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Flucytosine-Miconazole Treatment of Candida Peritonitis: Its Use During Continuous Ambulatory Peritoneal Dialysis

Flucytosine-Miconazole Treatment of Candida Peritonitis: Its Use During Continuous Ambulatory... Abstract • A case of Candida parapsilosis peritonitis occurred in a patient undergoing continuous ambulatory peritoneal dialysis (CAPD). Treatment with oral doses of flucytosine and intravenous doses of miconazole was effective. No interruption in CAPD was necessary, and acceptable flucytosine levels were obtained in the serum and dialysate. This case and information available in the literature suggest that Candida peritonitis can be treated effectively with antimicrobial agents that are well tolerated by the patient, and removal of the dialysis catheter is not always necessary for cure. (Arch Intern Med 1982;142:577-578) References 1. Rubin J, Rogers WA, Taylor HM, et al: Peritonitis during continuous ambulatory peritoneal dialysis. Ann Intern Med 1980;92:7-13.Crossref 2. Arfania D, Everett D, Nolph KD, et al: Uncommon causes of peritonitis in patients undergoing peritoneal dialysis. Arch Intern Med 1981;141:61-64.Crossref 3. Khanna R, Oreopoulos DG, Vas S, et al: Fungal peritonitis in patients undergoing chronic intermittent or continuous ambulatory peritoneal dialysis. Proc Eur Dial Transplant Assoc 1980;17:291-296. 4. Andersen KEM, Olsen H: Candida peritonitis in a patient receiving chronic intermittent peritoneal dialysis. Scand J Infect Dis 1978;10:91-92. 5. Holdsworth SR, Atkins RC, Jackson R: Management of Candida peritonitis by prolonged peritoneal lavage containing 5-fluorocytosine. Clin Nephrol 1975;4:157-159. 6. Drouhet E, Babinet P, Chapusot JP, et al: 5-Fluorocytosine in the treatment of candidiasis with acute renal insufficiency: Its kinetics during hemodialysis and peritoneal dialysis. Biomedicine 1973;19:408-414. 7. Wise GJ, Kozinn PJ, Goldberg P: Flucytosine in the management of genitourinary candidiasis: Five years of experience. J Urol 1980;124:70-72. 8. Schonebeck J, Ansehn S: 5-Fluorocytosine resistance in Candida species and Torulopsis glabrata. Sabouraudia 1973;11:10-20.Crossref 9. Shadomy S, Espinel-Ingroff A: Susceptibility testing with antifungal drugs , in Lennette EH, Balows A, Hausler WJ, et al (eds): Manual of Clinical Microbiology , ed 3. Washington, DC, American Society for Microbiology, 1980, pp 647-653. 10. Odds FC: Laboratory evaluation of antifungal agents: A comparative study of five imidazole derivatives of clinical importance. J Antimicrob Chemother 1980;6:749-761.Crossref 11. Medoff G, Kobayashi GS: Strategies in the treatment of systemic fungal infections. N Engl J Med 1980;302:145-155.Crossref 12. Graybill JR, Drutz DJ: Ketoconazole: A major innovation for treatment of fungal disease. Ann Intern Med 1980;93:921-923.Crossref 13. Van Cutsem JM, Thienpoint D: Miconazole: A broad-spectrum antimycotic agent with antibacterial activity. Chemotherapy 1972;17:392-404.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Flucytosine-Miconazole Treatment of Candida Peritonitis: Its Use During Continuous Ambulatory Peritoneal Dialysis

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340160157028
Publisher site
See Article on Publisher Site

Abstract

Abstract • A case of Candida parapsilosis peritonitis occurred in a patient undergoing continuous ambulatory peritoneal dialysis (CAPD). Treatment with oral doses of flucytosine and intravenous doses of miconazole was effective. No interruption in CAPD was necessary, and acceptable flucytosine levels were obtained in the serum and dialysate. This case and information available in the literature suggest that Candida peritonitis can be treated effectively with antimicrobial agents that are well tolerated by the patient, and removal of the dialysis catheter is not always necessary for cure. (Arch Intern Med 1982;142:577-578) References 1. Rubin J, Rogers WA, Taylor HM, et al: Peritonitis during continuous ambulatory peritoneal dialysis. Ann Intern Med 1980;92:7-13.Crossref 2. Arfania D, Everett D, Nolph KD, et al: Uncommon causes of peritonitis in patients undergoing peritoneal dialysis. Arch Intern Med 1981;141:61-64.Crossref 3. Khanna R, Oreopoulos DG, Vas S, et al: Fungal peritonitis in patients undergoing chronic intermittent or continuous ambulatory peritoneal dialysis. Proc Eur Dial Transplant Assoc 1980;17:291-296. 4. Andersen KEM, Olsen H: Candida peritonitis in a patient receiving chronic intermittent peritoneal dialysis. Scand J Infect Dis 1978;10:91-92. 5. Holdsworth SR, Atkins RC, Jackson R: Management of Candida peritonitis by prolonged peritoneal lavage containing 5-fluorocytosine. Clin Nephrol 1975;4:157-159. 6. Drouhet E, Babinet P, Chapusot JP, et al: 5-Fluorocytosine in the treatment of candidiasis with acute renal insufficiency: Its kinetics during hemodialysis and peritoneal dialysis. Biomedicine 1973;19:408-414. 7. Wise GJ, Kozinn PJ, Goldberg P: Flucytosine in the management of genitourinary candidiasis: Five years of experience. J Urol 1980;124:70-72. 8. Schonebeck J, Ansehn S: 5-Fluorocytosine resistance in Candida species and Torulopsis glabrata. Sabouraudia 1973;11:10-20.Crossref 9. Shadomy S, Espinel-Ingroff A: Susceptibility testing with antifungal drugs , in Lennette EH, Balows A, Hausler WJ, et al (eds): Manual of Clinical Microbiology , ed 3. Washington, DC, American Society for Microbiology, 1980, pp 647-653. 10. Odds FC: Laboratory evaluation of antifungal agents: A comparative study of five imidazole derivatives of clinical importance. J Antimicrob Chemother 1980;6:749-761.Crossref 11. Medoff G, Kobayashi GS: Strategies in the treatment of systemic fungal infections. N Engl J Med 1980;302:145-155.Crossref 12. Graybill JR, Drutz DJ: Ketoconazole: A major innovation for treatment of fungal disease. Ann Intern Med 1980;93:921-923.Crossref 13. Van Cutsem JM, Thienpoint D: Miconazole: A broad-spectrum antimycotic agent with antibacterial activity. Chemotherapy 1972;17:392-404.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1982

References