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Fluoroquinolone Resistance in Neisseria gonorrhoeae--Colorado and Washington, 1995

Fluoroquinolone Resistance in Neisseria gonorrhoeae--Colorado and Washington, 1995 Abstract THE FLUOROQUINOLONES ciprofloxacin and ofloxacin are among the antimicrobial agents recommended by CDC for treating gonorrhea.1 In the United States, decreased susceptibility or resistance of strains of Neisseria gonorrhoeae to the fluoroquinolones has been reported only sporadically, and treatment failure associated within vitro resistance has not been described.2 However, the recent occurrence of resistant cases in Denver and Seattle suggests that clinically important resistance to the fluoroquinolones may be emerging. This report describes the findings of the investigations of these cases. On May 24, 1995, a 35-year-old man presented to the Denver Public Health Sexually Transmitted Diseases Clinic with a history of dysuria and urethral discharge of approximately 1 month's duration. On March 11, he had returned from a ''dating tour'' of the Philippines during which he had had sexual contact with seven or eight female sex workers (ie, prostitutes); he denied sexual contact since returning to the References 1. CDC. 1993 Sexually transmitted diseases treatment guidelines . MMWR 1993;42(no. (RR-14) ): 4-5. 2. CDC. Decreased susceptibility of Neisseria gonorrhoeae to fluoroquinolones--Ohio and Hawaii, 1992-1993 . MMWR 1994;43:325-7. 3. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests: approved standard . 5th ed. Villanova, Pennsylvania: National Committee for Clinical Laboratory Standards, 1993: NCCLS document no. M2-A5. (Vol 13, no. (24) ). 4. Sarafian SK, Knapp JS. Molecular epidemiology of gonorrhea . Clin Micro Rev 1989;2( (suppl) ):S49-S55. 5. Knapp JS, Hale JA, Neal SW, Wintersheid K, Whittington WL. Proposed criteria for the interpretation of susceptibilities of strains of Neisseria gonorrhoeae to ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, and norfloxacin . Antimicrob Agents Chemother 1995;39 (in press). 6. Tapsall JW, Lovett R, Munro R. Failure of 500 mg ciprofloxacin therapy in male urethral gonorrhea . Med J Aust 1992;156:143. 7. Birley H, MacDonald P, Carey P, Fletcher J. High-level ciprofloxacin resistance in Neisseria gonorrhoeae . Genitourin Med 1994;70:292-3. 8. Kam KM, Lo KK, Ng KYH, Cheung MM. Rapid decline in penicillinase-producing Neisseria gonorrhoeae in Hong Kong associated with emerging 4-fluoroquinolone resistance . Genitourin Med 1995;71:141-4. 9. Manalastas R, Abellanosa IP, Melosa VP, et al. Fluoroquinolone resistance in Neisseria gonorrhoeae in the Republic of the Philippines [Abstract] . In: Proceedings of the IUVDT World STD/AIDS Congress 1995 . Singapore: International Union Against the Venereal Diseases and the Treponematoses, 1995:136. 10. Schwarcz SK, Zenilman JM, Schnell D, et al. National surveillance of antimicrobial resistance in Neisseria gonorrhoeae . JAMA 1990;264:1413-7.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Fluoroquinolone Resistance in Neisseria gonorrhoeae--Colorado and Washington, 1995

Archives of Dermatology , Volume 131 (12) – Dec 1, 1995

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1995.01690240021003
Publisher site
See Article on Publisher Site

Abstract

Abstract THE FLUOROQUINOLONES ciprofloxacin and ofloxacin are among the antimicrobial agents recommended by CDC for treating gonorrhea.1 In the United States, decreased susceptibility or resistance of strains of Neisseria gonorrhoeae to the fluoroquinolones has been reported only sporadically, and treatment failure associated within vitro resistance has not been described.2 However, the recent occurrence of resistant cases in Denver and Seattle suggests that clinically important resistance to the fluoroquinolones may be emerging. This report describes the findings of the investigations of these cases. On May 24, 1995, a 35-year-old man presented to the Denver Public Health Sexually Transmitted Diseases Clinic with a history of dysuria and urethral discharge of approximately 1 month's duration. On March 11, he had returned from a ''dating tour'' of the Philippines during which he had had sexual contact with seven or eight female sex workers (ie, prostitutes); he denied sexual contact since returning to the References 1. CDC. 1993 Sexually transmitted diseases treatment guidelines . MMWR 1993;42(no. (RR-14) ): 4-5. 2. CDC. Decreased susceptibility of Neisseria gonorrhoeae to fluoroquinolones--Ohio and Hawaii, 1992-1993 . MMWR 1994;43:325-7. 3. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests: approved standard . 5th ed. Villanova, Pennsylvania: National Committee for Clinical Laboratory Standards, 1993: NCCLS document no. M2-A5. (Vol 13, no. (24) ). 4. Sarafian SK, Knapp JS. Molecular epidemiology of gonorrhea . Clin Micro Rev 1989;2( (suppl) ):S49-S55. 5. Knapp JS, Hale JA, Neal SW, Wintersheid K, Whittington WL. Proposed criteria for the interpretation of susceptibilities of strains of Neisseria gonorrhoeae to ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, and norfloxacin . Antimicrob Agents Chemother 1995;39 (in press). 6. Tapsall JW, Lovett R, Munro R. Failure of 500 mg ciprofloxacin therapy in male urethral gonorrhea . Med J Aust 1992;156:143. 7. Birley H, MacDonald P, Carey P, Fletcher J. High-level ciprofloxacin resistance in Neisseria gonorrhoeae . Genitourin Med 1994;70:292-3. 8. Kam KM, Lo KK, Ng KYH, Cheung MM. Rapid decline in penicillinase-producing Neisseria gonorrhoeae in Hong Kong associated with emerging 4-fluoroquinolone resistance . Genitourin Med 1995;71:141-4. 9. Manalastas R, Abellanosa IP, Melosa VP, et al. Fluoroquinolone resistance in Neisseria gonorrhoeae in the Republic of the Philippines [Abstract] . In: Proceedings of the IUVDT World STD/AIDS Congress 1995 . Singapore: International Union Against the Venereal Diseases and the Treponematoses, 1995:136. 10. Schwarcz SK, Zenilman JM, Schnell D, et al. National surveillance of antimicrobial resistance in Neisseria gonorrhoeae . JAMA 1990;264:1413-7.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1995

References