H, Grand R: Gastric mucosal biopsy in eosinophilic (allergic) gastroenteritis . Gastroenterology 73:705-709, 1977. 37. Heiner DC, Sears JW, Kniker WT: Multiple precipitins to cow's milk in chronic respiratory disease . Am J Dis Child 103:634-654, 1962. 38. Holland NH, Hong R, Davis NC, et al: Significance of precipitating antibodies to milk proteins in the serum of infants and children . J Pediatr 61:181-195, 1962.Crossref 39. Lee SK, Kniker WT, Cook CD, et al: Cow's milk-induced pulmonary disease in children . Acta Paediatr Scand 25:39-57, 1978. 40. Anderson JA, Weiss L, Rebuck SW, et al: Hyperreactivity to cow's milk in an infant with LE and tart cell phenomenon . J Pediatr 84:59-67, 1974.Crossref 41. Boat TF, Polmar SH, Whitman V, et al: Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction . J Pediatr 87:23-29, 1975.Crossref 42. Aas K: The diagnosis of hypersensitivity to ingested foods: Reliability of skin prick testing and radioallergosorbent test with different materials . Clin Allergy 8:39-50, 1978.Crossref 43. Rothberg RM, Farr RS: Antibovine serum albumin and antialpha lactalbumin in the serum of children and adults . Pediatrics 35:571-588, 1965. 44. Gunther M, Cheek E, Matthews RH, et al: Immune responses in infants to cow's milk proteins taken by mouth . Int Arch Allergy Appl Immunol 21:257-278, 1962.Crossref 45. Kletter B, Gery I, Freier S, et al: Immune responses of normal infants to cow milk: I. Antibody type and kinetics of production . Int Arch Allergy Appl Immunol 40:656-666, 1971.Crossref 46. Gryboski JD: Gastrointestinal milk allergy in infants . Pediatrics 40:354-362, 1967. 47. Matthews TS, Soothill JF: Complement activation after milk feeding in children with cow's milk allergy . Lancet 2:893-895, 1970.Crossref 48. Spitzer RE, Stitzel AE, Urmson JR, et al: Utilization of properdin in children with vasculitis and milk allergy, abstracted . Pediatr Res 12:487, 1978. 49. Strunk RC, Pinnas JL, John TJ, et al: Rice hypersensitivity associated with serum complement depression . Clin Allergy 8:51-58, 1978.Crossref 50. Sandberg DH, Bernstein CW, McIntosh RM, et al: Severe steroid-responsive nephrosis associated with hypersensitivity . Lancet 1:388-391, 1977.Crossref 51. Bock SA, Remigio LK, May CD, et al: Detection of specific immunoglobulins and cow-milk proteins in small bowel biospies, abstracted . Pediatr Res 13:723, 1979. 52. Hekkens WTJM, Pena AS (eds): Coeliac Disease: Proceedings of the Second International Coeliac Symposium. Leiden, the Netherlands, HE Stenfert Kroese, 1974. 53. May CD, Alberto R: In vivo stimulation of peripheral lymphocytes to proliferation after oral challenge of children allergic to foods . Int Arch Allergy Appl Immunol 43:525-532, 1972.Crossref 54. Dannaeus A, Foucard T, Johansson SG: The effect of orally administered sodium cromoglycate on symptoms of food allergy . Clin Allergy 7:109-115, 1977.Crossref 55. Pittard WB III: Breast milk immunology: A frontier in infant nutrition . Am J Dis Child 133:83-87, 1979. 56. Welsh JK, May JT: Anti-infective properties of breast milk . J Pediatr 94:1-9, 1979.Crossref 57. Saarinen UM, Backman A, Kajosaari M, et al: Prolonged breast-feeding as prophylaxis for atopic disease . Lancet 2:163-166, 1979.Crossref 58. Harris MJ, Petts V, Penny R: Cow's milk allergy as a cause of infantile colic: Immunofluorescent studies on jejunal mucosa . Aust Paediatr J 13:276-281, 1977. 59. Dannaeus A, Johansson SG, Foucard T: Clinical and immunological aspects of food allergy in childhood: II. Development of allergic symptoms and humoral immune response to foods in infants of atopic mothers during the first 24 months of life . Acta Paediatr Scand 67:497-504, 1978.Crossref 60. Orgel HA, Hamburger RN, Bazaral M, et al: Development of IgE and allergy in infancy . J Allergy Clin Immunol 56:296-307, 1975.Crossref 61. Kjellman NI, Johansson SG: IgE and atopic allergy in newborns and infants with a family history of atopic disease . Acta Paediatr Scand 65:601-607, 1976.Crossref 62. Harley JP, Ray RS, Tomasi L, et al: Hyperkinesis and food additives: Testing the Feingold hypothesis . Pediatrics 61:818-828, 1978. 63. Harley JP, Matthews CG, Eichman P: Synthetic food colors and hyperactivity in children: A double-blind challenge experiment . Pediatrics 62:975-983, 1978. 64. May CD, Bock SA: Adverse reactions to food due to hypersensitivity , in Middleton E, Reed C, Ellis E (eds): Allergy: Principles and Practice . St Louis, CV Mosby Co, 1978, chap 62. 65. Golbert TM: A review of controversial diagnostic and therapeutic techniques employed in allergy . J Allergy Clin Immunol 56:170-190, 1975.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Oct 1, 1980
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera