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FLUORIDE IN OTOSCLEROSIS-Reply

FLUORIDE IN OTOSCLEROSIS-Reply This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor: We are presently carrying out studies on the action of various doses of sodium fluoride on bone calcification in newborn and young rats, the first results of which will be published in the near future. Our findings can be summarized in the following way: When given in daily doses of a certain range, sodium fluoride has definitely a promoting effect on the amount of calcium deposits resulting both from a depressing action on bone resorption and from a favoring action on bone calcification. When sodium fluoride daily doses exceeded a certain amount, an opposite, rather deleterious, effect on bone calcification was observed. But we must emphasize that this harmful dose was almost 100 times the strength of the smallest amount inducing a promoting effect. We are dealing here with young rats and not humans; therefore, we cannot simply transpose these observations from animal experiments to clinical treatment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

FLUORIDE IN OTOSCLEROSIS-Reply

Archives of Otolaryngology , Volume 82 (5) – Nov 1, 1965

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1965.00760010553022
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor: We are presently carrying out studies on the action of various doses of sodium fluoride on bone calcification in newborn and young rats, the first results of which will be published in the near future. Our findings can be summarized in the following way: When given in daily doses of a certain range, sodium fluoride has definitely a promoting effect on the amount of calcium deposits resulting both from a depressing action on bone resorption and from a favoring action on bone calcification. When sodium fluoride daily doses exceeded a certain amount, an opposite, rather deleterious, effect on bone calcification was observed. But we must emphasize that this harmful dose was almost 100 times the strength of the smallest amount inducing a promoting effect. We are dealing here with young rats and not humans; therefore, we cannot simply transpose these observations from animal experiments to clinical treatment.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Nov 1, 1965

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