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Flurbiprofen Pretreatment in Argon Laser Trabeculoplasty for Primary Open-Angle Glaucoma

Flurbiprofen Pretreatment in Argon Laser Trabeculoplasty for Primary Open-Angle Glaucoma Abstract • We examined the influence of topically administered flurbiprofen sodium 0.03%, a potent prostaglandin inhibitor, on the inflammatory response and intraocular pressure following argon laser trabeculoplasty. Our investigation included one eye of each of 118 patients with primary open-angle glaucoma in whom laser trabeculoplasty was indicated. Sixty-three patients received flurbiprofen and 55 received a vehicle during the two-hour period immediately preceding laser therapy and for one week postoperatively. No significant differences in postoperative IOPs were noted between groups. However, when we considered conjunctival erythema at 24 hours or control of inflammation at the termination of the investigation, the eyes receiving flurbiprofen had less inflammation than did the vehicle-treated eyes. References 1. Thomas JV, Simmons RJ, Belcher CD: Complications of argon laser trabeculoplasty . Glaucoma 1982;4:50-52. 2. Forbes M, Balsal RK: Argon laser goniophotocoagulation of the trabecular meshwork in open angle glaucoma . Trans Am Ophthalmol Soc 1981;79:257-272. 3. Wilensky JT, Weinreb RN: Early and late failures of argon laser trabeculoplasty . Arch Ophthalmol 1983;101:895-897.Crossref 4. Thomas JV, Simmons RJ, Belcher CD: Argon laser trabeculoplasty in the presurgical glaucoma patient . Ophthalmology 1982;89:187-197.Crossref 5. Weinreb RN, Ruderman J, Juster R, et al: Immediate intraocular pressure response to argon laser trabeculoplasty . Am J Ophthalmol 1983;95:279-286. 6. Schwartz LW, Spaeth GL, Traverso C, et al: Variation of techniques on the results of argon laser trabeculoplasty . Ophthalmology 1983; 90:781-784.Crossref 7. Weinreb RN, Wilensky JT: Clinical aspects of laser trabeculoplasty . Int Ophthalmol Clin 1984;24:79-96. 8. Weinreb RN, Ruderman J, Juster R, et al: Influence of the number of laser burns administered on the early results of argon laser trabeculoplasty . Am J Ophthalmol 1983;95:287-292. 9. Ruderman JN, Zweig KO, Wilensky JT, et al: Effects of corticosteroid pretreatment on argon laser trabeculoplasty . Am J Ophthalmol 1983;96:84-89. 10. Kimura S, Thygeson P, Hogan MJ: Signs and symptoms of uveitis: I. Anterior uveitis . Am J Ophthalmol 1959;47:155-170. 11. Eakins KE: Prostaglandin and non-prostaglandin mediated breakdown of the blood-aqueous barrier in the ocular and cerebrospinal fluids , in Bito LZ, Davson H, Fenstermacho J (eds): Fogarty International Symposium . New York, Academic Press Inc, 1977, pp 483-493. 12. Unger WG, Cole DF, Bass MD: Prostaglandins and neurologically-mediated ocular response to laser irradiation of the rabbit iris . Exp Eye Res 1977;25:209-220.Crossref 13. Sanders DR, Joondeph B, Hutchins R, et al: Studies on the blood-aqueous barrier after argon laser photocoagulation of the iris . Ophthalmology 1982;100:588-590. 14. Eakins KE: Increased intraocular pressure produced by prostaglandin El and E2 in the cat eye . Exp Eye Res 1970;10:87-92.Crossref 15. Weinreb RN, Drake MV: Treatment parameters of laser trabeculoplasty . Trans Pac Coast Otoophthalmol Soc 1984;64:75-80. 16. Hotchkiss ML, Robin AL, Pollack IP, et al: Nonsteroidal anti-inflammatory agents after argon laser trabeculoplasty: A trial with flurbiprofen and indomethacin. Ophthalmology, in press. 17. Feller DB, Weinreb RN: Breakdown and reestablishment of blood-aqueous barrier with laser trabeculoplasty . Arch Ophthalmol 1984; 102:537-538.Crossref 18. Bhatacherjee P, Eakins KE: Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin . Br J Pharmacol 1974; 50:227-230.Crossref 19. Higgs GA, Eakins KE, Mugridge KG, et al: The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carageenin-induced inflammation . Eur J Pharmacol 1980; 66:81-86.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Flurbiprofen Pretreatment in Argon Laser Trabeculoplasty for Primary Open-Angle Glaucoma

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040031319016
Publisher site
See Article on Publisher Site

Abstract

Abstract • We examined the influence of topically administered flurbiprofen sodium 0.03%, a potent prostaglandin inhibitor, on the inflammatory response and intraocular pressure following argon laser trabeculoplasty. Our investigation included one eye of each of 118 patients with primary open-angle glaucoma in whom laser trabeculoplasty was indicated. Sixty-three patients received flurbiprofen and 55 received a vehicle during the two-hour period immediately preceding laser therapy and for one week postoperatively. No significant differences in postoperative IOPs were noted between groups. However, when we considered conjunctival erythema at 24 hours or control of inflammation at the termination of the investigation, the eyes receiving flurbiprofen had less inflammation than did the vehicle-treated eyes. References 1. Thomas JV, Simmons RJ, Belcher CD: Complications of argon laser trabeculoplasty . Glaucoma 1982;4:50-52. 2. Forbes M, Balsal RK: Argon laser goniophotocoagulation of the trabecular meshwork in open angle glaucoma . Trans Am Ophthalmol Soc 1981;79:257-272. 3. Wilensky JT, Weinreb RN: Early and late failures of argon laser trabeculoplasty . Arch Ophthalmol 1983;101:895-897.Crossref 4. Thomas JV, Simmons RJ, Belcher CD: Argon laser trabeculoplasty in the presurgical glaucoma patient . Ophthalmology 1982;89:187-197.Crossref 5. Weinreb RN, Ruderman J, Juster R, et al: Immediate intraocular pressure response to argon laser trabeculoplasty . Am J Ophthalmol 1983;95:279-286. 6. Schwartz LW, Spaeth GL, Traverso C, et al: Variation of techniques on the results of argon laser trabeculoplasty . Ophthalmology 1983; 90:781-784.Crossref 7. Weinreb RN, Wilensky JT: Clinical aspects of laser trabeculoplasty . Int Ophthalmol Clin 1984;24:79-96. 8. Weinreb RN, Ruderman J, Juster R, et al: Influence of the number of laser burns administered on the early results of argon laser trabeculoplasty . Am J Ophthalmol 1983;95:287-292. 9. Ruderman JN, Zweig KO, Wilensky JT, et al: Effects of corticosteroid pretreatment on argon laser trabeculoplasty . Am J Ophthalmol 1983;96:84-89. 10. Kimura S, Thygeson P, Hogan MJ: Signs and symptoms of uveitis: I. Anterior uveitis . Am J Ophthalmol 1959;47:155-170. 11. Eakins KE: Prostaglandin and non-prostaglandin mediated breakdown of the blood-aqueous barrier in the ocular and cerebrospinal fluids , in Bito LZ, Davson H, Fenstermacho J (eds): Fogarty International Symposium . New York, Academic Press Inc, 1977, pp 483-493. 12. Unger WG, Cole DF, Bass MD: Prostaglandins and neurologically-mediated ocular response to laser irradiation of the rabbit iris . Exp Eye Res 1977;25:209-220.Crossref 13. Sanders DR, Joondeph B, Hutchins R, et al: Studies on the blood-aqueous barrier after argon laser photocoagulation of the iris . Ophthalmology 1982;100:588-590. 14. Eakins KE: Increased intraocular pressure produced by prostaglandin El and E2 in the cat eye . Exp Eye Res 1970;10:87-92.Crossref 15. Weinreb RN, Drake MV: Treatment parameters of laser trabeculoplasty . Trans Pac Coast Otoophthalmol Soc 1984;64:75-80. 16. Hotchkiss ML, Robin AL, Pollack IP, et al: Nonsteroidal anti-inflammatory agents after argon laser trabeculoplasty: A trial with flurbiprofen and indomethacin. Ophthalmology, in press. 17. Feller DB, Weinreb RN: Breakdown and reestablishment of blood-aqueous barrier with laser trabeculoplasty . Arch Ophthalmol 1984; 102:537-538.Crossref 18. Bhatacherjee P, Eakins KE: Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin . Br J Pharmacol 1974; 50:227-230.Crossref 19. Higgs GA, Eakins KE, Mugridge KG, et al: The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carageenin-induced inflammation . Eur J Pharmacol 1980; 66:81-86.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1984

References